Folate (Vitamin B9) для Coronary Artery Disease (CAD)

Q: Does Folate (Vitamin B9) help with Coronary Artery Disease (CAD)?

Based on 10 studies with 40,000 participants, there is limited but promising evidence that Folate (Vitamin B9) may support Coronary Artery Disease (CAD) management. Our evidence grade is C (Some Evidence).

Q: How much Folate (Vitamin B9) should I take for Coronary Artery Disease (CAD)?

Studies have used various dosages. A commonly studied range is 400 mcg DFE/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Folate (Vitamin B9)?

Reported side effects may include Generally very well-tolerated, May mask vitamin B12 deficiency at high doses, Rare: mild gastrointestinal discomfort. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Folate (Vitamin B9) and Coronary Artery Disease (CAD)?

We rate the evidence as Grade C (Some Evidence). This rating is based on 10 peer-reviewed studies with 40,000 total participants. The overall direction of effect is mixed.

C Доказательства Доказательства ограничены небольшими исследованиями, однако имеются некоторые положительные сигналы.

CSPPT showed stroke benefit but not MI benefit. HOPE-2 was negative for cardiovascular events despite homocysteine reduction. Research suggests benefit may be limited to populations without folic acid fortification.

𝕏 LinkedIn

<\/script>\n

`; }, get iframeSnippet() { const domain = 'heartcited.com'; const params = 'ingredient\u003Dfolate\u0026condition\u003Dcoronary\u002Dartery\u002Ddisease'; return ``; }, get activeSnippet() { return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet; }, copySnippet() { navigator.clipboard.writeText(this.activeSnippet).then(() => { this.copied = true; setTimeout(() => { this.copied = false; }, 2000); }); } }" @keydown.escape.window="open = false" @click.outside="open = false">

Embed This Widget

Style

Widget powered by . Free, no account required.

Итог

Key Study Findings

cross-sectional n=800

Excessive Daytime Sleepiness is Associated With Malnutrition, Dysphagia, and Vitamin D Deficiency in Older Adults.

Dose: None или: Placebo Эффект: OR 1.73 (malnutrition), OR 2.01 (dysphagia), OR 2.0 (vitamin D deficiency) <0.05

Meta-Analysis n=129

Effects of Nutritional Supplements and Dietary Interventions on Cardiovascular Outcomes: An Umbrella Review and Evidence …

Dose: None или: None Outcome: Mortality Эффект: None None

Популяция: None

Review

Folic acid and diseases - supplement it or not?

Dose: None или: Placebo Эффект: None None

Review

Prevention of strokes.

Dose: Antiplatelet, antihypertensives, statins или: None Outcome: Stroke prevention Эффект: None None

Популяция: Stroke-risk population

Key Statistics

Исследования

40000

Участники

↔

Mixed

Оценка

Referenced Papers

Excessive Daytime Sleepiness is Associated With Malnutrition, Dysphagia, and Vitamin D Deficiency in Older Adults. Other

Journal of the … 2021 22 цитирований

Effects of Nutritional Supplements and Dietary Interventions on Cardiovascular Outcomes: An Umbrella Review and Evidence Map. Meta-Analysis

Annals of internal … 2019 133 цитирований

Folic acid and diseases - supplement it or not? Review

Revista da Associacao … 2016 62 цитирований

Prevention of strokes. Review

Current atherosclerosis reports 2001 2 цитирований

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Часто используемые дозировки

general:: 400 mcg DFE/day
homocysteinereduction:: 400-800 mcg/day folic acid (with B12 and B6)

Верхний предел: 1,000 mcg/day folic acid from supplements

Дозировки, изученные в исследованиях

Дозировка	Длительность	Эффект	N
None	--	Positive	800
None	--	Neutral	129
None	--	Mixed	--
Antiplatelet, antihypertensives, statins	--	Positive	--

Лучшее время приёма: With or without food; consistent daily timing preferred

Safety & Side Effects

Зарегистрированные побочные эффекты

⚠ Generally very well-tolerated
⚠ May mask vitamin B12 deficiency at high doses
⚠ Rare: mild gastrointestinal discomfort

Известные взаимодействия

● Methotrexate (folate may reduce efficacy)
● Antiepileptic drugs (phenytoin, carbamazepine — mutual interference)
● Vitamin B12 (co-supplementation recommended for homocysteine reduction)

Допустимый верхний уровень потребления: 1,000 mcg/day folic acid from supplements

Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.

Frequently Asked Questions

Does Folate (Vitamin B9) help with Coronary Artery Disease (CAD)?

Based on 10 studies with 40,000 participants, there is limited but promising evidence that Folate (Vitamin B9) may support Coronary Artery Disease (CAD) management. Our evidence grade is C (Some Evidence).

How much Folate (Vitamin B9) should I take for Coronary Artery Disease (CAD)?

Studies have used various dosages. A commonly studied range is 400 mcg DFE/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Folate (Vitamin B9)?

Reported side effects may include Generally very well-tolerated, May mask vitamin B12 deficiency at high doses, Rare: mild gastrointestinal discomfort. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Folate (Vitamin B9) and Coronary Artery Disease (CAD)?

We rate the evidence as Grade C (Some Evidence). This rating is based on 10 peer-reviewed studies with 40,000 total participants. The overall direction of effect is mixed.

Другие ингредиенты для Coronary Artery Disease (CAD)

Omega-3 Fatty Acids (EPA/DHA) B Magnesium C Selenium C

Folate (Vitamin B9) для других состояний

Elevated Homocysteine (Hyperhomocysteinemia) B

Краткий вывод

Evidence Strength52%

Moderate confidence

Разбор исследований

RCT (0)Meta (1)Other (9)

Сравнить альтернативы

Узнайте, как другие ингредиенты сравниваются при данном состоянии.

Посмотреть все ингредиенты для Coronary Artery Disease (CAD)

Узнать больше

References

[1] Saadet Koc Okudur et al.. J Am Med Dir Assoc. 2021. Excessive Daytime Sleepiness is Associated With Malnutrition, Dysphagia, and Vitamin D Deficiency in Older Adults. doi:10.1016/j.jamda.2021.05.035 PubMed
[2] Safi U Khan et al.. Ann Intern Med. 2019. Effects of Nutritional Supplements and Dietary Interventions on Cardiovascular Outcomes: An Umbrella Review and Evidence Map. doi:10.7326/M19-0341 PubMed
[3] Siaw-Cheok Liew. Rev Assoc Med Bras (1992). 2016. Folic acid and diseases - supplement it or not? doi:10.1590/1806-9282.62.01.90 PubMed
[4] T J Jeerakathil et al.. Curr Atheroscler Rep. 2001. Prevention of strokes. doi:10.1007/s11883-001-0026-7 PubMed

Отказ от ответственности FDA: Данные утверждения не были оценены Управлением по санитарному надзору за качеством пищевых продуктов и медикаментов (FDA). Продукты и информация на этом сайте не предназначены для диагностики, лечения, излечения или профилактики каких-либо заболеваний. Представленные оценки доказательности основаны на нашем анализе опубликованных рецензируемых исследований и не являются медицинской консультацией. Всегда консультируйтесь с лечащим врачом перед началом приёма любых добавок.