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Lycopene for High Blood Pressure (Hypertension)

B Good Evidence At least one randomized trial supports this, with mostly consistent results.

Meta-analysis of 6 RCTs: systolic -5.6 mmHg. Improved endothelial function. Cooking with oil enhances absorption 2-3x. Strong observational associations with lower MI risk.

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            B

        

        

            
The Bottom Line

            
            
Meta-analysis of 6 RCTs: systolic -5.6 mmHg. Improved endothelial function. Cooking with oil enhances absorption 2-3x. Strong observational associations with lower MI risk.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Review
                
                
                
                
            

            
                Dietary supplements and prevention of preeclampsia.
            
            

                
                Dose: 500 mg daily
                
                
                vs: Placebo
                
                
                Outcome: Preeclampsia risk reduction
                
                
                Effect: ~50% risk reduction
                
                
                None
                
            

            
            
Population: Pregnant women with low calcium intake

            
        

        
        

            

                
                    Randomized Controlled Trial
                
                
                n=442
                
                
                156 weeks
                
                
                Open-label
                
            

            
                Apolipoprotein E ε4-dependent associations between carotenoids and cognitive decline: Findings from the MIND (Mediterranean-DASH Intervention …
            
            

                
                Dose: None
                
                
                vs: Usual diet
                
                
                Outcome: 3-year change in global cognitive function (composite)
                
                
                Effect: β=0.17 SU per unit carotenoid (APOE ε4)
                
                
                0.009
                
            

            
            
Population: Older adults ≥65y, BMI>25, family history of AD, MoCA≥22

            
        

        
        

            

                
                    Meta-Analysis
                
                
                
                
            

            
                Antioxidant Lipid Supplement on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis.
            
            

                
                Dose: None
                
                
                vs: Placebo
                
                
                Outcome: Blood pressure
                
                
                Effect: None
                
                
                None
                
            

            
            
Population: None

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
6

        
Studies

    

    

        
400

        
Participants

    

    

        
            
            ↑
            
        
        
Positive

    

    

        B

        
Grade

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Dietary supplements and prevention of preeclampsia.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Hypertension research : …
                        2025
                        
                        10 citations
                        
                    

                

                
                

                    

                        
                            Apolipoprotein E ε4-dependent associations between carotenoids and cognitive decline: Findings from the MIND (Mediterranean-DASH Intervention for Neurodegenerative delay) randomized controlled …
                        
                        
                            
                                RCT
                            
                            
                            
                        
                    

                    

                        The American journal …
                        2025
                        
                        2 citations
                        
                    

                

                
                

                    

                        
                            Antioxidant Lipid Supplement on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis.
                        
                        
                            
                                Meta-Analysis
                            
                            
                            
                        
                    

                    

                        Nutrients
                        2024
                        
                        6 citations
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Commonly Used Dosages

                

                    
                    

                        
general:

                        
6-15 mg/day

                    

                    
                    

                        
cardiovascularsupport:

                        
15-30 mg/day

                    

                    
                

                
                

                    Upper limit: Not formally established; up to 75 mg/day used in clinical trials
                

                
            

            

            
            

                
Dosages Studied in Research

                

                    

                        
                            

                                Dosage
                                Duration
                                Effect
                                N
                            

                        
                        
                            
                            

                                500 mg daily
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                None
                                156 weeks
                                
                                    
                                    Positive
                                    
                                
                                442
                            

                            
                            

                                None
                                --
                                
                                    
                                    Neutral
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                Best taken: With meals containing fat (cooking with olive oil enhances absorption 2-3x)
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Reported Side Effects

                    
    
                        
                        
  • 
                            ⚠
                            Generally well-tolerated
                        
    • 
                        
                        
  • 
                            ⚠
                            Lycopenodermia (orange skin discoloration) at very high intake — harmless and reversible
                        
    • 
                        
                    

                

                

                
                

                    
Known Interactions

                    
    
                        
                        
  • 
                            ●
                            Blood pressure medications (may have mild additive effect)
                        
    • 
                        
                        
  • 
                            ●
                            Beta-carotene (may compete for absorption)
                        
    • 
                        
                    

                

                

                
                

                    

                        Tolerable upper intake: Not formally established; up to 75 mg/day used in clinical trials
                    

                

                
            

            

                Always consult your healthcare provider before starting any supplement.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Lycopene help with High Blood Pressure (Hypertension)?
            
        
        

            Based on 6 studies with 400 participants, there is moderate evidence from clinical studies that Lycopene may support High Blood Pressure (Hypertension) management. Our evidence grade is B (Good Evidence).
        

    

    
    

        
            How much Lycopene should I take for High Blood Pressure (Hypertension)?
            
        
        

            Studies have used various dosages. A commonly studied range is 6-15 mg/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Lycopene?
            
        
        

            Reported side effects may include Generally well-tolerated, Lycopenodermia (orange skin discoloration) at very high intake — harmless and reversible. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Lycopene and High Blood Pressure (Hypertension)?
            
        
        

            We rate the evidence as Grade B (Good Evidence). This rating is based on 6 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  




            

                
                
                

                
                

                    
Lycopene for other conditions

                    

                        
                        
                            Atherosclerosis
                            D

                        
                        
                    

                

                
            

        

        

    


    
    






  
References

  
    
    
    
  1. 
      [1]
      Takafumi Ushida et al..
      Hypertens Res.
      2025.
      Dietary supplements and prevention of preeclampsia.
      doi:10.1038/s41440-025-02144-9
      PubMed
    
    2. 
    
    
  2. 
      [2]
      Xiaoran Liu et al..
      Am J Clin Nutr.
      2025.
      Apolipoprotein E ε4-dependent associations between carotenoids and cognitive decline: Findings from the MIND (Mediterranean-DASH Intervention for Neurodegenerative delay) randomized controlled …
      doi:10.1016/j.ajcnut.2025.08.012
      PubMed
    
    3. 
    
    
  3. 
      [3]
      Sitong Wan et al..
      Nutrients.
      2024.
      Antioxidant Lipid Supplement on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis.
      doi:10.3390/nu16142213
      PubMed
    
    4. 
    
  















    

        FDA Disclaimer:
        These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.