Folate (Vitamin B9) ： Elevated Homocysteine (Hyperhomocysteinemia)
B エビデンス 少なくとも1件のランダム化試験がこれを支持しており、おおむね一貫した結果が得られています。Consistently reduces homocysteine 20-30%. CSPPT: 21% stroke reduction in unfortified Chinese population. Research suggests less benefit in folic acid-fortified populations.
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B
結論
Consistently reduces homocysteine 20-30%. CSPPT: 21% stroke reduction in unfortified Chinese population. Research suggests less benefit in folic acid-fortified populations.
Key Study Findings
Review
Homocysteine, Nutrition, and Gut Microbiota: A Comprehensive Review of Current Evidence and Insights.
Dose: None
vs: None
Outcome: Homocysteine levels and related disease progression
効果: None
None
対象集団: Individuals with hyperhomocysteinemia (review)
systematic review
n=10429
Folic acid and autism: updated evidences.
Dose: varies across 52 included studies
vs: Placebo
効果: improvements in communication, socialization, and behavior following folic acid interventions; no as
None
Randomized Controlled Trial
Double-blind
Relationships of B12 and Homocysteine with Outcomes in the SURE-PD, SURE-PD3, and STEADY-PDIII Trials.
Dose: Vitamin B12 (measured, not supplemented)
vs: Within-trial comparison
Outcome: B12/homocysteine association with PD outcomes
効果: None
None
対象集団: Early Parkinson's disease patients
systematic review and meta-analysis
The effect of B-vitamins on the prevention and treatment of cardiovascular diseases: a systematic review …
Dose: variable across included studies
vs: Placebo
効果: folic acid significantly reduced carotid intima-media thickness; higher B6, B12, folate associated w
not fully specified in abstrac
Case-Control
Maternal multivitamin supplementation mitigates the risk of fetal congenital heart disease associated with high indoor …
Dose: 30 g
vs: None
Outcome: None
効果: None
None
対象集団: None
Review
Excess Folic Acid and Vitamin B12 Deficiency: Clinical Implications?
Dose: >5 mg/day
vs: None
Outcome: B12 deficiency exacerbation by excess folic acid
効果: None
None
対象集団: Older adults and at-risk B12 deficient individuals
Key Statistics
30
研究数
30000
参加者数
↑
Positive
B
グレード
Referenced Papers
Nutritional neuroscience
2025
9 件の引用
Nutrients
2025
5 件の引用
Food and nutrition …
2024
19 件の引用
The effect of B-vitamins on the prevention and treatment of cardiovascular diseases: a systematic review and meta-analysis.
Meta-Analysis
Nutrition reviews
2024
17 件の引用
Environmental health : …
2024
7 件の引用
Journal of Parkinson's …
2024
1 件の引用
Homocysteine levels, genetic background, and cognitive impairment in Parkinson's disease.
Meta-Analysis
Journal of neurology
2023
34 件の引用
PLoS medicine
2023
19 件の引用
Molecular and cellular …
2023
8 件の引用
The British journal …
2023
6 件の引用
The Journal of …
2023
6 件の引用
The Journal of …
2023
4 件の引用
Vitamins and hormones
2022
28 件の引用
Current nutrition reports
2022
25 件の引用
Cellular and molecular …
2022
20 件の引用
Folate Supplementation in Fertility and Pregnancy: The Advantages of (6S)5-Methyltetrahydrofolate.
Other
Alternative therapies in …
2022
16 件の引用
European journal of …
2022
7 件の引用
[Not Available].
