QuercetinQuercetin
antioxidant
别名: Quercetin Dihydrate, Quercetin Phytosome, Isoquercetin
About
Quercetin is a ubiquitous dietary flavonoid that reduces blood pressure through endothelium-dependent nitric oxide release and ACE inhibition. A 2020 meta-analysis of 17 RCTs found quercetin at >=500 mg/day reduced systolic blood pressure by 3.09 mmHg and diastolic by 2.86 mmHg, with greater effects in hypertensive subjects.
How It Works
Inhibits LDL oxidation and foam cell formation; reduces blood pressure through direct vasorelaxation via endothelium-dependent nitric oxide release; inhibits ACE activity; anti-inflammatory via NF-kB, COX-2, and lipoxygenase inhibition; reduces platelet aggregation; may inhibit PCSK9 expression reducing LDL receptor degradation.
Evidence For Conditions
| 健康状况 | 等级 | 研究数量 | 受试者 | |
|---|---|---|---|---|
| High Blood Pressure (Hypertension) | B | 17 | 900 | 查看 → |
| Atherosclerosis | D | 2 | 100 | 查看 → |
Side Effects
- Generally well-tolerated
- Headache (rare)
- Mild gastrointestinal discomfort
- Tingling in extremities (rare, high doses)
Drug & Supplement Interactions
- Antibiotics (quinolones — may reduce efficacy)
- Cyclosporine (may increase blood levels)
- Anticoagulants (may have mild antiplatelet effect)
- Blood pressure medications (additive effect)
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Related Ingredients
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