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Lycopene para Atherosclerosis

D Pesquisa Existem apenas investigaciones preliminares (estudos laboratoriais, relatórios de casos).

EURAMIC study showed association between adipose lycopene and lower MI risk. Cambridge study improved FMD in CAD patients. Interventional evidence is limited.

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Conclusão

            
            
EURAMIC study showed association between adipose lycopene and lower MI risk. Cambridge study improved FMD in CAD patients. Interventional evidence is limited.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Other
                
                
                
                
            

            
                Functional food lycopene mitigates obesity-related cognitive decline via lipid metabolism regulation and neuroprotection via taurine …
            
            

                
                Dose: 50 mg/kg lycopene in mice
                
                
                vs: HFD control mice
                
                
                Outcome: Cognitive function (Y-maze, MWM, novel object recognition)
                
                
                Efeito: None
                
                
                None
                
            

            
            
População: HFD-induced obese male C57BL/6 mice

            
        

        
        

            

                
                    Review
                
                
                
                
            

            
                Anti-Inflammatory Actions of Plant-Derived Compounds and Prevention of Chronic Diseases: From Molecular Mechanisms to Applications.
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: None
                
                
                Efeito: None
                
                
                None
                
            

            
            
População: review of plant-derived anti-inflammatory compounds for chronic disease prevention

            
        

        
        

            

                
                    Observational Study
                
                
                n=60
                
                
                
            

            
                Vascular Roads to a Healthier Brain: Lutein Moderates the Influence of Arterial Stiffness on Cognitive …
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: Carotenoid moderation of cfPWV-cognition relationship
                
                
                Efeito: Beta=0.53, p=0.04 for lutein moderation
                
                
                0.02
                
            

            
            
População: Adults, mean age 38.6, 70% female

            
        

        
        

            

                
                    Meta-Analysis
                
                
                
                
            

            
                Antioxidant Lipid Supplement on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis.
            
            

                
                Dose: None
                
                
                vs: Placebo
                
                
                Outcome: Blood pressure
                
                
                Efeito: None
                
                
                None
                
            

            
            
População: None

            
        

        
        

            

                
                    systematic review
                
                
                n=90
                
                
                
            

            
                A systematic review on the impact of nutrition and possible supplementation on the deficiency of …
            
            

                
                Dose: None
                
                
                vs: Placebo
                
                
                
                Efeito: None
                
                
                None
                
            

            
        

        
        

            

                
                    Randomized Controlled Trial
                
                
                
                
            

            
                Carotenoid Supplementation for Alleviating the Symptoms of Alzheimer's Disease.
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: Cognitive decline
                
                
                Efeito: None
                
                
                None
                
            

            
            
População: Alzheimer's disease patients

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
3

        
Estudos

    

    

        
200

        
Participantes

    

    

        
            
            ↑
            
        
        
Positive

    

    

        D

        
Nota

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Anti-Inflammatory Actions of Plant-Derived Compounds and Prevention of Chronic Diseases: From Molecular Mechanisms to Applications.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        International journal of …
                        2025
                        
                        32 citações
                        
                    

                

                
                

                    

                        
                            Functional food lycopene mitigates obesity-related cognitive decline via lipid metabolism regulation and neuroprotection via taurine and glutathione pathway.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Clinical nutrition (Edinburgh, …
                        2025
                        
                        1 citações
                        
                    

                

                
                

                    

                        
                            Vascular Roads to a Healthier Brain: Lutein Moderates the Influence of Arterial Stiffness on Cognitive Function.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        The Journal of …
                        2025
                        
                    

                

                
                

                    

                        
                            A systematic review on the impact of nutrition and possible supplementation on the deficiency of vitamin complexes, iron, omega-3-fatty acids, …
                        
                        
                            
                                Systematic Review
                            
                            
                            
                        
                    

                    

                        Archives of gynecology …
                        2024
                        
                        18 citações
                        
                    

                

                
                

                    

                        
                            Carotenoid Supplementation for Alleviating the Symptoms of Alzheimer's Disease.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        International journal of …
                        2024
                        
                        11 citações
                        
                    

                

                
                

                    

                        
                            Antioxidant Lipid Supplement on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis.
                        
                        
                            
                                Meta-Analysis
                            
                            
                            
                        
                    

                    

                        Nutrients
                        2024
                        
                        6 citações
                        
                    

                

                
                

                    

                        
                            Sleep symptoms associated with intake of specific dietary nutrients.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Journal of sleep …
                        2014
                        
                        236 citações
                        
                    

                

                
                

                    

                        
                            Carotenoids and cardiovascular disease.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Current atherosclerosis reports
                        2009
                        
                        122 citações
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Dosagens Comumente Utilizadas

                

                    
                    

                        
general:

                        
6-15 mg/day

                    

                    
                    

                        
cardiovascularsupport:

                        
15-30 mg/day

                    

                    
                

                
                

                    Limite superior: Not formally established; up to 75 mg/day used in clinical trials
                

                
            

