Folate (Vitamin B9) cho Elevated Homocysteine (Hyperhomocysteinemia)
B Bằng chứng Ít nhất một thử nghiệm ngẫu nhiên ủng hộ điều này, với các kết quả phần lớn nhất quán.Consistently reduces homocysteine 20-30%. CSPPT: 21% stroke reduction in unfortified Chinese population. Research suggests less benefit in folic acid-fortified populations.
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B
Kết luận
Consistently reduces homocysteine 20-30%. CSPPT: 21% stroke reduction in unfortified Chinese population. Research suggests less benefit in folic acid-fortified populations.
Key Study Findings
Review
Homocysteine, Nutrition, and Gut Microbiota: A Comprehensive Review of Current Evidence and Insights.
Dose: None
so với: None
Outcome: Homocysteine levels and related disease progression
Hiệu quả: None
None
Đối tượng nghiên cứu: Individuals with hyperhomocysteinemia (review)
systematic review
n=10429
Folic acid and autism: updated evidences.
Dose: varies across 52 included studies
so với: Placebo
Hiệu quả: improvements in communication, socialization, and behavior following folic acid interventions; no as
None
Randomized Controlled Trial
Double-blind
Relationships of B12 and Homocysteine with Outcomes in the SURE-PD, SURE-PD3, and STEADY-PDIII Trials.
Dose: Vitamin B12 (measured, not supplemented)
so với: Within-trial comparison
Outcome: B12/homocysteine association with PD outcomes
Hiệu quả: None
None
Đối tượng nghiên cứu: Early Parkinson's disease patients
systematic review and meta-analysis
The effect of B-vitamins on the prevention and treatment of cardiovascular diseases: a systematic review …
Dose: variable across included studies
so với: Placebo
Hiệu quả: folic acid significantly reduced carotid intima-media thickness; higher B6, B12, folate associated w
not fully specified in abstrac
Case-Control
Maternal multivitamin supplementation mitigates the risk of fetal congenital heart disease associated with high indoor …
Dose: 30 g
so với: None
Outcome: None
Hiệu quả: None
None
Đối tượng nghiên cứu: None
Review
Excess Folic Acid and Vitamin B12 Deficiency: Clinical Implications?
Dose: >5 mg/day
so với: None
Outcome: B12 deficiency exacerbation by excess folic acid
Hiệu quả: None
None
Đối tượng nghiên cứu: Older adults and at-risk B12 deficient individuals
Key Statistics
30
Nghiên cứu
30000
Người tham gia
↑
Positive
B
Xếp hạng
Referenced Papers
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2025
9 trích dẫn
Nutrients
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5 trích dẫn
Food and nutrition …
2024
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The effect of B-vitamins on the prevention and treatment of cardiovascular diseases: a systematic review and meta-analysis.
Meta-Analysis
Nutrition reviews
2024
17 trích dẫn
Environmental health : …
2024
7 trích dẫn
Journal of Parkinson's …
2024
1 trích dẫn
Homocysteine levels, genetic background, and cognitive impairment in Parkinson's disease.
Meta-Analysis
Journal of neurology
2023
34 trích dẫn
PLoS medicine
2023
19 trích dẫn
Molecular and cellular …
2023
8 trích dẫn
The British journal …
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Vitamins and hormones
2022
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Current nutrition reports
2022
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Cellular and molecular …
2022
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Folate Supplementation in Fertility and Pregnancy: The Advantages of (6S)5-Methyltetrahydrofolate.
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Clinical chemistry
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Prevention of strokes.
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Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Liều lượng thường dùng
- general:
- 400 mcg DFE/day
- homocysteinereduction:
- 400-800 mcg/day folic acid (with B12 and B6)
Giới hạn trên: 1,000 mcg/day folic acid from supplements
Liều lượng đã nghiên cứu
| Liều lượng | Thời gian | Hiệu quả | N |
|---|---|---|---|
| None | -- | Positive | -- |
| varies across 52 included studies | -- | Mixed | 10429 |
| Vitamin B12 (measured, not supplemented) | -- | Positive | -- |
| variable across included studies | -- | Positive | -- |
| 30 g | -- | Positive | -- |
| >5 mg/day | -- | Negative | -- |
| Homocysteine, folate, B12 (measured) | -- | Positive | 246 |
| Enhanced vitamin supplement (riboflavin, vitamins B6, B12, D, myo-inositol, probiotics, zinc + stand | -- | Positive | 1729 |
Thời điểm dùng tốt nhất: With or without food; consistent daily timing preferred
Safety & Side Effects
Tác dụng phụ đã được báo cáo
- ⚠ Generally very well-tolerated
- ⚠ May mask vitamin B12 deficiency at high doses
- ⚠ Rare: mild gastrointestinal discomfort
Tương tác đã biết
- ● Methotrexate (folate may reduce efficacy)
- ● Antiepileptic drugs (phenytoin, carbamazepine — mutual interference)
- ● Vitamin B12 (co-supplementation recommended for homocysteine reduction)
Mức hấp thụ tối đa cho phép: 1,000 mcg/day folic acid from supplements
Luôn tham khảo ý kiến bác sĩ trước khi bắt đầu sử dụng bất kỳ thực phẩm bổ sung nào.Luôn tham khảo ý kiến chuyên gia y tế trước khi sử dụng bất kỳ thực phẩm chức năng nào.
Frequently Asked Questions
Does Folate (Vitamin B9) help with Elevated Homocysteine (Hyperhomocysteinemia)?
Based on 30 studies with 30,000 participants, there is moderate evidence from clinical studies that Folate (Vitamin B9) may support Elevated Homocysteine (Hyperhomocysteinemia) management. Our evidence grade is B (Good Evidence).
How much Folate (Vitamin B9) should I take for Elevated Homocysteine (Hyperhomocysteinemia)?
Studies have used various dosages. A commonly studied range is 400 mcg DFE/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Folate (Vitamin B9)?
Reported side effects may include Generally very well-tolerated, May mask vitamin B12 deficiency at high doses, Rare: mild gastrointestinal discomfort. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Folate (Vitamin B9) and Elevated Homocysteine (Hyperhomocysteinemia)?
We rate the evidence as Grade B (Good Evidence). This rating is based on 30 peer-reviewed studies with 30,000 total participants. The overall direction of effect is positive.
Related Evidence
Folate (Vitamin B9) cho các tình trạng khác
References
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