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Vitamin D
Vitamin D

vitamin

别名: Cholecalciferol (D3), Ergocalciferol (D2), Calciferol, Calcidiol

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About





            

                
Vitamin D binds to receptors on cardiomyocytes, vascular smooth muscle, and endothelial cells, regulating calcium handling and the renin-angiotensin-aldosterone system. Observational studies show deficiency (<20 ng/mL) is associated with 50-80% increased cardiovascular risk, though the VITAL trial (25,871 participants) found supplementation did not significantly reduce major cardiovascular events.

            

        

        

        
        
        

            

  
How It Works





            

                
Binds to vitamin D receptors (VDR) on cardiomyocytes, vascular smooth muscle, and endothelial cells regulating calcium handling and contractile function; modulates the renin-angiotensin-aldosterone system (RAAS) — deficiency upregulates renin contributing to hypertension; suppresses vascular inflammation via NF-kB inhibition; supports endothelial nitric oxide synthase (eNOS) expression.

            

        

        

        
        
        

            

  
Evidence For Conditions





            

                

                    

                        
                            

                                健康状况
                                等级
                                研究数量
                                受试者
                                
                            

                        
                        
                            
                            

                                
                                    
                                        High Blood Pressure (Hypertension)
                                    
                                
                                
                                    C

                                
                                
                                    20
                                
                                
                                    30000
                                
                                
                                    
                                        查看 →
                                    
                                
                            

                            
                            

                                
                                    
                                        Heart Failure
                                    
                                
                                
                                    C

                                
                                
                                    6
                                
                                
                                    3000
                                
                                
                                    
                                        查看 →
                                    
                                
                            

                            
                        
                    

                

            

        

        

        
        
        

            

  
Side Effects





            
    
                
                
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                    Hypercalcemia at very high doses (fatigue, nausea, kidney stones)
                
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                    Constipation
                
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                    Generally very safe at recommended doses
                
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Drug & Supplement Interactions





            
    
                
                
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                    Thiazide diuretics (may increase hypercalcemia risk)
                
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                    Statins (theoretical interaction via CYP enzymes)
                
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                    Corticosteroids (may reduce vitamin D absorption)
                
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                    Weight loss medications (may reduce absorption of fat-soluble vitamins)
                
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                请务必告知您的医疗保健提供者您正在服用的所有补充剂。
            

        

        

        
        
        

            

  
Related Ingredients





            

                
                
                    Vitamin K2
                    
                
                
                
                    Niacin (Vitamin B3)
                    
                
                
                
                    Folate (Vitamin B9)
                    
                
                
                
                    Vitamin E
                    
                
                
            

        

        
    


    
    












    

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