HeartCited is an evidence-based platform that evaluates supplements and natural compounds for cardiovascular health. We analyze peer-reviewed clinical research to help consumers understand which ingredients have scientific support for heart and circulatory system health.

How does HeartCited evaluate heart health supplements?

We review randomized controlled trials, systematic reviews, and meta-analyses from peer-reviewed journals. Each ingredient is assessed for its level of evidence regarding cardiovascular outcomes, typical dosages studied, and safety profile, including potential interactions with cardiac medications.

Are the supplements on HeartCited FDA-approved for heart disease?

Dietary supplements are not FDA-approved to treat, cure, or prevent any disease, including heart disease. The FDA regulates supplements differently from prescription drugs. HeartCited presents published research findings to help consumers make informed decisions in consultation with their healthcare providers.

Can I use HeartCited to replace my cardiologist's advice?

No. HeartCited is an educational resource and should not replace professional medical advice, especially for cardiovascular conditions. Heart disease is a leading cause of death globally, and management requires qualified medical supervision. Always consult your healthcare provider before starting supplements, particularly if you take heart medications.

Is HeartCited free to use?

Yes, HeartCited provides free access to evidence-based information about cardiovascular health supplements. Our mission is to make peer-reviewed research accessible to consumers seeking reliable information about heart health support through dietary supplements.

Evidence-Based Supplement Reviews

Every heart claim cited.

We read the cardiovascular studies so you don't have to.

Browse Ingredients

Evidence-based supplement research you can trust. We analyze peer-reviewed clinical studies from PubMed and grade every supplement ingredient on a transparent A–D scale. No sponsored rankings, no manufacturer influence — just science.

Featured Ingredients

Beetroot Extract

other

Concentrated source of dietary inorganic nitrate converted to nitrite by oral commensal bacteria, then further reduced to nitric oxide in …

1 conditions studied

Berberine

herb

Activates AMPK in hepatocytes, adipocytes, and skeletal muscle; upregulates LDL receptor expression by stabilizing LDLR mRNA via PCSK9 inhibition, increasing …

3 conditions studied

Cocoa Flavanols

other

(-)-Epicatechin and related procyanidins activate endothelial nitric oxide synthase (eNOS) via PI3K/Akt signaling; sustained NO production improves flow-mediated dilation; inhibit …

2 conditions studied

Coenzyme Q10 (CoQ10)

coenzyme

Essential cofactor in mitochondrial electron transport chain (Complex I-III) supporting cellular energy production (ATP) in high-demand cardiac tissue; potent lipid-soluble …

3 conditions studied

Curcumin

herb

Potent modulator of vascular inflammation through NF-kB, JAK/STAT, and MAPK pathway inhibition; reduces endothelial expression of adhesion molecules decreasing monocyte …

2 conditions studied

Garlic

herb

Allicin and S-allylcysteine (SAC) in aged garlic extract inhibit HMG-CoA reductase and cholesterol synthesis; enhance hydrogen sulfide (H2S) production promoting …

1 conditions studied

View all ingredients →

Top Conditions

Arterial Stiffness

Universal with aging; 20-30% of adults >60 have PWV >10 m/s

Usually asymptomatic Contributes to isolated systolic hypertension Widened pulse pressure +1

Atherosclerosis

Subclinical atherosclerosis present in >50% of adults over 40

Often asymptomatic until advanced Angina Claudication +1

Cardiac Arrhythmia

Atrial fibrillation: 33.5 million worldwide; PVCs: present in 75% of healthy adults

Palpitations Skipped beats Racing heart +3

Cardiovascular Inflammation

hs-CRP >2 mg/L present in ~25% of US adults

Usually measured by lab markers (hs-CRP, IL-6, TNF-alpha) Associated with accelerated atherosclerosis Plaque instability

Coronary Artery Disease (CAD)

20.5 million US adults; leading cause of death globally (17.9 million deaths/year)

Angina pectoris (chest pain/pressure with exertion) Shortness of breath Fatigue +1

Elevated Homocysteine (Hyperhomocysteinemia)

5-10% of general population; up to 30-40% of elderly

Usually asymptomatic Associated with premature atherosclerosis Thromboembolism

View all conditions →

Recent Evidence Updates

Lycopene for High Blood Pressure (Hypertension)

6 studies

Selenium for Oxidative Stress (Cardiovascular)

3 studies

Olive Leaf Extract for High Blood Pressure (Hypertension)

5 studies

Flaxseed Oil for High Blood Pressure (Hypertension)

11 studies

Curcumin for Cardiovascular Inflammation

12 studies

Guides & Resources

lifestyle

Exercise for Heart Health: How Supplements Can Support Your Routine

Regular physical activity is unequivocally one of the most powerful interventions for cardiovascular health, with effects that rival or exceed many pharmaceutical treatments. The American …

lifestyle

The Mediterranean Diet and Heart Supplements: A Complete Guide

The Mediterranean diet stands as the most well-validated dietary pattern for cardiovascular disease prevention, supported by decades of epidemiological evidence and confirmed by the landmark …

safety

Taking Supplements While on Blood Thinners: Essential Cautions

Anticoagulant and antiplatelet medications — including warfarin, heparin, direct oral anticoagulants (DOACs such as apixaban, rivaroxaban, edoxaban, and dabigatran), aspirin, clopidogrel, and prasugrel — are …

View all 10 guides →

Evidence Grading System

Every supplement claim on this site is graded on an A–D scale based on peer-reviewed clinical research from PubMed. Our algorithm evaluates study design (RCTs rank highest), consistency of results, sample sizes, and the overall body of evidence. No manufacturer sponsorship influences our grades.

A Strong Evidence

Multiple randomized controlled trials (RCTs) or meta-analyses with consistent positive results and large sample sizes.

B Good Evidence

At least one RCT with mostly consistent results across studies. Evidence suggests benefit but more research may be needed.

C Some Evidence

Small studies or observational data with some positive signals. Promising but insufficient for strong recommendations.

D Very Early Research

In vitro studies, case reports, or pilot studies only. Early-stage research that requires clinical validation.

Read our full methodology →

How It Works

No ads. No sponsored rankings. Just science.

Search PubMed

We search PubMed for every clinical study on supplement ingredients.

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Extract Findings

We extract the key findings — sample sizes, study types, and results.

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Grade A through F

We grade the evidence like a school report card — from A (strong) to F (negative).

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Clear Answer

You get a clear answer in seconds — does this supplement actually work?

Cited Health Network

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Evidence-based brain and cognitive supplement reviews. Every claim about nootrop

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Evidence-based skin health supplement reviews. Every claim about collagen, vitam

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.