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Folate (Vitamin B9)
Folate (Vitamin B9)

vitamin

别名: Folic Acid, L-Methylfolate, 5-MTHF, Vitamin B9

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About





            

                
Folate is essential for one-carbon metabolism and converts homocysteine to methionine, directly reducing plasma homocysteine — an independent cardiovascular risk factor. The CSPPT trial (20,702 hypertensive adults) found folic acid at 800 mcg/day reduced first stroke by 21%, though Western trials in folic acid-fortified populations showed less benefit.

            

        

        

        
        
        

            

  
How It Works





            

                
Essential cofactor in one-carbon metabolism; converts homocysteine to methionine via methionine synthase (with B12), directly reducing plasma homocysteine levels — an independent cardiovascular risk factor; supports endothelial function by enhancing nitric oxide production through tetrahydrobiopterin (BH4) recycling.

            

        

        

        
        
        

            

  
Evidence For Conditions





            

                

                    

                        
                            

                                健康状况
                                等级
                                研究数量
                                受试者
                                
                            

                        
                        
                            
                            

                                
                                    
                                        Elevated Homocysteine (Hyperhomocysteinemia)
                                    
                                
                                
                                    B

                                
                                
                                    30
                                
                                
                                    30000
                                
                                
                                    
                                        查看 →
                                    
                                
                            

                            
                            

                                
                                    
                                        Coronary Artery Disease (CAD)
                                    
                                
                                
                                    C

                                
                                
                                    10
                                
                                
                                    40000
                                
                                
                                    
                                        查看 →
                                    
                                
                            

                            
                        
                    

                

            

        

        

        
        
        

            

  
Side Effects





            
    
                
                
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                    Generally very well-tolerated
                
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                    May mask vitamin B12 deficiency at high doses
                
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                    Rare: mild gastrointestinal discomfort
                
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Drug & Supplement Interactions





            
    
                
                
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                    Methotrexate (folate may reduce efficacy)
                
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                    Antiepileptic drugs (phenytoin, carbamazepine — mutual interference)
                
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                    Vitamin B12 (co-supplementation recommended for homocysteine reduction)
                
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                请务必告知您的医疗保健提供者您正在服用的所有补充剂。
            

        

        

        
        
        

            

  
Related Ingredients





            

                
                
                    Vitamin D
                    
                
                
                
                    Vitamin K2
                    
                
                
                
                    Niacin (Vitamin B3)
                    
                
                
                
                    Vitamin E
                    
                
                
            

        

        
    


    
    












    

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