Folate (Vitamin B9) für Elevated Homocysteine (Hyperhomocysteinemia)
B Evidenz Mindestens eine randomisierte Studie unterstützt dies, mit überwiegend konsistenten Ergebnissen.Consistently reduces homocysteine 20-30%. CSPPT: 21% stroke reduction in unfortified Chinese population. Research suggests less benefit in folic acid-fortified populations.
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B
Fazit
Consistently reduces homocysteine 20-30%. CSPPT: 21% stroke reduction in unfortified Chinese population. Research suggests less benefit in folic acid-fortified populations.
Key Study Findings
Review
Homocysteine, Nutrition, and Gut Microbiota: A Comprehensive Review of Current Evidence and Insights.
Dose: None
vs.: None
Outcome: Homocysteine levels and related disease progression
Wirkung: None
None
Population: Individuals with hyperhomocysteinemia (review)
systematic review
n=10429
Folic acid and autism: updated evidences.
Dose: varies across 52 included studies
vs.: Placebo
Wirkung: improvements in communication, socialization, and behavior following folic acid interventions; no as
None
Randomized Controlled Trial
Double-blind
Relationships of B12 and Homocysteine with Outcomes in the SURE-PD, SURE-PD3, and STEADY-PDIII Trials.
Dose: Vitamin B12 (measured, not supplemented)
vs.: Within-trial comparison
Outcome: B12/homocysteine association with PD outcomes
Wirkung: None
None
Population: Early Parkinson's disease patients
systematic review and meta-analysis
The effect of B-vitamins on the prevention and treatment of cardiovascular diseases: a systematic review …
Dose: variable across included studies
vs.: Placebo
Wirkung: folic acid significantly reduced carotid intima-media thickness; higher B6, B12, folate associated w
not fully specified in abstrac
Case-Control
Maternal multivitamin supplementation mitigates the risk of fetal congenital heart disease associated with high indoor …
Dose: 30 g
vs.: None
Outcome: None
Wirkung: None
None
Population: None
Review
Excess Folic Acid and Vitamin B12 Deficiency: Clinical Implications?
Dose: >5 mg/day
vs.: None
Outcome: B12 deficiency exacerbation by excess folic acid
Wirkung: None
None
Population: Older adults and at-risk B12 deficient individuals
Key Statistics
30
Studien
30000
Teilnehmer
↑
Positive
B
Bewertung
Referenced Papers
Nutritional neuroscience
2025
9 Zitierungen
Nutrients
2025
5 Zitierungen
Food and nutrition …
2024
19 Zitierungen
The effect of B-vitamins on the prevention and treatment of cardiovascular diseases: a systematic review and meta-analysis.
Meta-Analysis
Nutrition reviews
2024
17 Zitierungen
Environmental health : …
2024
7 Zitierungen
Journal of Parkinson's …
2024
1 Zitierungen
Homocysteine levels, genetic background, and cognitive impairment in Parkinson's disease.
Meta-Analysis
Journal of neurology
2023
34 Zitierungen
PLoS medicine
2023
19 Zitierungen
Molecular and cellular …
2023
8 Zitierungen
The British journal …
2023
6 Zitierungen
The Journal of …
2023
6 Zitierungen
The Journal of …
2023
4 Zitierungen
Vitamins and hormones
2022
28 Zitierungen
Current nutrition reports
2022
25 Zitierungen
Cellular and molecular …
2022
20 Zitierungen
Folate Supplementation in Fertility and Pregnancy: The Advantages of (6S)5-Methyltetrahydrofolate.
Other
Alternative therapies in …
2022
16 Zitierungen
European journal of …
2022
7 Zitierungen
[Not Available].
