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Vitamin E
Vitamin E

vitamin

别名: Alpha-Tocopherol, d-Alpha-Tocopherol, Mixed Tocopherols, Tocotrienols

About

Vitamin E is the primary lipid-soluble antioxidant in LDL particles and cell membranes. Despite strong mechanistic rationale, large RCTs have been disappointing. The HOPE trial (9,541 participants) found no cardiovascular benefit at 400 IU/day, and a 2005 meta-analysis found high-dose vitamin E (>=400 IU/day) was associated with increased all-cause mortality. Current AHA guidelines do not recommend vitamin E supplementation.

How It Works

Primary lipid-soluble antioxidant in LDL particles and cell membranes; inhibits LDL oxidation — a key early step in atherogenesis; modulates inflammatory gene expression via NF-kB inhibition; inhibits platelet adhesion and smooth muscle cell proliferation.

Evidence For Conditions

健康状况 等级 研究数量 受试者
动脉粥样硬化 C 15 50000 查看 →

Side Effects

  • Increased bleeding risk at high doses
  • Possible increased all-cause mortality at >=400 IU/day
  • Increased heart failure hospitalization risk (HOPE/HOPE-TOO)
  • Nausea, diarrhea, fatigue at high doses

Drug & Supplement Interactions

  • Anticoagulants (increased bleeding risk)
  • Statins and niacin (may blunt HDL-raising effect)
  • Chemotherapy and radiation (theoretical interference with oxidative mechanisms)
  • Vitamin K (may antagonize at high doses)

请务必告知您的医疗保健提供者您正在服用的所有补充剂。

Vitamin D Vitamin K2 Niacin (Vitamin B3) Folate (Vitamin B9)

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