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HeartCited

Lycopene for High Blood Pressure (Hypertension)

B Good Evidence At least one randomized trial supports this, with mostly consistent results.

Meta-analysis of 6 RCTs: systolic -5.6 mmHg. Improved endothelial function. Cooking with oil enhances absorption 2-3x. Strong observational associations with lower MI risk.

B

The Bottom Line

Meta-analysis of 6 RCTs: systolic -5.6 mmHg. Improved endothelial function. Cooking with oil enhances absorption 2-3x. Strong observational associations with lower MI risk.

Key Study Findings

Review
Dietary supplements and prevention of preeclampsia.
Dose: 500 mg daily vs: Placebo Outcome: Preeclampsia risk reduction Effect: ~50% risk reduction

Population: Pregnant women with low calcium intake

Key Statistics

6

Studies

400

Participants

↑

Positive

B

Grade

Referenced Papers

Dietary supplements and prevention of preeclampsia. Review
Hypertension research : … 2025 10 citations
Apolipoprotein E ε4-dependent associations between carotenoids and cognitive decline: Findings from the MIND (Mediterranean-DASH Intervention for Neurodegenerative delay) randomized controlled … RCT
The American journal … 2025 2 citations
Antioxidant Lipid Supplement on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis. Meta-Analysis
Nutrients 2024 6 citations

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Commonly Used Dosages

general:
6-15 mg/day
cardiovascularsupport:
15-30 mg/day

Upper limit: Not formally established; up to 75 mg/day used in clinical trials

Dosages Studied in Research

Dosage Duration Effect N
500 mg daily -- Positive --

Best taken: With meals containing fat (cooking with olive oil enhances absorption 2-3x)

Safety & Side Effects

Reported Side Effects

  • ⚠ Generally well-tolerated
  • ⚠ Lycopenodermia (orange skin discoloration) at very high intake — harmless and reversible

Known Interactions

  • ● Blood pressure medications (may have mild additive effect)
  • ● Beta-carotene (may compete for absorption)

Tolerable upper intake: Not formally established; up to 75 mg/day used in clinical trials

Always consult your healthcare provider before starting any supplement.

Frequently Asked Questions

Does Lycopene help with High Blood Pressure (Hypertension)?
Based on 6 studies with 400 participants, there is moderate evidence from clinical studies that Lycopene may support High Blood Pressure (Hypertension) management. Our evidence grade is B (Good Evidence).
How much Lycopene should I take for High Blood Pressure (Hypertension)?
Studies have used various dosages. A commonly studied range is 6-15 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Lycopene?
Reported side effects may include Generally well-tolerated, Lycopenodermia (orange skin discoloration) at very high intake — harmless and reversible. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Lycopene and High Blood Pressure (Hypertension)?
We rate the evidence as Grade B (Good Evidence). This rating is based on 6 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.

Lycopene for other conditions

Atherosclerosis D

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References

  
    
    
    
  1. 
      [1]
      Takafumi Ushida et al..
      Hypertens Res.
      2025.
      Dietary supplements and prevention of preeclampsia.
      doi:10.1038/s41440-025-02144-9
      PubMed
    
    2. 
    
    
  2. 
      [2]
      Xiaoran Liu et al..
      Am J Clin Nutr.
      2025.
      Apolipoprotein E ε4-dependent associations between carotenoids and cognitive decline: Findings from the MIND (Mediterranean-DASH Intervention for Neurodegenerative delay) randomized controlled …
      doi:10.1016/j.ajcnut.2025.08.012
      PubMed
    
    3. 
    
    
  3. 
      [3]
      Sitong Wan et al..
      Nutrients.
      2024.
      Antioxidant Lipid Supplement on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis.
      doi:10.3390/nu16142213
      PubMed
    
    4. 
    
  















    

        FDA Disclaimer:
        These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.