Vitamin E 用于 动脉粥样硬化
C 证据 来自小型研究的证据有限，但存在一些积极信号。Strong mechanistic rationale (LDL oxidation inhibition) but large RCTs (HOPE, GISSI-Prevenzione) show no benefit. Meta-analysis suggests potential harm at >=400 IU/day. AHA does not recommend supplementation.
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C
结论
Strong mechanistic rationale (LDL oxidation inhibition) but large RCTs (HOPE, GISSI-Prevenzione) show no benefit. Meta-analysis suggests potential harm at >=400 IU/day. AHA does not recommend supplementation.
Key Study Findings
Review
Navigating the Effects of Anti-Atherosclerotic Supplements and Acknowledging Associated Bleeding Risks.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: Review of anti-atherosclerotic supplements and bleeding
Other
Extensive Bioactivity of Astaxanthin from Haematococcus pluvialis in Human.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: None
Other
Supplementation with Resveratrol, Piperine and Alpha-Tocopherol Decreases Chronic Inflammation in a Cluster of Older Adults …
Dose: None
vs: Conventional treatment
Outcome: effect of a dietary supplement on chronic inflammation …
效果: None
p < 0.05
研究人群: None
Review
Nutrient intake, nutritional status, and cognitive function with aging.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: Aging adults (nutrition and cognition)
Review
Role of reactive oxygen species and antioxidants in atopic dermatitis.
Dose: None
vs: None
Outcome: Role of oxidative stress in atopic dermatitis
效果: None
None
研究人群: Patients with atopic dermatitis
Review
Astaxanthin: a novel potential treatment for oxidative stress and inflammation in cardiovascular disease.
Dose: None
vs: None
Outcome: Astaxanthin: a novel potential treatment for oxidative stress …
效果: None
None
研究人群: None
Key Statistics
15
研究数量
50000
受试者
↔
Mixed
C
等级
Referenced Papers
International journal of …
2025
1 次引用
Advances in experimental …
2021
13 次引用
Nutrients
2020
16 次引用
Annals of the …
2016
89 次引用
Journal of clinical …
2013
178 次引用
The American journal …
2008
441 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- note:
- High-dose supplementation no longer recommended based on clinical trial evidence
- general:
- 15 mg/day (22.4 IU)
上限： 1,000 mg/day (1,500 IU natural, 1,100 IU synthetic)
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
最佳服用时间： With meals containing fat
Safety & Side Effects
已报告的副作用
- ⚠ Increased bleeding risk at high doses
- ⚠ Possible increased all-cause mortality at >=400 IU/day
- ⚠ Increased heart failure hospitalization risk (HOPE/HOPE-TOO)
- ⚠ Nausea, diarrhea, fatigue at high doses
已知相互作用
- ● Anticoagulants (increased bleeding risk)
- ● Statins and niacin (may blunt HDL-raising effect)
- ● Chemotherapy and radiation (theoretical interference with oxidative mechanisms)
- ● Vitamin K (may antagonize at high doses)
可耐受最高摄入量： 1,000 mg/day (1,500 IU natural, 1,100 IU synthetic)
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Vitamin E help with 动脉粥样硬化?
Based on 15 studies with 50,000 participants, there is limited but promising evidence that Vitamin E may support 动脉粥样硬化 management. Our evidence grade is C (Some Evidence).
How much Vitamin E should I take for 动脉粥样硬化?
Studies have used various dosages. A commonly studied range is High-dose supplementation no longer recommended based on clinical trial evidence. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin E?
Reported side effects may include Increased bleeding risk at high doses, Possible increased all-cause mortality at >=400 IU/day, Increased heart failure hospitalization risk (HOPE/HOPE-TOO), Nausea, diarrhea, fatigue at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin E and 动脉粥样硬化?
We rate the evidence as Grade C (Some Evidence). This rating is based on 15 peer-reviewed studies with 50,000 total participants. The overall direction of effect is mixed.
Related Evidence
References
- [1] Maria-Zinaida Dobre et al.. Int J Mol Sci. 2025. Navigating the Effects of Anti-Atherosclerotic Supplements and Acknowledging Associated Bleeding Risks. doi:10.3390/ijms262010183 PubMed
- [2] Eiji Yamashita. Adv Exp Med Biol. 2021. Extensive Bioactivity of Astaxanthin from Haematococcus pluvialis in Human. doi:10.1007/978-981-15-7360-6_23 PubMed
- [3] Raúl Francisco Pastor et al.. Nutrients. 2020. Supplementation with Resveratrol, Piperine and Alpha-Tocopherol Decreases Chronic Inflammation in a Cluster of Older Adults with Metabolic Syndrome. doi:10.3390/nu12103149 PubMed
- [4] Katherine L Tucker. Ann N Y Acad Sci. 2016. Nutrient intake, nutritional status, and cognitive function with aging. doi:10.1111/nyas.13062 PubMed
- [5] N Sivaranjani et al.. J Clin Diagn Res. 2013. Role of reactive oxygen species and antioxidants in atopic dermatitis. doi:10.7860/JCDR/2013/6635.3732 PubMed
- [6] Fredric J Pashkow et al.. Am J Cardiol. 2008. Astaxanthin: a novel potential treatment for oxidative stress and inflammation in cardiovascular disease. doi:10.1016/j.amjcard.2008.02.010 PubMed
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