المكونات

Direct substrate for endothelial nitric oxide synthase (eNOS), which produces nitric oxide (NO) — the primary endogenous vasodilator; NO activates …

Converted to L-arginine in the kidneys bypassing hepatic first-pass metabolism, maintaining sustained plasma arginine levels; this recycling pathway maintains nitric …

Stabilizes cardiac cell membranes by modulating calcium and potassium channel activity providing anti-arrhythmic effects; acts as an osmolyte maintaining cardiomyocyte …

A serine protease that directly degrades fibrin through fibrinolytic activity and enhancement of endogenous t-PA while inhibiting PAI-1; reduces blood …

Inhibits LDL oxidation and foam cell formation; reduces blood pressure through direct vasorelaxation via endothelium-dependent nitric oxide release; inhibits ACE …

A xanthophyll carotenoid with antioxidant potency 6,000x greater than vitamin C; spans the entire cell membrane bilayer providing protection against …

Rich source of oligomeric proanthocyanidins (OPCs) that inhibit LDL oxidation with potency exceeding vitamins C and E; enhances endothelial nitric …

Activates SIRT1 and AMPK pathways enhancing mitochondrial biogenesis; potent inhibitor of LDL oxidation and foam cell formation; enhances endothelial nitric …

The most efficient singlet oxygen quencher among dietary carotenoids; accumulates in LDL particles where it inhibits oxidation more effectively than …

Redox cofactor that stimulates mitochondrial biogenesis through PGC-1alpha/SIRT1/AMPK signaling pathways; acts as an exceptionally potent antioxidant protecting mitochondrial membranes and …

Essential cofactor in mitochondrial electron transport chain (Complex I-III) supporting cellular energy production (ATP) in high-demand cardiac tissue; potent lipid-soluble …

Direct precursor to NAD+ (nicotinamide adenine dinucleotide), a critical coenzyme for mitochondrial energy metabolism, sirtuin-mediated DNA repair, and PARP-mediated stress …

Long-chain polyunsaturated fatty acids that incorporate into cell membranes modulating inflammatory signaling via reduced arachidonic acid conversion to pro-inflammatory eicosanoids; …

Delivers EPA/DHA in phospholipid-bound form which may enhance bioavailability and cellular uptake; contains naturally occurring astaxanthin providing additional antioxidant protection …

A monounsaturated fatty acid that acts as a lipokine signaling between adipose tissue and other organs; supports healthy lipid metabolism …

Rich source of alpha-linolenic acid (ALA), a plant-based omega-3 partially converted to EPA (5-10%) and DHA (<5%); lignans in ground …

Soluble gel-forming fiber that binds bile acids in the intestinal lumen, forcing the liver to use circulating cholesterol to synthesize …

A positively charged polysaccharide that electrostatically binds negatively charged bile acids and dietary fat forming insoluble complexes excreted in feces; …

Soluble beta-1,3/1,4-glucan fiber forms a viscous gel trapping bile acids and cholesterol, reducing intestinal absorption; increases bile acid excretion forcing …

Structural analogs of cholesterol that compete for incorporation into intestinal mixed micelles, reducing dietary and biliary cholesterol absorption by 30-50%; …

Contains monacolin K — chemically identical to lovastatin — which inhibits HMG-CoA reductase, the rate-limiting enzyme in hepatic cholesterol synthesis; …

Oligomeric procyanidins and flavonoids inhibit phosphodiesterase-3 (PDE3) increasing cardiac cAMP and improving contractile force (positive inotropic effect without increasing oxygen …

Allicin and S-allylcysteine (SAC) in aged garlic extract inhibit HMG-CoA reductase and cholesterol synthesis; enhance hydrogen sulfide (H2S) production promoting …

Potent modulator of vascular inflammation through NF-kB, JAK/STAT, and MAPK pathway inhibition; reduces endothelial expression of adhesion molecules decreasing monocyte …

Activates AMPK in hepatocytes, adipocytes, and skeletal muscle; upregulates LDL receptor expression by stabilizing LDLR mRNA via PCSK9 inhibition, increasing …

Essential cofactor for >300 enzymatic reactions regulating vascular tone; acts as a natural calcium channel blocker relaxing vascular smooth muscle; …

Essential for cardiac muscle contraction-relaxation cycling through calcium-induced calcium release from the sarcoplasmic reticulum; maintains normal heart rhythm; low dietary …

Primary intracellular cation essential for cardiac rhythm; promotes sodium excretion by inhibiting renal sodium reabsorption, directly counteracting sodium's hypertensive effect; …

Essential component of selenoprotein P and glutathione peroxidases (GPx) — the primary enzymatic antioxidant defense against lipid peroxidation and LDL …

Oleuropein inhibits ACE activity reducing angiotensin II-mediated vasoconstriction; enhances endothelial nitric oxide production; potent antioxidant activity protects LDL from oxidation …

Combination providing both substrate (L-arginine) and sustained precursor (L-citrulline) for endothelial nitric oxide synthase (eNOS); NO activates soluble guanylate cyclase …

Concentrated source of dietary inorganic nitrate converted to nitrite by oral commensal bacteria, then further reduced to nitric oxide in …

(-)-Epicatechin and related procyanidins activate endothelial nitric oxide synthase (eNOS) via PI3K/Akt signaling; sustained NO production improves flow-mediated dilation; inhibit …

Essential cofactor in one-carbon metabolism; converts homocysteine to methionine via methionine synthase (with B12), directly reducing plasma homocysteine levels — …

Primary lipid-soluble antioxidant in LDL particles and cell membranes; inhibits LDL oxidation — a key early step in atherogenesis; modulates …

Binds to vitamin D receptors (VDR) on cardiomyocytes, vascular smooth muscle, and endothelial cells regulating calcium handling and contractile function; …

Activates matrix Gla protein (MGP) — the most potent natural inhibitor of arterial calcification — through gamma-carboxylation; directs calcium deposition …

Activates GPR109A (HCA2) receptor in adipocytes reducing lipolysis and free fatty acid flux to the liver, decreasing hepatic VLDL/triglyceride production; …