Skip to main content
HeartCited

Vitamin E ： Atherosclerosis

C エビデンス 小規模研究からのエビデンスは限られていますが、いくつかの肯定的なシグナルがあります。

Strong mechanistic rationale (LDL oxidation inhibition) but large RCTs (HOPE, GISSI-Prevenzione) show no benefit. Meta-analysis suggests potential harm at >=400 IU/day. AHA does not recommend supplementation.

<\/script>\n
`; }, get iframeSnippet() { const domain = 'heartcited.com'; const params = 'ingredient\u003Dvitamin\u002De\u0026condition\u003Datherosclerosis'; return ``; }, get activeSnippet() { return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet; }, copySnippet() { navigator.clipboard.writeText(this.activeSnippet).then(() => { this.copied = true; setTimeout(() => { this.copied = false; }, 2000); }); } }" @keydown.escape.window="open = false" @click.outside="open = false">

Embed This Widget

Style



      
      
    


    
    

      Widget powered by
      .
      Free, no account required.
    

  




    








    

        

            C

        

        

            
結論

            
            
Strong mechanistic rationale (LDL oxidation inhibition) but large RCTs (HOPE, GISSI-Prevenzione) show no benefit. Meta-analysis suggests potential harm at >=400 IU/day. AHA does not recommend supplementation.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Review
                
                
                
                
            

            
                Navigating the Effects of Anti-Atherosclerotic Supplements and Acknowledging Associated Bleeding Risks.
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: None
                
                
                効果: None
                
                
                None
                
            

            
            
対象集団: Review of anti-atherosclerotic supplements and bleeding

            
        

        
        

            

                
                    Other
                
                
                
                
            

            
                Extensive Bioactivity of Astaxanthin from Haematococcus pluvialis in Human.
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: None
                
                
                効果: None
                
                
                None
                
            

            
            
対象集団: None

            
        

        
        

            

                
                    Other
                
                
                
                
            

            
                Supplementation with Resveratrol, Piperine and Alpha-Tocopherol Decreases Chronic Inflammation in a Cluster of Older Adults …
            
            

                
                Dose: None
                
                
                vs: Conventional treatment
                
                
                Outcome: effect of a dietary supplement on chronic inflammation …
                
                
                効果: None
                
                
                p < 0.05
                
            

            
            
対象集団: None

            
        

        
        

            

                
                    Review
                
                
                
                
            

            
                Nutrient intake, nutritional status, and cognitive function with aging.
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: None
                
                
                効果: None
                
                
                None
                
            

            
            
対象集団: Aging adults (nutrition and cognition)

            
        

        
        

            

                
                    Review
                
                
                
                
            

            
                Role of reactive oxygen species and antioxidants in atopic dermatitis.
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: Role of oxidative stress in atopic dermatitis
                
                
                効果: None
                
                
                None
                
            

            
            
対象集団: Patients with atopic dermatitis

            
        

        
        

            

                
                    Review
                
                
                
                
            

            
                Astaxanthin: a novel potential treatment for oxidative stress and inflammation in cardiovascular disease.
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: Astaxanthin: a novel potential treatment for oxidative stress …
                
                
                効果: None
                
                
                None
                
            

            
            
対象集団: None

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
15

        
研究数

    

    

        
50000

        
参加者数

    

    

        
            
            ↔
            
        
        
Mixed

    

    

        C

        
グレード

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Navigating the Effects of Anti-Atherosclerotic Supplements and Acknowledging Associated Bleeding Risks.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        International journal of …
                        2025
                        
                        1 件の引用
                        
                    

                

                
                

                    

                        
                            Extensive Bioactivity of Astaxanthin from Haematococcus pluvialis in Human.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Advances in experimental …
                        2021
                        
                        13 件の引用
                        
                    

                

                
                

                    

                        
                            Supplementation with Resveratrol, Piperine and Alpha-Tocopherol Decreases Chronic Inflammation in a Cluster of Older Adults with Metabolic Syndrome.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Nutrients
                        2020
                        
                        16 件の引用
                        
                    

                

                
                

                    

                        
                            Nutrient intake, nutritional status, and cognitive function with aging.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Annals of the …
                        2016
                        
                        89 件の引用
                        
                    

                

                
                

                    

                        
                            Role of reactive oxygen species and antioxidants in atopic dermatitis.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Journal of clinical …
                        2013
                        
                        178 件の引用
                        
                    

                

                
                

                    

                        
                            Astaxanthin: a novel potential treatment for oxidative stress and inflammation in cardiovascular disease.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        The American journal …
                        2008
                        
                        441 件の引用
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
一般的な使用量

                

                    
                    

                        
note:

                        
High-dose supplementation no longer recommended based on clinical trial evidence

                    

                    
                    

