Vitamin E per Atherosclerosis

C Evidenze Evidenza limitata da studi di piccole dimensioni, ma esistono alcuni segnali positivi.

Strong mechanistic rationale (LDL oxidation inhibition) but large RCTs (HOPE, GISSI-Prevenzione) show no benefit. Meta-analysis suggests potential harm at >=400 IU/day. AHA does not recommend supplementation.

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In sintesi

Key Study Findings

Review

Navigating the Effects of Anti-Atherosclerotic Supplements and Acknowledging Associated Bleeding Risks.

Dose: None vs: None Outcome: None Effetto: None None

Popolazione: Review of anti-atherosclerotic supplements and bleeding

Other

Extensive Bioactivity of Astaxanthin from Haematococcus pluvialis in Human.

Dose: None vs: None Outcome: None Effetto: None None

Popolazione: None

Other

Supplementation with Resveratrol, Piperine and Alpha-Tocopherol Decreases Chronic Inflammation in a Cluster of Older Adults …

Dose: None vs: Conventional treatment Outcome: effect of a dietary supplement on chronic inflammation … Effetto: None p < 0.05

Popolazione: None

Review

Nutrient intake, nutritional status, and cognitive function with aging.

Dose: None vs: None Outcome: None Effetto: None None

Popolazione: Aging adults (nutrition and cognition)

Review

Role of reactive oxygen species and antioxidants in atopic dermatitis.

Dose: None vs: None Outcome: Role of oxidative stress in atopic dermatitis Effetto: None None

Popolazione: Patients with atopic dermatitis

Review

Astaxanthin: a novel potential treatment for oxidative stress and inflammation in cardiovascular disease.

Dose: None vs: None Outcome: Astaxanthin: a novel potential treatment for oxidative stress … Effetto: None None

Popolazione: None

Key Statistics

Studi

50000

Partecipanti

↔

Mixed

Grado

Referenced Papers

Navigating the Effects of Anti-Atherosclerotic Supplements and Acknowledging Associated Bleeding Risks. Review

International journal of … 2025 1 citazioni

Extensive Bioactivity of Astaxanthin from Haematococcus pluvialis in Human. Other

Advances in experimental … 2021 13 citazioni

Supplementation with Resveratrol, Piperine and Alpha-Tocopherol Decreases Chronic Inflammation in a Cluster of Older Adults with Metabolic Syndrome. Other

Nutrients 2020 16 citazioni

Nutrient intake, nutritional status, and cognitive function with aging. Review

Annals of the … 2016 89 citazioni

Role of reactive oxygen species and antioxidants in atopic dermatitis. Other

Journal of clinical … 2013 178 citazioni

Astaxanthin: a novel potential treatment for oxidative stress and inflammation in cardiovascular disease. Review

The American journal … 2008 441 citazioni

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosaggi di uso comune

note:: High-dose supplementation no longer recommended based on clinical trial evidence
general:: 15 mg/day (22.4 IU)

Limite massimo: 1,000 mg/day (1,500 IU natural, 1,100 IU synthetic)

Dosaggi studiati nella ricerca

Dosaggio	Durata	Effetto	N
None	--	Mixed	--
None	--	Positive	--
None	--	Mixed	--
None	--	Mixed	--
None	--	Positive	--
None	--	Positive	--

Momento migliore per l'assunzione: With meals containing fat

Safety & Side Effects

Effetti collaterali segnalati

⚠ Increased bleeding risk at high doses
⚠ Possible increased all-cause mortality at >=400 IU/day
⚠ Increased heart failure hospitalization risk (HOPE/HOPE-TOO)
⚠ Nausea, diarrhea, fatigue at high doses

Interazioni note

● Anticoagulants (increased bleeding risk)
● Statins and niacin (may blunt HDL-raising effect)
● Chemotherapy and radiation (theoretical interference with oxidative mechanisms)
● Vitamin K (may antagonize at high doses)

Livello di assunzione massimo tollerabile: 1,000 mg/day (1,500 IU natural, 1,100 IU synthetic)

Consultare sempre il proprio medico prima di iniziare qualsiasi integratore.Consultate sempre il vostro medico prima di iniziare qualsiasi integratore.

