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HeartCited

Plant Sterols/Stanols
Plant Sterols/Stanols

fiber

يُعرف أيضاً بـ: Phytosterols, Phytostanols, Beta-Sitosterol, Campesterol, CholestOff

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About





            

                
Plant sterols and stanols are structural analogs of cholesterol that compete for intestinal absorption. A comprehensive meta-analysis of 84 RCTs demonstrated 8-10% LDL reduction at 2g/day. The FDA, EU, and AHA have all approved health claims. Effects are additive to statins, providing an additional 6-10% LDL reduction.

            

        

        

        
        
        

            

  
How It Works





            

                
Structural analogs of cholesterol that compete for incorporation into intestinal mixed micelles, reducing dietary and biliary cholesterol absorption by 30-50%; the liver compensates by upregulating LDL receptors, increasing clearance of circulating LDL; stanols (saturated form) are not absorbed at all, while sterols are minimally absorbed (<5%).

            

        

        

        
        
        

            

  
Evidence For Conditions





            

                

                    

                        
                            

                                الحالة
                                التقييم
                                الدراسات
                                المشاركون
                                
                            

                        
                        
                            
                            

                                
                                    
                                        High Cholesterol (Hyperlipidemia)
                                    
                                
                                
                                    A

                                
                                
                                    84
                                
                                
                                    5000
                                
                                
                                    
                                        عرض →
                                    
                                
                            

                            
                        
                    

                

            

        

        

        
        
        

            

  
Side Effects





            
    
                
                
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                    Generally very well-tolerated
                
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                    May reduce absorption of fat-soluble vitamins (A, D, E, K) and carotenoids
                
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                    Mild gastrointestinal discomfort (rare)
                
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Drug & Supplement Interactions





            
    
                
                
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                    Ezetimibe (may reduce efficacy of both, as both target intestinal cholesterol absorption)
                
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                    Fat-soluble vitamins and carotenoids (may reduce absorption — supplement if needed)
                
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                    Statins (additive LDL reduction — beneficial combination)
                
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                أخبر مقدم الرعاية الصحية دائماً بجميع المكملات التي تتناولها.
            

        

        

        
        
        

            

  
Related Ingredients





            

                
                
                    Psyllium
                    
                
                
                
                    Beta-Glucan
                    
                
                
                
                    Chitosan
                    
                
                
            

        

        
    


    
    












    

        إخلاء مسؤولية FDA:
        لم تُقيَّم هذه البيانات من قبل إدارة الغذاء والدواء (FDA). لا تهدف المنتجات والمعلومات الواردة في هذا الموقع إلى تشخيص أو علاج أو شفاء أو الوقاية من أي مرض. تستند تقييمات الأدلة المعروضة إلى تحليلنا للأبحاث المحكّمة المنشورة ولا تُشكّل نصيحة طبية. استشر مقدم الرعاية الصحية دائماً قبل البدء بأي نظام مكملات.