Lycopene ： Atherosclerosis
D 研究 予備的な研究（実験室研究、症例報告）のみが存在します。EURAMIC study showed association between adipose lycopene and lower MI risk. Cambridge study improved FMD in CAD patients. Interventional evidence is limited.
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D
結論
EURAMIC study showed association between adipose lycopene and lower MI risk. Cambridge study improved FMD in CAD patients. Interventional evidence is limited.
Key Study Findings
Other
Functional food lycopene mitigates obesity-related cognitive decline via lipid metabolism regulation and neuroprotection via taurine …
Dose: 50 mg/kg lycopene in mice
vs: HFD control mice
Outcome: Cognitive function (Y-maze, MWM, novel object recognition)
効果: None
None
対象集団: HFD-induced obese male C57BL/6 mice
Review
Anti-Inflammatory Actions of Plant-Derived Compounds and Prevention of Chronic Diseases: From Molecular Mechanisms to Applications.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: review of plant-derived anti-inflammatory compounds for chronic disease prevention
Observational Study
n=60
Vascular Roads to a Healthier Brain: Lutein Moderates the Influence of Arterial Stiffness on Cognitive …
Dose: None
vs: None
Outcome: Carotenoid moderation of cfPWV-cognition relationship
効果: Beta=0.53, p=0.04 for lutein moderation
0.02
対象集団: Adults, mean age 38.6, 70% female
Meta-Analysis
Antioxidant Lipid Supplement on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis.
Dose: None
vs: Placebo
Outcome: Blood pressure
効果: None
None
対象集団: None
systematic review
n=90
A systematic review on the impact of nutrition and possible supplementation on the deficiency of …
Dose: None
vs: Placebo
効果: None
None
Randomized Controlled Trial
Carotenoid Supplementation for Alleviating the Symptoms of Alzheimer's Disease.
Dose: None
vs: None
Outcome: Cognitive decline
効果: None
None
対象集団: Alzheimer's disease patients
Key Statistics
3
研究数
200
参加者数
↑
Positive
D
グレード
Referenced Papers
International journal of …
2025
32 件の引用
Clinical nutrition (Edinburgh, …
2025
1 件の引用
The Journal of …
2025
A systematic review on the impact of nutrition and possible supplementation on the deficiency of vitamin complexes, iron, omega-3-fatty acids, …
Systematic Review
Archives of gynecology …
2024
18 件の引用
International journal of …
2024
11 件の引用
Antioxidant Lipid Supplement on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis.
Meta-Analysis
Nutrients
2024
6 件の引用
Journal of sleep …
2014
236 件の引用
Current atherosclerosis reports
2009
122 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 6-15 mg/day
- cardiovascularsupport:
- 15-30 mg/day
上限量： Not formally established; up to 75 mg/day used in clinical trials
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| 50 mg/kg lycopene in mice | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | 60 |
| None | -- | Neutral | -- |
| None | -- | Negative | 90 |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
推奨摂取タイミング： With meals containing fat (cooking with olive oil enhances absorption 2-3x)
Safety & Side Effects
報告されている副作用
- ⚠ Generally well-tolerated
- ⚠ Lycopenodermia (orange skin discoloration) at very high intake — harmless and reversible
既知の相互作用
- ● Blood pressure medications (may have mild additive effect)
- ● Beta-carotene (may compete for absorption)
耐容上限摂取量： Not formally established; up to 75 mg/day used in clinical trials
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Lycopene help with Atherosclerosis?
Based on 3 studies with 200 participants, there is preliminary evidence that needs more research that Lycopene may support Atherosclerosis management. Our evidence grade is D (Very Early Research).
How much Lycopene should I take for Atherosclerosis?
Studies have used various dosages. A commonly studied range is 6-15 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Lycopene?
Reported side effects may include Generally well-tolerated, Lycopenodermia (orange skin discoloration) at very high intake — harmless and reversible. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Lycopene and Atherosclerosis?
We rate the evidence as Grade D (Very Early Research). This rating is based on 3 peer-reviewed studies with 200 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Atherosclerosis
Lycopene 他の症状・状態について
References
- [1] Kazuhiko Nakadate et al.. Int J Mol Sci. 2025. Anti-Inflammatory Actions of Plant-Derived Compounds and Prevention of Chronic Diseases: From Molecular Mechanisms to Applications. doi:10.3390/ijms26115206 PubMed
- [2] Yuqing Wu et al.. Clin Nutr. 2025. Functional food lycopene mitigates obesity-related cognitive decline via lipid metabolism regulation and neuroprotection via taurine and glutathione pathway. doi:10.1016/j.clnu.2025.06.005 PubMed
- [3] Shreya Verma et al.. J Nutr. 2025. Vascular Roads to a Healthier Brain: Lutein Moderates the Influence of Arterial Stiffness on Cognitive Function. doi:10.1016/j.tjnut.2025.08.029 PubMed
- [4] Friederike Wylenzek et al.. Arch Gynecol Obstet. 2024. A systematic review on the impact of nutrition and possible supplementation on the deficiency of vitamin complexes, iron, omega-3-fatty acids, … doi:10.1007/s00404-024-07555-6 PubMed
- [5] Jolanta Flieger et al.. Int J Mol Sci. 2024. Carotenoid Supplementation for Alleviating the Symptoms of Alzheimer's Disease. doi:10.3390/ijms25168982 PubMed
- [6] Sitong Wan et al.. Nutrients. 2024. Antioxidant Lipid Supplement on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis. doi:10.3390/nu16142213 PubMed
- [7] Michael A Grandner et al.. J Sleep Res. 2014. Sleep symptoms associated with intake of specific dietary nutrients. doi:10.1111/jsr.12084 PubMed
- [8] Graziano Riccioni. Curr Atheroscler Rep. 2009. Carotenoids and cardiovascular disease. doi:10.1007/s11883-009-0065-z PubMed
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