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Lycopene için High Blood Pressure (Hypertension)

B Kanıt Bunu büyük ölçüde tutarlı sonuçlarla en az bir randomize çalışma desteklemektedir.

Meta-analysis of 6 RCTs: systolic -5.6 mmHg. Improved endothelial function. Cooking with oil enhances absorption 2-3x. Strong observational associations with lower MI risk.

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Sonuç

            
            
Meta-analysis of 6 RCTs: systolic -5.6 mmHg. Improved endothelial function. Cooking with oil enhances absorption 2-3x. Strong observational associations with lower MI risk.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Review
                
                
                
                
            

            
                Dietary supplements and prevention of preeclampsia.
            
            

                
                Dose: 500 mg daily
                
                
                vs: Placebo
                
                
                Outcome: Preeclampsia risk reduction
                
                
                Etki: ~50% risk reduction
                
                
                None
                
            

            
            
Popülasyon: Pregnant women with low calcium intake

            
        

        
        

            

                
                    Randomized Controlled Trial
                
                
                n=442
                
                
                156 weeks
                
                
                Open-label
                
            

            
                Apolipoprotein E ε4-dependent associations between carotenoids and cognitive decline: Findings from the MIND (Mediterranean-DASH Intervention …
            
            

                
                Dose: None
                
                
                vs: Usual diet
                
                
                Outcome: 3-year change in global cognitive function (composite)
                
                
                Etki: β=0.17 SU per unit carotenoid (APOE ε4)
                
                
                0.009
                
            

            
            
Popülasyon: Older adults ≥65y, BMI>25, family history of AD, MoCA≥22

            
        

        
        

            

                
                    Meta-Analysis
                
                
                
                
            

            
                Antioxidant Lipid Supplement on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis.
            
            

                
                Dose: None
                
                
                vs: Placebo
                
                
                Outcome: Blood pressure
                
                
                Etki: None
                
                
                None
                
            

            
            
Popülasyon: None

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
6

        
Çalışmalar

    

    

        
400

        
Katılımcılar

    

    

        
            
            ↑
            
        
        
Positive

    

    

        B

        
Derece

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Dietary supplements and prevention of preeclampsia.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Hypertension research : …
                        2025
                        
                        10 atıf
                        
                    

                

                
                

                    

                        
                            Apolipoprotein E ε4-dependent associations between carotenoids and cognitive decline: Findings from the MIND (Mediterranean-DASH Intervention for Neurodegenerative delay) randomized controlled …
                        
                        
                            
                                RCT
                            
                            
                            
                        
                    

                    

                        The American journal …
                        2025
                        
                        2 atıf
                        
                    

                

                
                

                    

                        
                            Antioxidant Lipid Supplement on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis.
                        
                        
                            
                                Meta-Analysis
                            
                            
                            
                        
                    

                    

                        Nutrients
                        2024
                        
                        6 atıf
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Yaygın Kullanılan Dozajlar

                

                    
                    

                        
general:

                        
6-15 mg/day

                    

                    
                    

                        
cardiovascularsupport:

                        
15-30 mg/day

                    

                    
                

                
                

                    Üst sınır: Not formally established; up to 75 mg/day used in clinical trials
                

                
            

            

            
            

                
Araştırmalarda İncelenen Dozajlar

                

                    

                        
                            

                                Dozaj
                                Süre
                                Etki
                                N
                            

                        
                        
                            
                            

                                500 mg daily
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                None
                                156 weeks
                                
                                    
                                    Positive
                                    
                                
                                442
                            

                            
                            

                                None
                                --
                                
                                    
                                    Neutral
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                En iyi alım zamanı: With meals containing fat (cooking with olive oil enhances absorption 2-3x)
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Bildirilen Yan Etkiler

                    
    
                        
                        
  • 
                            ⚠
                            Generally well-tolerated
                        
    • 
                        
                        
  • 
                            ⚠
                            Lycopenodermia (orange skin discoloration) at very high intake — harmless and reversible
                        
    • 
                        
                    

                

                

                
                

                    
Bilinen Etkileşimler

                    
    
                        
                        
  • 
                            ●
                            Blood pressure medications (may have mild additive effect)
                        
    • 
                        
                        
  • 
                            ●
                            Beta-carotene (may compete for absorption)
                        
    • 
                        
                    

                

                

                
                

                    

                        Tolere edilebilir üst alım: Not formally established; up to 75 mg/day used in clinical trials
                    

                

                
            

            

                Herhangi bir takviye kullanmaya başlamadan önce mutlaka sağlık uzmanınıza danışın.Herhangi bir takviye başlatmadan önce her zaman sağlık uzmanınıza danışın.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Lycopene help with High Blood Pressure (Hypertension)?
            
        
        

            Based on 6 studies with 400 participants, there is moderate evidence from clinical studies that Lycopene may support High Blood Pressure (Hypertension) management. Our evidence grade is B (Good Evidence).
        

    

    
    

        
            How much Lycopene should I take for High Blood Pressure (Hypertension)?
            
        
        

            Studies have used various dosages. A commonly studied range is 6-15 mg/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Lycopene?
            
        
        

            Reported side effects may include Generally well-tolerated, Lycopenodermia (orange skin discoloration) at very high intake — harmless and reversible. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Lycopene and High Blood Pressure (Hypertension)?
            
        
        

            We rate the evidence as Grade B (Good Evidence). This rating is based on 6 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  




            

                
                

                    
Şu durum için diğer içerikler: High Blood Pressure (Hypertension)

                    

                        
                        
                            Beetroot Extract
                            A

                        
                        
                        
                            Garlic
                            A

                        
                        
                        
                            Magnesium
                            B

                        
                        
                        
                            Potassium
                            B

                        
                        
                        
                            Quercetin
                            B

                        
                        
                        
                            Grape Seed Extract
                            B

                        
                        
                    

                

                

                
                

                    
Lycopene diğer sağlık durumları için

                    

                        
                        
                            Atherosclerosis
                            D

                        
                        
                    

                

                
            

        

        

    


    
    






  
References

  
    
    
    
  1. 
      [1]
      Takafumi Ushida et al..
      Hypertens Res.
      2025.
      Dietary supplements and prevention of preeclampsia.
      doi:10.1038/s41440-025-02144-9
      PubMed
    
    2. 
    
    
  2. 
      [2]
      Xiaoran Liu et al..
      Am J Clin Nutr.
      2025.
      Apolipoprotein E ε4-dependent associations between carotenoids and cognitive decline: Findings from the MIND (Mediterranean-DASH Intervention for Neurodegenerative delay) randomized controlled …
      doi:10.1016/j.ajcnut.2025.08.012
      PubMed
    
    3. 
    
    
  3. 
      [3]
      Sitong Wan et al..
      Nutrients.
      2024.
      Antioxidant Lipid Supplement on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis.
      doi:10.3390/nu16142213
      PubMed
    
    4. 
    
  















    

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