Frequently Asked Questions

Does Vitamin E help with Atherosclerosis?

Based on 15 studies with 50,000 participants, there is limited but promising evidence that Vitamin E may support Atherosclerosis management. Our evidence grade is C (Some Evidence).

How much Vitamin E should I take for Atherosclerosis?

Studies have used various dosages. A commonly studied range is High-dose supplementation no longer recommended based on clinical trial evidence. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Vitamin E?

Reported side effects may include Increased bleeding risk at high doses, Possible increased all-cause mortality at >=400 IU/day, Increased heart failure hospitalization risk (HOPE/HOPE-TOO), Nausea, diarrhea, fatigue at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Vitamin E and Atherosclerosis?

We rate the evidence as Grade C (Some Evidence). This rating is based on 15 peer-reviewed studies with 50,000 total participants. The overall direction of effect is mixed.

Altri ingredienti per Atherosclerosis

Nattokinase B Resveratrol C Lycopene D Quercetin D Flaxseed Oil D Olive Leaf Extract D

Verdetto rapido

Evidence Strength52%

Moderate confidence

Analisi degli studi

RCT (0)Meta (0)Other (15)

Confronta le alternative

Scoprite come si confrontano altri ingredienti per questa condizione.

Visualizza tutti gli ingredienti per Atherosclerosis

Approfondimenti

References

[1] Maria-Zinaida Dobre et al.. Int J Mol Sci. 2025. Navigating the Effects of Anti-Atherosclerotic Supplements and Acknowledging Associated Bleeding Risks. doi:10.3390/ijms262010183 PubMed
[2] Eiji Yamashita. Adv Exp Med Biol. 2021. Extensive Bioactivity of Astaxanthin from Haematococcus pluvialis in Human. doi:10.1007/978-981-15-7360-6_23 PubMed
[3] Raúl Francisco Pastor et al.. Nutrients. 2020. Supplementation with Resveratrol, Piperine and Alpha-Tocopherol Decreases Chronic Inflammation in a Cluster of Older Adults with Metabolic Syndrome. doi:10.3390/nu12103149 PubMed
[4] Katherine L Tucker. Ann N Y Acad Sci. 2016. Nutrient intake, nutritional status, and cognitive function with aging. doi:10.1111/nyas.13062 PubMed
[5] N Sivaranjani et al.. J Clin Diagn Res. 2013. Role of reactive oxygen species and antioxidants in atopic dermatitis. doi:10.7860/JCDR/2013/6635.3732 PubMed
[6] Fredric J Pashkow et al.. Am J Cardiol. 2008. Astaxanthin: a novel potential treatment for oxidative stress and inflammation in cardiovascular disease. doi:10.1016/j.amjcard.2008.02.010 PubMed

Avvertenza FDA: Queste affermazioni non sono state valutate dalla Food and Drug Administration. I prodotti e le informazioni presenti su questo sito web non sono destinati a diagnosticare, trattare, curare o prevenire alcuna malattia. I gradi di evidenza presentati si basano sulla nostra analisi della ricerca pubblicata e sottoposta a revisione paritaria e non costituiscono consulenza medica. Consultate sempre il vostro medico prima di iniziare qualsiasi regime di integrazione.

Vitamin E per Atherosclerosis

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In sintesi

Key Study Findings

Key Statistics

Referenced Papers

Dosage & Usage

Dosaggi di uso comune

Dosaggi studiati nella ricerca

Safety & Side Effects

Effetti collaterali segnalati

Interazioni note

Frequently Asked Questions

Related Evidence

Altri ingredienti per Atherosclerosis

References