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Resveratrol
Resveratrol

antioxidant

别名: trans-Resveratrol, 3,5,4'-Trihydroxystilbene, Red Wine Polyphenol

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About





            

                
Resveratrol is a polyphenolic stilbene that activates SIRT1 and AMPK pathways, enhances endothelial nitric oxide production, and inhibits LDL oxidation. A 2015 meta-analysis of 10 RCTs found resveratrol at >=150 mg/day reduced systolic blood pressure by 11.9 mmHg in hypertensive patients. Bioavailability remains a challenge due to rapid hepatic metabolism.

            

        

        

        
        
        

            

  
How It Works





            

                
Activates SIRT1 and AMPK pathways enhancing mitochondrial biogenesis; potent inhibitor of LDL oxidation and foam cell formation; enhances endothelial nitric oxide synthase (eNOS) expression improving vasodilation; inhibits platelet aggregation through COX-1 and thromboxane A2 pathways; anti-inflammatory via NF-kB suppression.

            

        

        

        
        
        

            

  
Evidence For Conditions





            

                

                    

                        
                            

                                健康状况
                                等级
                                研究数量
                                受试者
                                
                            

                        
                        
                            
                            

                                
                                    
                                        High Blood Pressure (Hypertension)
                                    
                                
                                
                                    B

                                
                                
                                    10
                                
                                
                                    600
                                
                                
                                    
                                        查看 →
                                    
                                
                            

                            
                            

                                
                                    
                                        Atherosclerosis
                                    
                                
                                
                                    C

                                
                                
                                    5
                                
                                
                                    400
                                
                                
                                    
                                        查看 →
                                    
                                
                            

                            
                        
                    

                

            

        

        

        
        
        

            

  
Side Effects





            
    
                
                
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                    Gastrointestinal discomfort (nausea, diarrhea, cramping) at high doses
                
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                    Headache
                
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                    May have estrogenic activity at high doses
                
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Drug & Supplement Interactions





            
    
                
                
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                    Anticoagulants (may inhibit platelet aggregation)
                
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                    CYP450 substrates (may inhibit CYP1A2, CYP3A4, CYP2D6)
                
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                    Blood pressure medications (additive hypotensive effect)
                
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                    Estrogen-sensitive conditions (weak estrogenic activity)
                
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Related Ingredients





            

                
                
                    Grape Seed Extract
                    
                
                
                
                    Astaxanthin
                    
                
                
                
                    Quercetin
                    
                
                
                
                    Lycopene
                    
                
                
            

        

        
    


    
    












    

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