Lycopene 用于 动脉粥样硬化
D 研究 目前仅存在初步研究（实验室研究、病例报告）。EURAMIC study showed association between adipose lycopene and lower MI risk. Cambridge study improved FMD in CAD patients. Interventional evidence is limited.
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D
结论
EURAMIC study showed association between adipose lycopene and lower MI risk. Cambridge study improved FMD in CAD patients. Interventional evidence is limited.
Key Study Findings
Other
Functional food lycopene mitigates obesity-related cognitive decline via lipid metabolism regulation and neuroprotection via taurine …
Dose: 50 mg/kg lycopene in mice
vs: HFD control mice
Outcome: Cognitive function (Y-maze, MWM, novel object recognition)
效果: None
None
研究人群: HFD-induced obese male C57BL/6 mice
Review
Anti-Inflammatory Actions of Plant-Derived Compounds and Prevention of Chronic Diseases: From Molecular Mechanisms to Applications.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: review of plant-derived anti-inflammatory compounds for chronic disease prevention
Observational Study
n=60
Vascular Roads to a Healthier Brain: Lutein Moderates the Influence of Arterial Stiffness on Cognitive …
Dose: None
vs: None
Outcome: Carotenoid moderation of cfPWV-cognition relationship
效果: Beta=0.53, p=0.04 for lutein moderation
0.02
研究人群: Adults, mean age 38.6, 70% female
Meta-Analysis
Antioxidant Lipid Supplement on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis.
Dose: None
vs: Placebo
Outcome: Blood pressure
效果: None
None
研究人群: None
systematic review
n=90
A systematic review on the impact of nutrition and possible supplementation on the deficiency of …
Dose: None
vs: Placebo
效果: None
None
Randomized Controlled Trial
Carotenoid Supplementation for Alleviating the Symptoms of Alzheimer's Disease.
Dose: None
vs: None
Outcome: Cognitive decline
效果: None
None
研究人群: Alzheimer's disease patients
Key Statistics
3
研究数量
200
受试者
↑
Positive
D
等级
Referenced Papers
International journal of …
2025
32 次引用
Clinical nutrition (Edinburgh, …
2025
1 次引用
The Journal of …
2025
A systematic review on the impact of nutrition and possible supplementation on the deficiency of vitamin complexes, iron, omega-3-fatty acids, …
Systematic Review
Archives of gynecology …
2024
18 次引用
International journal of …
2024
11 次引用
Antioxidant Lipid Supplement on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis.
Meta-Analysis
Nutrients
2024
6 次引用
Journal of sleep …
2014
236 次引用
Current atherosclerosis reports
2009
122 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 6-15 mg/day
- cardiovascularsupport:
- 15-30 mg/day
上限： Not formally established; up to 75 mg/day used in clinical trials
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| 50 mg/kg lycopene in mice | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | 60 |
| None | -- | Neutral | -- |
| None | -- | Negative | 90 |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
最佳服用时间： With meals containing fat (cooking with olive oil enhances absorption 2-3x)
Safety & Side Effects
已报告的副作用
- ⚠ Generally well-tolerated
- ⚠ Lycopenodermia (orange skin discoloration) at very high intake — harmless and reversible
已知相互作用
- ● Blood pressure medications (may have mild additive effect)
- ● Beta-carotene (may compete for absorption)
可耐受最高摄入量： Not formally established; up to 75 mg/day used in clinical trials
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Lycopene help with 动脉粥样硬化?
Based on 3 studies with 200 participants, there is preliminary evidence that needs more research that Lycopene may support 动脉粥样硬化 management. Our evidence grade is D (Very Early Research).
How much Lycopene should I take for 动脉粥样硬化?
Studies have used various dosages. A commonly studied range is 6-15 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Lycopene?
Reported side effects may include Generally well-tolerated, Lycopenodermia (orange skin discoloration) at very high intake — harmless and reversible. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Lycopene and 动脉粥样硬化?
We rate the evidence as Grade D (Very Early Research). This rating is based on 3 peer-reviewed studies with 200 total participants. The overall direction of effect is positive.
Related Evidence
其他成分用于 动脉粥样硬化
Lycopene 用于其他健康状况
References
- [1] Kazuhiko Nakadate et al.. Int J Mol Sci. 2025. Anti-Inflammatory Actions of Plant-Derived Compounds and Prevention of Chronic Diseases: From Molecular Mechanisms to Applications. doi:10.3390/ijms26115206 PubMed
- [2] Yuqing Wu et al.. Clin Nutr. 2025. Functional food lycopene mitigates obesity-related cognitive decline via lipid metabolism regulation and neuroprotection via taurine and glutathione pathway. doi:10.1016/j.clnu.2025.06.005 PubMed
- [3] Shreya Verma et al.. J Nutr. 2025. Vascular Roads to a Healthier Brain: Lutein Moderates the Influence of Arterial Stiffness on Cognitive Function. doi:10.1016/j.tjnut.2025.08.029 PubMed
- [4] Friederike Wylenzek et al.. Arch Gynecol Obstet. 2024. A systematic review on the impact of nutrition and possible supplementation on the deficiency of vitamin complexes, iron, omega-3-fatty acids, … doi:10.1007/s00404-024-07555-6 PubMed
- [5] Jolanta Flieger et al.. Int J Mol Sci. 2024. Carotenoid Supplementation for Alleviating the Symptoms of Alzheimer's Disease. doi:10.3390/ijms25168982 PubMed
- [6] Sitong Wan et al.. Nutrients. 2024. Antioxidant Lipid Supplement on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis. doi:10.3390/nu16142213 PubMed
- [7] Michael A Grandner et al.. J Sleep Res. 2014. Sleep symptoms associated with intake of specific dietary nutrients. doi:10.1111/jsr.12084 PubMed
- [8] Graziano Riccioni. Curr Atheroscler Rep. 2009. Carotenoids and cardiovascular disease. doi:10.1007/s11883-009-0065-z PubMed
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