Other
Tidsskrift for den …
2022
European journal of …
2021
60 Zitierungen
Medical hypotheses
2021
24 Zitierungen
European journal of …
2020
87 Zitierungen
International journal for …
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34 Zitierungen
Systematic reviews
2020
29 Zitierungen
Journal of nutritional …
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Medical hypotheses
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Congenital anomalies
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Neurobiology of disease
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International angiology : …
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Annual review of …
2016
432 Zitierungen
Journal of Alzheimer's …
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Nutrients
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Clinical nutrition (Edinburgh, …
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Nutrition journal
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Ontario health technology …
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The British journal …
2012
40 Zitierungen
European review for …
2011
9 Zitierungen
Poultry science
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Homocysteine, vitamin B12, folate and cognitive functions: a systematic and critical review of the literature.
Systematic Review
International journal of …
2009
125 Zitierungen
Neurology
2009
124 Zitierungen
Alternative medicine review …
2008
International journal of …
2006
61 Zitierungen
The New England …
2006
47 Zitierungen
Journal of Alzheimer's …
2006
37 Zitierungen
Climacteric : the …
2006
Neurology India
2004
71 Zitierungen
The international journal …
2004
70 Zitierungen
Clinical chemistry
2004
40 Zitierungen
Folic acid with or without vitamin B12 for cognition and dementia.
Systematic Review
The Cochrane database …
2003
263 Zitierungen
International journal for …
2002
33 Zitierungen
Prevention of strokes.
Review
Current atherosclerosis reports
2001
2 Zitierungen
The American journal …
2000
667 Zitierungen
Seminars in thrombosis …
2000
194 Zitierungen
The British journal …
2000
44 Zitierungen
International journal for …
1999
14 Zitierungen
Alternative medicine review …
1998
58 Zitierungen
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Übliche Dosierungen
- general:
- 400 mcg DFE/day
- homocysteinereduction:
- 400-800 mcg/day folic acid (with B12 and B6)
Obergrenze: 1,000 mcg/day folic acid from supplements
In der Forschung untersuchte Dosierungen
| Dosierung | Dauer | Wirkung | N |
|---|---|---|---|
| None | -- | Positive | -- |
| varies across 52 included studies | -- | Mixed | 10429 |
| Vitamin B12 (measured, not supplemented) | -- | Positive | -- |
| variable across included studies | -- | Positive | -- |
| 30 g | -- | Positive | -- |
| >5 mg/day | -- | Negative | -- |
| Homocysteine, folate, B12 (measured) | -- | Positive | 246 |
| Enhanced vitamin supplement (riboflavin, vitamins B6, B12, D, myo-inositol, probiotics, zinc + stand | -- | Positive | 1729 |
Beste Einnahmezeit: With or without food; consistent daily timing preferred
Safety & Side Effects
Gemeldete Nebenwirkungen
- ⚠ Generally very well-tolerated
- ⚠ May mask vitamin B12 deficiency at high doses
- ⚠ Rare: mild gastrointestinal discomfort
Bekannte Wechselwirkungen
- ● Methotrexate (folate may reduce efficacy)
- ● Antiepileptic drugs (phenytoin, carbamazepine — mutual interference)
- ● Vitamin B12 (co-supplementation recommended for homocysteine reduction)
Tolerierbare Höchstaufnahmemenge: 1,000 mcg/day folic acid from supplements
Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.
Frequently Asked Questions
Does Folate (Vitamin B9) help with Elevated Homocysteine (Hyperhomocysteinemia)?
Based on 30 studies with 30,000 participants, there is moderate evidence from clinical studies that Folate (Vitamin B9) may support Elevated Homocysteine (Hyperhomocysteinemia) management. Our evidence grade is B (Good Evidence).
How much Folate (Vitamin B9) should I take for Elevated Homocysteine (Hyperhomocysteinemia)?
Studies have used various dosages. A commonly studied range is 400 mcg DFE/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Folate (Vitamin B9)?
Reported side effects may include Generally very well-tolerated, May mask vitamin B12 deficiency at high doses, Rare: mild gastrointestinal discomfort. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Folate (Vitamin B9) and Elevated Homocysteine (Hyperhomocysteinemia)?
We rate the evidence as Grade B (Good Evidence). This rating is based on 30 peer-reviewed studies with 30,000 total participants. The overall direction of effect is positive.
Related Evidence
Folate (Vitamin B9) für andere Beschwerden
References
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