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Vitamin E için Atherosclerosis

C Kanıt Küçük çalışmalardan sınırlı kanıt mevcuttur, ancak bazı olumlu sinyaller bulunmaktadır.

Strong mechanistic rationale (LDL oxidation inhibition) but large RCTs (HOPE, GISSI-Prevenzione) show no benefit. Meta-analysis suggests potential harm at >=400 IU/day. AHA does not recommend supplementation.

C

Sonuç

Strong mechanistic rationale (LDL oxidation inhibition) but large RCTs (HOPE, GISSI-Prevenzione) show no benefit. Meta-analysis suggests potential harm at >=400 IU/day. AHA does not recommend supplementation.

Key Statistics

15

Çalışmalar

50000

Katılımcılar

↔

Mixed

C

Derece

Referenced Papers

Navigating the Effects of Anti-Atherosclerotic Supplements and Acknowledging Associated Bleeding Risks. Review
International journal of … 2025 1 atıf
Extensive Bioactivity of Astaxanthin from Haematococcus pluvialis in Human. Other
Advances in experimental … 2021 13 atıf
Supplementation with Resveratrol, Piperine and Alpha-Tocopherol Decreases Chronic Inflammation in a Cluster of Older Adults with Metabolic Syndrome. Other
Nutrients 2020 16 atıf
Nutrient intake, nutritional status, and cognitive function with aging. Review
Annals of the … 2016 89 atıf
Role of reactive oxygen species and antioxidants in atopic dermatitis. Other
Journal of clinical … 2013 178 atıf
Astaxanthin: a novel potential treatment for oxidative stress and inflammation in cardiovascular disease. Review
The American journal … 2008 441 atıf

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Yaygın Kullanılan Dozajlar

note:
High-dose supplementation no longer recommended based on clinical trial evidence
general:
15 mg/day (22.4 IU)

Üst sınır: 1,000 mg/day (1,500 IU natural, 1,100 IU synthetic)

En iyi alım zamanı: With meals containing fat

Safety & Side Effects

Bildirilen Yan Etkiler

  • ⚠ Increased bleeding risk at high doses
  • ⚠ Possible increased all-cause mortality at >=400 IU/day
  • ⚠ Increased heart failure hospitalization risk (HOPE/HOPE-TOO)
  • ⚠ Nausea, diarrhea, fatigue at high doses

Bilinen Etkileşimler

  • ● Anticoagulants (increased bleeding risk)
  • ● Statins and niacin (may blunt HDL-raising effect)
  • ● Chemotherapy and radiation (theoretical interference with oxidative mechanisms)
  • ● Vitamin K (may antagonize at high doses)

Tolere edilebilir üst alım: 1,000 mg/day (1,500 IU natural, 1,100 IU synthetic)

Herhangi bir takviye kullanmaya başlamadan önce mutlaka sağlık uzmanınıza danışın.Herhangi bir takviye başlatmadan önce her zaman sağlık uzmanınıza danışın.

Frequently Asked Questions

Does Vitamin E help with Atherosclerosis?
Based on 15 studies with 50,000 participants, there is limited but promising evidence that Vitamin E may support Atherosclerosis management. Our evidence grade is C (Some Evidence).
How much Vitamin E should I take for Atherosclerosis?
Studies have used various dosages. A commonly studied range is High-dose supplementation no longer recommended based on clinical trial evidence. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin E?
Reported side effects may include Increased bleeding risk at high doses, Possible increased all-cause mortality at >=400 IU/day, Increased heart failure hospitalization risk (HOPE/HOPE-TOO), Nausea, diarrhea, fatigue at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin E and Atherosclerosis?
We rate the evidence as Grade C (Some Evidence). This rating is based on 15 peer-reviewed studies with 50,000 total participants. The overall direction of effect is mixed.

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References

  
    
    
    
  1. 
      [1]
      Maria-Zinaida Dobre et al..
      Int J Mol Sci.
      2025.
      Navigating the Effects of Anti-Atherosclerotic Supplements and Acknowledging Associated Bleeding Risks.
      doi:10.3390/ijms262010183
      PubMed
    
    2. 
    
    
  2. 
      [2]
      Eiji Yamashita.
      Adv Exp Med Biol.
      2021.
      Extensive Bioactivity of Astaxanthin from Haematococcus pluvialis in Human.
      doi:10.1007/978-981-15-7360-6_23
      PubMed
    
    3. 
    
    
  3. 
      [3]
      Raúl Francisco Pastor et al..
      Nutrients.
      2020.
      Supplementation with Resveratrol, Piperine and Alpha-Tocopherol Decreases Chronic Inflammation in a Cluster of Older Adults with Metabolic Syndrome.
      doi:10.3390/nu12103149
      PubMed
    
    4. 
    
    
  4. 
      [4]
      Katherine L Tucker.
      Ann N Y Acad Sci.
      2016.
      Nutrient intake, nutritional status, and cognitive function with aging.
      doi:10.1111/nyas.13062
      PubMed
    
    5. 
    
    
  5. 
      [5]
      N Sivaranjani et al..
      J Clin Diagn Res.
      2013.
      Role of reactive oxygen species and antioxidants in atopic dermatitis.
      doi:10.7860/JCDR/2013/6635.3732
      PubMed
    
    6. 
    
    
  6. 
      [6]
      Fredric J Pashkow et al..
      Am J Cardiol.
      2008.
      Astaxanthin: a novel potential treatment for oxidative stress and inflammation in cardiovascular disease.
      doi:10.1016/j.amjcard.2008.02.010
      PubMed
    
    7. 
    
  















    

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