Folate (Vitamin B9) 用于 高同型半胱氨酸血症
B 证据 至少一项随机试验支持这一结论,结果基本一致。Consistently reduces homocysteine 20-30%. CSPPT: 21% stroke reduction in unfortified Chinese population. Research suggests less benefit in folic acid-fortified populations.
结论
Consistently reduces homocysteine 20-30%. CSPPT: 21% stroke reduction in unfortified Chinese population. Research suggests less benefit in folic acid-fortified populations.
Key Study Findings
研究人群: Individuals with hyperhomocysteinemia (review)
研究人群: Early Parkinson's disease patients
研究人群: None
研究人群: Older adults and at-risk B12 deficient individuals
Key Statistics
30
研究数量
30000
受试者
Positive
等级
Referenced Papers
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 400 mcg DFE/day
- homocysteinereduction:
- 400-800 mcg/day folic acid (with B12 and B6)
上限: 1,000 mcg/day folic acid from supplements
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Positive | -- |
| varies across 52 included studies | -- | Mixed | 10429 |
| Vitamin B12 (measured, not supplemented) | -- | Positive | -- |
| variable across included studies | -- | Positive | -- |
| 30 g | -- | Positive | -- |
| >5 mg/day | -- | Negative | -- |
| Homocysteine, folate, B12 (measured) | -- | Positive | 246 |
| Enhanced vitamin supplement (riboflavin, vitamins B6, B12, D, myo-inositol, probiotics, zinc + stand | -- | Positive | 1729 |
最佳服用时间: With or without food; consistent daily timing preferred
Safety & Side Effects
已报告的副作用
- ⚠ Generally very well-tolerated
- ⚠ May mask vitamin B12 deficiency at high doses
- ⚠ Rare: mild gastrointestinal discomfort
已知相互作用
- ● Methotrexate (folate may reduce efficacy)
- ● Antiepileptic drugs (phenytoin, carbamazepine — mutual interference)
- ● Vitamin B12 (co-supplementation recommended for homocysteine reduction)
可耐受最高摄入量: 1,000 mcg/day folic acid from supplements
在开始服用任何补充剂之前,请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Folate (Vitamin B9) help with 高同型半胱氨酸血症?
How much Folate (Vitamin B9) should I take for 高同型半胱氨酸血症?
Are there side effects of Folate (Vitamin B9)?
How strong is the evidence for Folate (Vitamin B9) and 高同型半胱氨酸血症?
Related Evidence
Folate (Vitamin B9) 用于其他健康状况
References
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