                        
general:

                        
15 mg/day (22.4 IU)

                    

                    
                

                
                

                    上限量： 1,000 mg/day (1,500 IU natural, 1,100 IU synthetic)
                

                
            

            

            
            

                
研究で検討された用量

                

                    

                        
                            

                                用量
                                期間
                                効果
                                N
                            

                        
                        
                            
                            

                                None
                                --
                                
                                    
                                    Mixed
                                    
                                
                                --
                            

                            
                            

                                None
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                None
                                --
                                
                                    
                                    Mixed
                                    
                                
                                --
                            

                            
                            

                                None
                                --
                                
                                    
                                    Mixed
                                    
                                
                                --
                            

                            
                            

                                None
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                None
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                推奨摂取タイミング： With meals containing fat
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
報告されている副作用

                    
    
                        
                        
  • 
                            ⚠
                            Increased bleeding risk at high doses
                        
    • 
                        
                        
  • 
                            ⚠
                            Possible increased all-cause mortality at >=400 IU/day
                        
    • 
                        
                        
  • 
                            ⚠
                            Increased heart failure hospitalization risk (HOPE/HOPE-TOO)
                        
    • 
                        
                        
  • 
                            ⚠
                            Nausea, diarrhea, fatigue at high doses
                        
    • 
                        
                    

                

                

                
                

                    
既知の相互作用

                    
    
                        
                        
  • 
                            ●
                            Anticoagulants (increased bleeding risk)
                        
    • 
                        
                        
  • 
                            ●
                            Statins and niacin (may blunt HDL-raising effect)
                        
    • 
                        
                        
  • 
                            ●
                            Chemotherapy and radiation (theoretical interference with oxidative mechanisms)
                        
    • 
                        
                        
  • 
                            ●
                            Vitamin K (may antagonize at high doses)
                        
    • 
                        
                    

                

                

                
                

                    

                        耐容上限摂取量： 1,000 mg/day (1,500 IU natural, 1,100 IU synthetic)
                    

                

                
            

            

                サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Vitamin E help with Atherosclerosis?
            
        
        

            Based on 15 studies with 50,000 participants, there is limited but promising evidence that Vitamin E may support Atherosclerosis management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much Vitamin E should I take for Atherosclerosis?
            
        
        

            Studies have used various dosages. A commonly studied range is High-dose supplementation no longer recommended based on clinical trial evidence. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Vitamin E?
            
        
        

            Reported side effects may include Increased bleeding risk at high doses, Possible increased all-cause mortality at >=400 IU/day, Increased heart failure hospitalization risk (HOPE/HOPE-TOO), Nausea, diarrhea, fatigue at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Vitamin E and Atherosclerosis?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 15 peer-reviewed studies with 50,000 total participants. The overall direction of effect is mixed.
        

    

    




        

        

        
        
        

            

  




            

                
                
                

                
            

        

        

    


    
    






  
References

  
    
    
    
  1. 
      [1]
      Maria-Zinaida Dobre et al..
      Int J Mol Sci.
      2025.
      Navigating the Effects of Anti-Atherosclerotic Supplements and Acknowledging Associated Bleeding Risks.
      doi:10.3390/ijms262010183
      PubMed
    
    2. 
    
    
  2. 
      [2]
      Eiji Yamashita.
      Adv Exp Med Biol.
      2021.
      Extensive Bioactivity of Astaxanthin from Haematococcus pluvialis in Human.
      doi:10.1007/978-981-15-7360-6_23
      PubMed
    
    3. 
    
    
  3. 
      [3]
      Raúl Francisco Pastor et al..
      Nutrients.
      2020.
      Supplementation with Resveratrol, Piperine and Alpha-Tocopherol Decreases Chronic Inflammation in a Cluster of Older Adults with Metabolic Syndrome.
      doi:10.3390/nu12103149
      PubMed
    
    4. 
    
    
  4. 
      [4]
      Katherine L Tucker.
      Ann N Y Acad Sci.
      2016.
      Nutrient intake, nutritional status, and cognitive function with aging.
      doi:10.1111/nyas.13062
      PubMed
    
    5. 
    
    
  5. 
      [5]
      N Sivaranjani et al..
      J Clin Diagn Res.
      2013.
      Role of reactive oxygen species and antioxidants in atopic dermatitis.
      doi:10.7860/JCDR/2013/6635.3732
      PubMed
    
    6. 
    
    
  6. 
      [6]
      Fredric J Pashkow et al..
      Am J Cardiol.
      2008.
      Astaxanthin: a novel potential treatment for oxidative stress and inflammation in cardiovascular disease.
      doi:10.1016/j.amjcard.2008.02.010
      PubMed
    
    7. 
    
  















    

        FDAに関する免責事項:
        これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。