Folate (Vitamin B9) لـ Coronary Artery Disease (CAD)

Q: Does Folate (Vitamin B9) help with Coronary Artery Disease (CAD)?

Based on 10 studies with 40,000 participants, there is limited but promising evidence that Folate (Vitamin B9) may support Coronary Artery Disease (CAD) management. Our evidence grade is C (Some Evidence).

Q: How much Folate (Vitamin B9) should I take for Coronary Artery Disease (CAD)?

Studies have used various dosages. A commonly studied range is 400 mcg DFE/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Folate (Vitamin B9)?

Reported side effects may include Generally very well-tolerated, May mask vitamin B12 deficiency at high doses, Rare: mild gastrointestinal discomfort. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Folate (Vitamin B9) and Coronary Artery Disease (CAD)?

We rate the evidence as Grade C (Some Evidence). This rating is based on 10 peer-reviewed studies with 40,000 total participants. The overall direction of effect is mixed.

C الأدلة أدلة محدودة من دراسات صغيرة، غير أن ثمة بعض الإشارات الإيجابية.

CSPPT showed stroke benefit but not MI benefit. HOPE-2 was negative for cardiovascular events despite homocysteine reduction. Research suggests benefit may be limited to populations without folic acid fortification.

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الخلاصة

Key Study Findings

cross-sectional n=800

Excessive Daytime Sleepiness is Associated With Malnutrition, Dysphagia, and Vitamin D Deficiency in Older Adults.

Dose: None مقابل: Placebo التأثير: OR 1.73 (malnutrition), OR 2.01 (dysphagia), OR 2.0 (vitamin D deficiency) <0.05

Meta-Analysis n=129

Effects of Nutritional Supplements and Dietary Interventions on Cardiovascular Outcomes: An Umbrella Review and Evidence …

Dose: None مقابل: None Outcome: Mortality التأثير: None None

المجتمع المدروس: None

Review

Folic acid and diseases - supplement it or not?

Dose: None مقابل: Placebo التأثير: None None

Review

Prevention of strokes.

Dose: Antiplatelet, antihypertensives, statins مقابل: None Outcome: Stroke prevention التأثير: None None

المجتمع المدروس: Stroke-risk population

Key Statistics

الدراسات

40000

المشاركون

↔

Mixed

التقييم

Referenced Papers

Excessive Daytime Sleepiness is Associated With Malnutrition, Dysphagia, and Vitamin D Deficiency in Older Adults. Other

Journal of the … 2021 22 اقتباسات

Effects of Nutritional Supplements and Dietary Interventions on Cardiovascular Outcomes: An Umbrella Review and Evidence Map. Meta-Analysis

Annals of internal … 2019 133 اقتباسات

Folic acid and diseases - supplement it or not? Review

Revista da Associacao … 2016 62 اقتباسات

Prevention of strokes. Review

Current atherosclerosis reports 2001 2 اقتباسات

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

الجرعات الشائعة

general:: 400 mcg DFE/day
homocysteinereduction:: 400-800 mcg/day folic acid (with B12 and B6)

الحد الأعلى: 1,000 mcg/day folic acid from supplements

الجرعات المدروسة في الأبحاث

الجرعة	المدة	التأثير	ن
None	--	Positive	800
None	--	Neutral	129
None	--	Mixed	--
Antiplatelet, antihypertensives, statins	--	Positive	--

أفضل وقت للتناول: With or without food; consistent daily timing preferred

Safety & Side Effects

الآثار الجانبية المُبلّغ عنها

⚠ Generally very well-tolerated
⚠ May mask vitamin B12 deficiency at high doses
⚠ Rare: mild gastrointestinal discomfort

التفاعلات المعروفة

● Methotrexate (folate may reduce efficacy)
● Antiepileptic drugs (phenytoin, carbamazepine — mutual interference)
● Vitamin B12 (co-supplementation recommended for homocysteine reduction)

الحد الأقصى المسموح به: 1,000 mcg/day folic acid from supplements

استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.

Frequently Asked Questions

Does Folate (Vitamin B9) help with Coronary Artery Disease (CAD)?

Based on 10 studies with 40,000 participants, there is limited but promising evidence that Folate (Vitamin B9) may support Coronary Artery Disease (CAD) management. Our evidence grade is C (Some Evidence).

How much Folate (Vitamin B9) should I take for Coronary Artery Disease (CAD)?

Studies have used various dosages. A commonly studied range is 400 mcg DFE/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Folate (Vitamin B9)?

Reported side effects may include Generally very well-tolerated, May mask vitamin B12 deficiency at high doses, Rare: mild gastrointestinal discomfort. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Folate (Vitamin B9) and Coronary Artery Disease (CAD)?

We rate the evidence as Grade C (Some Evidence). This rating is based on 10 peer-reviewed studies with 40,000 total participants. The overall direction of effect is mixed.

مكونات أخرى لـ Coronary Artery Disease (CAD)

Omega-3 Fatty Acids (EPA/DHA) B Magnesium C Selenium C

Folate (Vitamin B9) لحالات أخرى

Elevated Homocysteine (Hyperhomocysteinemia) B

الخلاصة السريعة

Evidence Strength52%

Moderate confidence

تفصيل الدراسات

RCT (0)Meta (1)Other (9)

قارن البدائل

اعرف كيف تقارن المكونات الأخرى لهذه الحالة.

عرض جميع المكونات لـ Coronary Artery Disease (CAD)

اعرف المزيد

References

[1] Saadet Koc Okudur et al.. J Am Med Dir Assoc. 2021. Excessive Daytime Sleepiness is Associated With Malnutrition, Dysphagia, and Vitamin D Deficiency in Older Adults. doi:10.1016/j.jamda.2021.05.035 PubMed
[2] Safi U Khan et al.. Ann Intern Med. 2019. Effects of Nutritional Supplements and Dietary Interventions on Cardiovascular Outcomes: An Umbrella Review and Evidence Map. doi:10.7326/M19-0341 PubMed
[3] Siaw-Cheok Liew. Rev Assoc Med Bras (1992). 2016. Folic acid and diseases - supplement it or not? doi:10.1590/1806-9282.62.01.90 PubMed
[4] T J Jeerakathil et al.. Curr Atheroscler Rep. 2001. Prevention of strokes. doi:10.1007/s11883-001-0026-7 PubMed

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