Other
Tidsskrift for den …
2022
European journal of …
2021
60 件の引用
Medical hypotheses
2021
24 件の引用
European journal of …
2020
87 件の引用
International journal for …
2020
34 件の引用
Systematic reviews
2020
29 件の引用
Journal of nutritional …
2019
34 件の引用
Medical hypotheses
2019
15 件の引用
Journal of Alzheimer's …
2018
281 件の引用
The Cochrane database …
2018
128 件の引用
Annals of surgical …
2018
22 件の引用
The American journal …
2018
17 件の引用
Congenital anomalies
2017
149 件の引用
Neurobiology of disease
2017
62 件の引用
International angiology : …
2017
15 件の引用
Annual review of …
2016
432 件の引用
Journal of Alzheimer's …
2016
128 件の引用
Nutrients
2016
114 件の引用
Revista da Associacao …
2016
62 件の引用
The journal of …
2015
25 件の引用
Current opinion in …
2015
21 件の引用
PloS one
2014
106 件の引用
JAMA ophthalmology
2014
60 件の引用
Clinical nutrition (Edinburgh, …
2014
18 件の引用
Maternal & child …
2013
112 件の引用
Current opinion in …
2013
64 件の引用
Current osteoporosis reports
2013
43 件の引用
Kidney & blood …
2013
43 件の引用
Nutrition journal
2013
26 件の引用
Ontario health technology …
2013
The British journal …
2012
40 件の引用
European review for …
2011
9 件の引用
Poultry science
2010
17 件の引用
Homocysteine, vitamin B12, folate and cognitive functions: a systematic and critical review of the literature.
Systematic Review
International journal of …
2009
125 件の引用
Neurology
2009
124 件の引用
Alternative medicine review …
2008
International journal of …
2006
61 件の引用
The New England …
2006
47 件の引用
Journal of Alzheimer's …
2006
37 件の引用
Climacteric : the …
2006
Neurology India
2004
71 件の引用
The international journal …
2004
70 件の引用
Clinical chemistry
2004
40 件の引用
Folic acid with or without vitamin B12 for cognition and dementia.
Systematic Review
The Cochrane database …
2003
263 件の引用
International journal for …
2002
33 件の引用
Prevention of strokes.
Review
Current atherosclerosis reports
2001
2 件の引用
The American journal …
2000
667 件の引用
Seminars in thrombosis …
2000
194 件の引用
The British journal …
2000
44 件の引用
International journal for …
1999
14 件の引用
Alternative medicine review …
1998
58 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 400 mcg DFE/day
- homocysteinereduction:
- 400-800 mcg/day folic acid (with B12 and B6)
上限量： 1,000 mcg/day folic acid from supplements
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Positive | -- |
| varies across 52 included studies | -- | Mixed | 10429 |
| Vitamin B12 (measured, not supplemented) | -- | Positive | -- |
| variable across included studies | -- | Positive | -- |
| 30 g | -- | Positive | -- |
| >5 mg/day | -- | Negative | -- |
| Homocysteine, folate, B12 (measured) | -- | Positive | 246 |
| Enhanced vitamin supplement (riboflavin, vitamins B6, B12, D, myo-inositol, probiotics, zinc + stand | -- | Positive | 1729 |
推奨摂取タイミング： With or without food; consistent daily timing preferred
Safety & Side Effects
報告されている副作用
- ⚠ Generally very well-tolerated
- ⚠ May mask vitamin B12 deficiency at high doses
- ⚠ Rare: mild gastrointestinal discomfort
既知の相互作用
- ● Methotrexate (folate may reduce efficacy)
- ● Antiepileptic drugs (phenytoin, carbamazepine — mutual interference)
- ● Vitamin B12 (co-supplementation recommended for homocysteine reduction)
耐容上限摂取量： 1,000 mcg/day folic acid from supplements
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Folate (Vitamin B9) help with Elevated Homocysteine (Hyperhomocysteinemia)?
Based on 30 studies with 30,000 participants, there is moderate evidence from clinical studies that Folate (Vitamin B9) may support Elevated Homocysteine (Hyperhomocysteinemia) management. Our evidence grade is B (Good Evidence).
How much Folate (Vitamin B9) should I take for Elevated Homocysteine (Hyperhomocysteinemia)?
Studies have used various dosages. A commonly studied range is 400 mcg DFE/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Folate (Vitamin B9)?
Reported side effects may include Generally very well-tolerated, May mask vitamin B12 deficiency at high doses, Rare: mild gastrointestinal discomfort. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Folate (Vitamin B9) and Elevated Homocysteine (Hyperhomocysteinemia)?
We rate the evidence as Grade B (Good Evidence). This rating is based on 30 peer-reviewed studies with 30,000 total participants. The overall direction of effect is positive.
Related Evidence
Folate (Vitamin B9) 他の症状・状態について
References
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