Folate (Vitamin B9) 用于冠状动脉疾病（CAD）

Q: Does Folate (Vitamin B9) help with 冠状动脉疾病（CAD）?

Based on 10 studies with 40,000 participants, there is limited but promising evidence that Folate (Vitamin B9) may support 冠状动脉疾病（CAD） management. Our evidence grade is C (Some Evidence).

Q: How much Folate (Vitamin B9) should I take for 冠状动脉疾病（CAD）?

Studies have used various dosages. A commonly studied range is 400 mcg DFE/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Folate (Vitamin B9)?

Reported side effects may include Generally very well-tolerated, May mask vitamin B12 deficiency at high doses, Rare: mild gastrointestinal discomfort. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Folate (Vitamin B9) and 冠状动脉疾病（CAD）?

We rate the evidence as Grade C (Some Evidence). This rating is based on 10 peer-reviewed studies with 40,000 total participants. The overall direction of effect is mixed.

C 证据来自小型研究的证据有限，但存在一些积极信号。

CSPPT showed stroke benefit but not MI benefit. HOPE-2 was negative for cardiovascular events despite homocysteine reduction. Research suggests benefit may be limited to populations without folic acid fortification.

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结论

Key Study Findings

cross-sectional n=800

Excessive Daytime Sleepiness is Associated With Malnutrition, Dysphagia, and Vitamin D Deficiency in Older Adults.

Dose: None vs: Placebo 效果: OR 1.73 (malnutrition), OR 2.01 (dysphagia), OR 2.0 (vitamin D deficiency) <0.05

Meta-Analysis n=129

Effects of Nutritional Supplements and Dietary Interventions on Cardiovascular Outcomes: An Umbrella Review and Evidence …

Dose: None vs: None Outcome: Mortality 效果: None None

研究人群: None

Review

Folic acid and diseases - supplement it or not?

Dose: None vs: Placebo 效果: None None

Review

Prevention of strokes.

Dose: Antiplatelet, antihypertensives, statins vs: None Outcome: Stroke prevention 效果: None None

研究人群: Stroke-risk population

Key Statistics

研究数量

40000

受试者

↔

Mixed

等级

Referenced Papers

Excessive Daytime Sleepiness is Associated With Malnutrition, Dysphagia, and Vitamin D Deficiency in Older Adults. Other

Journal of the … 2021 22 次引用

Effects of Nutritional Supplements and Dietary Interventions on Cardiovascular Outcomes: An Umbrella Review and Evidence Map. Meta-Analysis

Annals of internal … 2019 133 次引用

Folic acid and diseases - supplement it or not? Review

Revista da Associacao … 2016 62 次引用

Prevention of strokes. Review

Current atherosclerosis reports 2001 2 次引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

常用剂量

general:: 400 mcg DFE/day
homocysteinereduction:: 400-800 mcg/day folic acid (with B12 and B6)

上限： 1,000 mcg/day folic acid from supplements

研究中使用的剂量

剂量	持续时间	效果	N
None	--	Positive	800
None	--	Neutral	129
None	--	Mixed	--
Antiplatelet, antihypertensives, statins	--	Positive	--

最佳服用时间： With or without food; consistent daily timing preferred

Safety & Side Effects

已报告的副作用

⚠ Generally very well-tolerated
⚠ May mask vitamin B12 deficiency at high doses
⚠ Rare: mild gastrointestinal discomfort

已知相互作用

● Methotrexate (folate may reduce efficacy)
● Antiepileptic drugs (phenytoin, carbamazepine — mutual interference)
● Vitamin B12 (co-supplementation recommended for homocysteine reduction)

可耐受最高摄入量： 1,000 mcg/day folic acid from supplements

在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。

Frequently Asked Questions

Does Folate (Vitamin B9) help with 冠状动脉疾病（CAD）?

Based on 10 studies with 40,000 participants, there is limited but promising evidence that Folate (Vitamin B9) may support 冠状动脉疾病（CAD） management. Our evidence grade is C (Some Evidence).

How much Folate (Vitamin B9) should I take for 冠状动脉疾病（CAD）?

Studies have used various dosages. A commonly studied range is 400 mcg DFE/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Folate (Vitamin B9)?

Reported side effects may include Generally very well-tolerated, May mask vitamin B12 deficiency at high doses, Rare: mild gastrointestinal discomfort. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Folate (Vitamin B9) and 冠状动脉疾病（CAD）?

We rate the evidence as Grade C (Some Evidence). This rating is based on 10 peer-reviewed studies with 40,000 total participants. The overall direction of effect is mixed.

其他成分用于冠状动脉疾病（CAD）

Omega-3 Fatty Acids (EPA/DHA) B Magnesium C Selenium C

Folate (Vitamin B9) 用于其他健康状况

高同型半胱氨酸血症 B

快速结论

Evidence Strength52%

Moderate confidence

研究分析

RCT (0)Meta (1)Other (9)

对比替代方案

查看其他成分针对该健康状况的对比结果。

查看所有成分用于冠状动脉疾病（CAD）

了解更多

References

[1] Saadet Koc Okudur et al.. J Am Med Dir Assoc. 2021. Excessive Daytime Sleepiness is Associated With Malnutrition, Dysphagia, and Vitamin D Deficiency in Older Adults. doi:10.1016/j.jamda.2021.05.035 PubMed
[2] Safi U Khan et al.. Ann Intern Med. 2019. Effects of Nutritional Supplements and Dietary Interventions on Cardiovascular Outcomes: An Umbrella Review and Evidence Map. doi:10.7326/M19-0341 PubMed
[3] Siaw-Cheok Liew. Rev Assoc Med Bras (1992). 2016. Folic acid and diseases - supplement it or not? doi:10.1590/1806-9282.62.01.90 PubMed
[4] T J Jeerakathil et al.. Curr Atheroscler Rep. 2001. Prevention of strokes. doi:10.1007/s11883-001-0026-7 PubMed

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