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HeartCited

Vitamin E ： Atherosclerosis

C

Strong mechanistic rationale (LDL oxidation inhibition) but large RCTs (HOPE, GISSI-Prevenzione) show no benefit. Meta-analysis suggests potential harm at >=400 IU/day. AHA does not recommend supplementation.

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            C

        

        

            
結論

            
            
Strong mechanistic rationale (LDL oxidation inhibition) but large RCTs (HOPE, GISSI-Prevenzione) show no benefit. Meta-analysis suggests potential harm at >=400 IU/day. AHA does not recommend supplementation.

            
            
        

    











    
    

        
        

            

  
Key Statistics





            


    

        
15

        
研究数

    

    

        
50000

        
参加者数

    

    

        
            
            ↔
            
        
        
Mixed

    

    

        C

        
グレード

    




        


        
        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
一般的な使用量

                

                    
                    

                        
note:

                        
High-dose supplementation no longer recommended based on clinical trial evidence

                    

                    
                    

                        
general:

                        
15 mg/day (22.4 IU)

                    

                    
                

                
                

                    上限量： 1,000 mg/day (1,500 IU natural, 1,100 IU synthetic)
                

                
            

            

            

            
            

                推奨摂取タイミング： With meals containing fat
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
報告されている副作用

                    
    
                        
                        
  • 
                            ⚠
                            Increased bleeding risk at high doses
                        
    • 
                        
                        
  • 
                            ⚠
                            Possible increased all-cause mortality at >=400 IU/day
                        
    • 
                        
                        
  • 
                            ⚠
                            Increased heart failure hospitalization risk (HOPE/HOPE-TOO)
                        
    • 
                        
                        
  • 
                            ⚠
                            Nausea, diarrhea, fatigue at high doses
                        
    • 
                        
                    

                

                

                
                

                    
既知の相互作用

                    
    
                        
                        
  • 
                            ●
                            Anticoagulants (increased bleeding risk)
                        
    • 
                        
                        
  • 
                            ●
                            Statins and niacin (may blunt HDL-raising effect)
                        
    • 
                        
                        
  • 
                            ●
                            Chemotherapy and radiation (theoretical interference with oxidative mechanisms)
                        
    • 
                        
                        
  • 
                            ●
                            Vitamin K (may antagonize at high doses)
                        
    • 
                        
                    

                

                

                
                

                    

                        耐容上限摂取量： 1,000 mg/day (1,500 IU natural, 1,100 IU synthetic)
                    

                

                
            

            

                サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Vitamin E help with Atherosclerosis?
            
        
        

            Based on 15 studies with 50,000 participants, there is limited but promising evidence that Vitamin E may support Atherosclerosis management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much Vitamin E should I take for Atherosclerosis?
            
        
        

            Studies have used various dosages. A commonly studied range is High-dose supplementation no longer recommended based on clinical trial evidence. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Vitamin E?
            
        
        

            Reported side effects may include Increased bleeding risk at high doses, Possible increased all-cause mortality at >=400 IU/day, Increased heart failure hospitalization risk (HOPE/HOPE-TOO), Nausea, diarrhea, fatigue at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Vitamin E and Atherosclerosis?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 15 peer-reviewed studies with 50,000 total participants. The overall direction of effect is mixed.
        

    

    




        

        

        
        
        

            

  
Related Evidence





            

                
                
                

                
            

        

        

    


    
    












    

        FDAに関する免責事項:
        これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。