Resveratrol per Atherosclerosis
C Evidenze Evidenza limitata da studi di piccole dimensioni, ma esistono alcuni segnali positivi.Improves FMD and reduces inflammatory markers. RESVACE trial was negative for cardiac function in heart failure. Bioavailability challenges limit clinical translation.
In sintesi
Improves FMD and reduces inflammatory markers. RESVACE trial was negative for cardiac function in heart failure. Bioavailability challenges limit clinical translation.
Key Study Findings
Popolazione: older adults and individuals with neurodegenerative disorders
Popolazione: review of age-related cardiac dysfunction and heart failure mechanisms
Popolazione: Review of anti-atherosclerotic supplements and bleeding
Popolazione: Atherosclerosis populations
Popolazione: None
Popolazione: None
Key Statistics
5
Studi
400
Partecipanti
Positive
Grado
Referenced Papers
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosaggi di uso comune
- general:
- 150-500 mg/day
- cardiovascularsupport:
- 250-500 mg/day trans-resveratrol
Limite massimo: Not formally established; GI discomfort common above 1,000 mg/day
Dosaggi studiati nella ricerca
| Dosaggio | Durata | Effetto | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Neutral | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
Momento migliore per l'assunzione: With meals; bioavailability enhanced by piperine co-supplementation
Safety & Side Effects
Effetti collaterali segnalati
- ⚠ Gastrointestinal discomfort (nausea, diarrhea, cramping) at high doses
- ⚠ Headache
- ⚠ May have estrogenic activity at high doses
Interazioni note
- ● Anticoagulants (may inhibit platelet aggregation)
- ● CYP450 substrates (may inhibit CYP1A2, CYP3A4, CYP2D6)
- ● Blood pressure medications (additive hypotensive effect)
- ● Estrogen-sensitive conditions (weak estrogenic activity)
Livello di assunzione massimo tollerabile: Not formally established; GI discomfort common above 1,000 mg/day
Consultare sempre il proprio medico prima di iniziare qualsiasi integratore.Consultate sempre il vostro medico prima di iniziare qualsiasi integratore.
Frequently Asked Questions
Does Resveratrol help with Atherosclerosis?
How much Resveratrol should I take for Atherosclerosis?
Are there side effects of Resveratrol?
How strong is the evidence for Resveratrol and Atherosclerosis?
Related Evidence
Altri ingredienti per Atherosclerosis
Resveratrol per altre condizioni
References
- [1] Lei Wang et al.. Phytother Res. 2026. Dietary Antioxidants, Polyphenols, and Vascular Health: Insights From Ultrasound Measurement of Carotid Intima-Media Thickness and Their Association With Cognitive Function … doi:10.1002/ptr.70198 PubMed
- [2] Zhuyubing Fang et al.. ESC Heart Fail. 2025. Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues. doi:10.1002/ehf2.14947 PubMed
- [3] Maria-Zinaida Dobre et al.. Int J Mol Sci. 2025. Navigating the Effects of Anti-Atherosclerotic Supplements and Acknowledging Associated Bleeding Risks. doi:10.3390/ijms262010183 PubMed
- [4] Shitian Guo et al.. Biomed Pharmacother. 2022. Resveratrol inhibiting TGF/ERK signaling pathway can improve atherosclerosis: backgrounds, mechanisms and effects. doi:10.1016/j.biopha.2022.113775 PubMed
- [5] Meiming Su et al.. Nutrients. 2022. Genome-Wide Transcriptional Profiling Reveals PHACTR1 as a Novel Molecular Target of Resveratrol in Endothelial Homeostasis. doi:10.3390/nu14214518 PubMed
- [6] Raúl Francisco Pastor et al.. Nutrients. 2020. Supplementation with Resveratrol, Piperine and Alpha-Tocopherol Decreases Chronic Inflammation in a Cluster of Older Adults with Metabolic Syndrome. doi:10.3390/nu12103149 PubMed
- [7] Wang Anlu et al.. Pharmacol Res. 2019. Using herbal medicine to target the "microbiota-metabolism-immunity" axis as possible therapy for cardiovascular disease. doi:10.1016/j.phrs.2019.02.018 PubMed
- [8] Michał Wiciński et al.. Nutrients. 2018. Beneficial Effects of Resveratrol Administration-Focus on Potential Biochemical Mechanisms in Cardiovascular Conditions. doi:10.3390/nu10111813 PubMed
- [9] A Tressera-Rimbau et al.. Oxid Med Cell Longev. 2017. Dietary Polyphenols in the Prevention of Stroke. doi:10.1155/2017/7467962 PubMed
- [10] Enrico Gugliandolo et al.. Pharmacol Res. 2017. Palmitoylethanolamide and Polydatin combination reduces inflammation and oxidative stress in vascular injury. doi:10.1016/j.phrs.2017.06.014 PubMed
- [11] Ling Zhao et al.. Nutr Rev. 2011. Inhibition of pattern recognition receptor-mediated inflammation by bioactive phytochemicals. doi:10.1111/j.1753-4887.2011.00394.x PubMed
- [12] Alberto A A Bertelli et al.. J Cardiovasc Pharmacol. 2009. Grapes, wines, resveratrol, and heart health. doi:10.1097/FJC.0b013e3181bfaff3 PubMed
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