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HeartCited

Plant Sterols/Stanols
Plant Sterols/Stanols

fiber

别名: Phytosterols, Phytostanols, Beta-Sitosterol, Campesterol, CholestOff

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About





            

                
Plant sterols and stanols are structural analogs of cholesterol that compete for intestinal absorption. A comprehensive meta-analysis of 84 RCTs demonstrated 8-10% LDL reduction at 2g/day. The FDA, EU, and AHA have all approved health claims. Effects are additive to statins, providing an additional 6-10% LDL reduction.

            

        

        

        
        
        

            

  
How It Works





            

                
Structural analogs of cholesterol that compete for incorporation into intestinal mixed micelles, reducing dietary and biliary cholesterol absorption by 30-50%; the liver compensates by upregulating LDL receptors, increasing clearance of circulating LDL; stanols (saturated form) are not absorbed at all, while sterols are minimally absorbed (<5%).

            

        

        

        
        
        

            

  
Evidence For Conditions





            

                

                    

                        
                            

                                健康状况
                                等级
                                研究数量
                                受试者
                                
                            

                        
                        
                            
                            

                                
                                    
                                        High Cholesterol (Hyperlipidemia)
                                    
                                
                                
                                    A

                                
                                
                                    84
                                
                                
                                    5000
                                
                                
                                    
                                        查看 →
                                    
                                
                            

                            
                        
                    

                

            

        

        

        
        
        

            

  
Side Effects





            
    
                
                
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                    Generally very well-tolerated
                
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                    May reduce absorption of fat-soluble vitamins (A, D, E, K) and carotenoids
                
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                    Mild gastrointestinal discomfort (rare)
                
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Drug & Supplement Interactions





            
    
                
                
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                    Ezetimibe (may reduce efficacy of both, as both target intestinal cholesterol absorption)
                
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                    Fat-soluble vitamins and carotenoids (may reduce absorption — supplement if needed)
                
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                    Statins (additive LDL reduction — beneficial combination)
                
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                请务必告知您的医疗保健提供者您正在服用的所有补充剂。
            

        

        

        
        
        

            

  
Related Ingredients





            

                
                
                    Psyllium
                    
                
                
                
                    Beta-Glucan
                    
                
                
                
                    Chitosan
                    
                
                
            

        

        
    


    
    












    

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