            

            
            

                
Dosagens Estudadas em Pesquisas

                

                    

                        
                            

                                Dosagem
                                Duração
                                Efeito
                                N
                            

                        
                        
                            
                            

                                50 mg/kg lycopene in mice
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                None
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                None
                                --
                                
                                    
                                    Positive
                                    
                                
                                60
                            

                            
                            

                                None
                                --
                                
                                    
                                    Neutral
                                    
                                
                                --
                            

                            
                            

                                None
                                --
                                
                                    
                                    Negative
                                    
                                
                                90
                            

                            
                            

                                None
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                None
                                --
                                
                                    
                                    Mixed
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                Melhor horário: With meals containing fat (cooking with olive oil enhances absorption 2-3x)
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Efeitos Colaterais Relatados

                    
    
                        
                        
  • 
                            ⚠
                            Generally well-tolerated
                        
    • 
                        
                        
  • 
                            ⚠
                            Lycopenodermia (orange skin discoloration) at very high intake — harmless and reversible
                        
    • 
                        
                    

                

                

                
                

                    
Interações Conhecidas

                    
    
                        
                        
  • 
                            ●
                            Blood pressure medications (may have mild additive effect)
                        
    • 
                        
                        
  • 
                            ●
                            Beta-carotene (may compete for absorption)
                        
    • 
                        
                    

                

                

                
                

                    

                        Ingestão máxima tolerável: Not formally established; up to 75 mg/day used in clinical trials
                    

                

                
            

            

                Consulte sempre o seu profissional de saúde antes de iniciar qualquer suplemento.Sempre consulte seu profissional de saúde antes de iniciar qualquer suplemento.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Lycopene help with Atherosclerosis?
            
        
        

            Based on 3 studies with 200 participants, there is preliminary evidence that needs more research that Lycopene may support Atherosclerosis management. Our evidence grade is D (Very Early Research).
        

    

    
    

        
            How much Lycopene should I take for Atherosclerosis?
            
        
        

            Studies have used various dosages. A commonly studied range is 6-15 mg/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Lycopene?
            
        
        

            Reported side effects may include Generally well-tolerated, Lycopenodermia (orange skin discoloration) at very high intake — harmless and reversible. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Lycopene and Atherosclerosis?
            
        
        

            We rate the evidence as Grade D (Very Early Research). This rating is based on 3 peer-reviewed studies with 200 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  




            

                
                
                

                
                

                    
Lycopene para outras condições

                    

                        
                        
                            High Blood Pressure (Hypertension)
                            B

                        
                        
                    

                

                
            

        

        

    


    
    






  
References

  
    
    
    
  1. 
      [1]
      Kazuhiko Nakadate et al..
      Int J Mol Sci.
      2025.
      Anti-Inflammatory Actions of Plant-Derived Compounds and Prevention of Chronic Diseases: From Molecular Mechanisms to Applications.
      doi:10.3390/ijms26115206
      PubMed
    
    2. 
    
    
  2. 
      [2]
      Yuqing Wu et al..
      Clin Nutr.
      2025.
      Functional food lycopene mitigates obesity-related cognitive decline via lipid metabolism regulation and neuroprotection via taurine and glutathione pathway.
      doi:10.1016/j.clnu.2025.06.005
      PubMed
    
    3. 
    
    
  3. 
      [3]
      Shreya Verma et al..
      J Nutr.
      2025.
      Vascular Roads to a Healthier Brain: Lutein Moderates the Influence of Arterial Stiffness on Cognitive Function.
      doi:10.1016/j.tjnut.2025.08.029
      PubMed
    
    4. 
    
    
  4. 
      [4]
      Friederike Wylenzek et al..
      Arch Gynecol Obstet.
      2024.
      A systematic review on the impact of nutrition and possible supplementation on the deficiency of vitamin complexes, iron, omega-3-fatty acids, …
      doi:10.1007/s00404-024-07555-6
      PubMed
    
    5. 
    
    
  5. 
      [5]
      Jolanta Flieger et al..
      Int J Mol Sci.
      2024.
      Carotenoid Supplementation for Alleviating the Symptoms of Alzheimer's Disease.
      doi:10.3390/ijms25168982
      PubMed
    
    6. 
    
    
  6. 
      [6]
      Sitong Wan et al..
      Nutrients.
      2024.
      Antioxidant Lipid Supplement on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis.
      doi:10.3390/nu16142213
      PubMed
    
    7. 
    
    
  7. 
      [7]
      Michael A Grandner et al..
      J Sleep Res.
      2014.
      Sleep symptoms associated with intake of specific dietary nutrients.
      doi:10.1111/jsr.12084
      PubMed
    
    8. 
    
    
  8. 
      [8]
      Graziano Riccioni.
      Curr Atheroscler Rep.
      2009.
      Carotenoids and cardiovascular disease.
      doi:10.1007/s11883-009-0065-z
      PubMed
    
    9. 
    
  















    

        Aviso Legal da FDA:
        Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.