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Omega-3 Fatty Acids (EPA/DHA) 用于 冠状动脉疾病（CAD）

B

REDUCE-IT: 25% MACE reduction with high-dose EPA. Mixed results at lower doses (VITAL, ASCEND). Most beneficial in those with elevated triglycerides. AHA recommends for secondary prevention.

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            B

        

        

            
结论

            
            
REDUCE-IT: 25% MACE reduction with high-dose EPA. Mixed results at lower doses (VITAL, ASCEND). Most beneficial in those with elevated triglycerides. AHA recommends for secondary prevention.

            
            
        

    











    
    

        
        

            

  
Key Statistics





            


    

        
20

        
研究数量

    

    

        
50000

        
受试者

    

    

        
            
            ↑
            
        
        
Positive

    

    

        B

        
等级

    




        


        
        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
常用剂量

                

                    
                    

                        
general:

                        
1,000 mg combined EPA/DHA per day

                    

                    
                    

                        
triglyceridereduction:

                        
2,000-4,000 mg/day (prescription-grade)

                    

                    
                

                
                

                    上限： 5,000 mg/day combined EPA/DHA (FDA GRAS up to 3,000 mg/day from supplements)
                

                
            

            

            

            
            

                最佳服用时间： With meals containing fat for optimal absorption; divide doses >2,000 mg
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
已报告的副作用

                    
    
                        
                        
  • 
                            ⚠
                            Fishy aftertaste or burping
                        
    • 
                        
                        
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                            ⚠
                            Mild gastrointestinal discomfort
                        
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                            ⚠
                            Potential increased bleeding time at very high doses
                        
    • 
                        
                        
  • 
                            ⚠
                            May increase atrial fibrillation risk at doses >2g/day
                        
    • 
                        
                    

                

                

                
                

                    
已知相互作用

                    
    
                        
                        
  • 
                            ●
                            Anticoagulants and antiplatelet drugs (may increase bleeding risk at high doses)
                        
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                            ●
                            Blood pressure medications (additive hypotensive effect)
                        
    • 
                        
                        
  • 
                            ●
                            Orlistat (may reduce omega-3 absorption)
                        
    • 
                        
                    

                

                

                
                

                    

                        可耐受最高摄入量： 5,000 mg/day combined EPA/DHA (FDA GRAS up to 3,000 mg/day from supplements)
                    

                

                
            

            

                在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Omega-3 Fatty Acids (EPA/DHA) help with 冠状动脉疾病（CAD）?
            
        
        

            Based on 20 studies with 50,000 participants, there is moderate evidence from clinical studies that Omega-3 Fatty Acids (EPA/DHA) may support 冠状动脉疾病（CAD） management. Our evidence grade is B (Good Evidence).
        

    

    
    

        
            How much Omega-3 Fatty Acids (EPA/DHA) should I take for 冠状动脉疾病（CAD）?
            
        
        

            Studies have used various dosages. A commonly studied range is 1,000 mg combined EPA/DHA per day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Omega-3 Fatty Acids (EPA/DHA)?
            
        
        

            Reported side effects may include Fishy aftertaste or burping, Mild gastrointestinal discomfort, Potential increased bleeding time at very high doses, May increase atrial fibrillation risk at doses >2g/day. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Omega-3 Fatty Acids (EPA/DHA) and 冠状动脉疾病（CAD）?
            
        
        

            We rate the evidence as Grade B (Good Evidence). This rating is based on 20 peer-reviewed studies with 50,000 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  
Related Evidence





            

                
                

                    
其他成分用于 冠状动脉疾病（CAD）

                    

                        
                        
                            Folate (Vitamin B9)
                            C

                        
                        
                        
                            Magnesium
                            C

                        
                        
                        
                            Selenium
                            C

                        
                        
                    

                

                

                
                

                    
Omega-3 Fatty Acids (EPA/DHA) 用于其他健康状况

                    

                        
                        
                            高甘油三酯血症
                            A

                        
                        
                        
                            心律失常
                            B

                        
                        
                    

                

                
            

        

        

    


    
    












    

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