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Folate (Vitamin B9) per Coronary Artery Disease (CAD)

C

CSPPT showed stroke benefit but not MI benefit. HOPE-2 was negative for cardiovascular events despite homocysteine reduction. Research suggests benefit may be limited to populations without folic acid fortification.

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            C

        

        

            
In sintesi

            
            
CSPPT showed stroke benefit but not MI benefit. HOPE-2 was negative for cardiovascular events despite homocysteine reduction. Research suggests benefit may be limited to populations without folic acid fortification.

            
            
        

    











    
    

        
        

            

  
Key Statistics





            


    

        
10

        
Studi

    

    

        
40000

        
Partecipanti

    

    

        
            
            ↔
            
        
        
Mixed

    

    

        C

        
Grado

    




        


        
        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Dosaggi di uso comune

                

                    
                    

                        
general:

                        
400 mcg DFE/day

                    

                    
                    

                        
homocysteinereduction:

                        
400-800 mcg/day folic acid (with B12 and B6)

                    

                    
                

                
                

                    Limite massimo: 1,000 mcg/day folic acid from supplements
                

                
            

            

            

            
            

                Momento migliore per l'assunzione: With or without food; consistent daily timing preferred
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Effetti collaterali segnalati

                    
    
                        
                        
  • 
                            ⚠
                            Generally very well-tolerated
                        
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                            ⚠
                            May mask vitamin B12 deficiency at high doses
                        
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                            ⚠
                            Rare: mild gastrointestinal discomfort
                        
    • 
                        
                    

                

                

                
                

                    
Interazioni note

                    
    
                        
                        
  • 
                            ●
                            Methotrexate (folate may reduce efficacy)
                        
    • 
                        
                        
  • 
                            ●
                            Antiepileptic drugs (phenytoin, carbamazepine — mutual interference)
                        
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  • 
                            ●
                            Vitamin B12 (co-supplementation recommended for homocysteine reduction)
                        
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                        Livello di assunzione massimo tollerabile: 1,000 mcg/day folic acid from supplements
                    

                

                
            

            

                Consultare sempre il proprio medico prima di iniziare qualsiasi integratore.Consultate sempre il vostro medico prima di iniziare qualsiasi integratore.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Folate (Vitamin B9) help with Coronary Artery Disease (CAD)?
            
        
        

            Based on 10 studies with 40,000 participants, there is limited but promising evidence that Folate (Vitamin B9) may support Coronary Artery Disease (CAD) management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much Folate (Vitamin B9) should I take for Coronary Artery Disease (CAD)?
            
        
        

            Studies have used various dosages. A commonly studied range is 400 mcg DFE/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Folate (Vitamin B9)?
            
        
        

            Reported side effects may include Generally very well-tolerated, May mask vitamin B12 deficiency at high doses, Rare: mild gastrointestinal discomfort. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Folate (Vitamin B9) and Coronary Artery Disease (CAD)?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 10 peer-reviewed studies with 40,000 total participants. The overall direction of effect is mixed.
        

    

    




        

        

        
        
        

            

  
Related Evidence





            

                
                

                    
Altri ingredienti per Coronary Artery Disease (CAD)

                    

                        
                        
                            Omega-3 Fatty Acids (EPA/DHA)
                            B

                        
                        
                        
                            Magnesium
                            C

                        
                        
                        
                            Selenium
                            C

                        
                        
                    

                

                

                
                

                    
Folate (Vitamin B9) per altre condizioni

                    

                        
                        
                            Elevated Homocysteine (Hyperhomocysteinemia)
                            B

                        
                        
                    

                

                
            

        

        

    


    
    












    

        Avvertenza FDA:
        Queste affermazioni non sono state valutate dalla Food and Drug Administration. I prodotti e le informazioni presenti su questo sito web non sono destinati a diagnosticare, trattare, curare o prevenire alcuna malattia. I gradi di evidenza presentati si basano sulla nostra analisi della ricerca pubblicata e sottoposta a revisione paritaria e non costituiscono consulenza medica. Consultate sempre il vostro medico prima di iniziare qualsiasi regime di integrazione.