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Resveratrol 用于 Atherosclerosis

C

Improves FMD and reduces inflammatory markers. RESVACE trial was negative for cardiac function in heart failure. Bioavailability challenges limit clinical translation.

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            C

        

        

            
结论

            
            
Improves FMD and reduces inflammatory markers. RESVACE trial was negative for cardiac function in heart failure. Bioavailability challenges limit clinical translation.

            
            
        

    











    
    

        
        

            

  
Key Statistics





            


    

        
5

        
研究数量

    

    

        
400

        
受试者

    

    

        
            
            ↑
            
        
        
Positive

    

    

        C

        
等级

    




        


        
        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
常用剂量

                

                    
                    

                        
general:

                        
150-500 mg/day

                    

                    
                    

                        
cardiovascularsupport:

                        
250-500 mg/day trans-resveratrol

                    

                    
                

                
                

                    上限： Not formally established; GI discomfort common above 1,000 mg/day
                

                
            

            

            

            
            

                最佳服用时间： With meals; bioavailability enhanced by piperine co-supplementation
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
已报告的副作用

                    
    
                        
                        
  • 
                            ⚠
                            Gastrointestinal discomfort (nausea, diarrhea, cramping) at high doses
                        
    • 
                        
                        
  • 
                            ⚠
                            Headache
                        
    • 
                        
                        
  • 
                            ⚠
                            May have estrogenic activity at high doses
                        
    • 
                        
                    

                

                

                
                

                    
已知相互作用

                    
    
                        
                        
  • 
                            ●
                            Anticoagulants (may inhibit platelet aggregation)
                        
    • 
                        
                        
  • 
                            ●
                            CYP450 substrates (may inhibit CYP1A2, CYP3A4, CYP2D6)
                        
    • 
                        
                        
  • 
                            ●
                            Blood pressure medications (additive hypotensive effect)
                        
    • 
                        
                        
  • 
                            ●
                            Estrogen-sensitive conditions (weak estrogenic activity)
                        
    • 
                        
                    

                

                

                
                

                    

                        可耐受最高摄入量： Not formally established; GI discomfort common above 1,000 mg/day
                    

                

                
            

            

                在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Resveratrol help with Atherosclerosis?
            
        
        

            Based on 5 studies with 400 participants, there is limited but promising evidence that Resveratrol may support Atherosclerosis management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much Resveratrol should I take for Atherosclerosis?
            
        
        

            Studies have used various dosages. A commonly studied range is 150-500 mg/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Resveratrol?
            
        
        

            Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea, cramping) at high doses, Headache, May have estrogenic activity at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Resveratrol and Atherosclerosis?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 5 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  
Related Evidence





            

                
                
                

                
                

                    
Resveratrol 用于其他健康状况

                    

                        
                        
                            High Blood Pressure (Hypertension)
                            B

                        
                        
                    

                

                
            

        

        

    


    
    












    

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