Lycopene untuk Atherosclerosis

D Penelitian Hanya penelitian awal yang ada (studi laboratorium, laporan kasus).

EURAMIC study showed association between adipose lycopene and lower MI risk. Cambridge study improved FMD in CAD patients. Interventional evidence is limited.

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Kesimpulan

EURAMIC study showed association between adipose lycopene and lower MI risk. Cambridge study improved FMD in CAD patients. Interventional evidence is limited.

Key Study Findings

Other

Functional food lycopene mitigates obesity-related cognitive decline via lipid metabolism regulation and neuroprotection via taurine …

Dose: 50 mg/kg lycopene in mice vs: HFD control mice Outcome: Cognitive function (Y-maze, MWM, novel object recognition) Efek: None None

Populasi: HFD-induced obese male C57BL/6 mice

Review

Anti-Inflammatory Actions of Plant-Derived Compounds and Prevention of Chronic Diseases: From Molecular Mechanisms to Applications.

Dose: None vs: None Outcome: None Efek: None None

Populasi: review of plant-derived anti-inflammatory compounds for chronic disease prevention

Observational Study n=60

Vascular Roads to a Healthier Brain: Lutein Moderates the Influence of Arterial Stiffness on Cognitive …

Dose: None vs: None Outcome: Carotenoid moderation of cfPWV-cognition relationship Efek: Beta=0.53, p=0.04 for lutein moderation 0.02

Populasi: Adults, mean age 38.6, 70% female

Meta-Analysis

Antioxidant Lipid Supplement on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis.

Dose: None vs: Placebo Outcome: Blood pressure Efek: None None

Populasi: None

systematic review n=90

A systematic review on the impact of nutrition and possible supplementation on the deficiency of …

Dose: None vs: Placebo Efek: None None

Randomized Controlled Trial

Carotenoid Supplementation for Alleviating the Symptoms of Alzheimer's Disease.

Dose: None vs: None Outcome: Cognitive decline Efek: None None

Populasi: Alzheimer's disease patients

Key Statistics

Studi

200

Peserta

↑

Positive

Peringkat

Referenced Papers

Anti-Inflammatory Actions of Plant-Derived Compounds and Prevention of Chronic Diseases: From Molecular Mechanisms to Applications. Review

International journal of … 2025 32 sitasi

Functional food lycopene mitigates obesity-related cognitive decline via lipid metabolism regulation and neuroprotection via taurine and glutathione pathway. Other

Clinical nutrition (Edinburgh, … 2025 1 sitasi

Vascular Roads to a Healthier Brain: Lutein Moderates the Influence of Arterial Stiffness on Cognitive Function. Other

The Journal of … 2025

A systematic review on the impact of nutrition and possible supplementation on the deficiency of vitamin complexes, iron, omega-3-fatty acids, … Systematic Review

Archives of gynecology … 2024 18 sitasi

Carotenoid Supplementation for Alleviating the Symptoms of Alzheimer's Disease. Review

International journal of … 2024 11 sitasi

Antioxidant Lipid Supplement on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis. Meta-Analysis

Nutrients 2024 6 sitasi

Sleep symptoms associated with intake of specific dietary nutrients. Other

Journal of sleep … 2014 236 sitasi

Carotenoids and cardiovascular disease. Review

Current atherosclerosis reports 2009 122 sitasi

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosis yang Umum Digunakan

general:: 6-15 mg/day
cardiovascularsupport:: 15-30 mg/day

Batas atas: Not formally established; up to 75 mg/day used in clinical trials

Dosis yang Diteliti dalam Penelitian

Dosis	Durasi	Efek	N
50 mg/kg lycopene in mice	--	Positive	--
None	--	Positive	--
None	--	Positive	60
None	--	Neutral	--
None	--	Negative	90
None	--	Positive	--
None	--	Mixed	--

Waktu terbaik diminum: With meals containing fat (cooking with olive oil enhances absorption 2-3x)

Safety & Side Effects

Efek Samping yang Dilaporkan

⚠ Generally well-tolerated
⚠ Lycopenodermia (orange skin discoloration) at very high intake — harmless and reversible

Interaksi yang Diketahui

● Blood pressure medications (may have mild additive effect)
● Beta-carotene (may compete for absorption)

Asupan atas yang dapat ditoleransi: Not formally established; up to 75 mg/day used in clinical trials

Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.

Frequently Asked Questions

Does Lycopene help with Atherosclerosis?

Based on 3 studies with 200 participants, there is preliminary evidence that needs more research that Lycopene may support Atherosclerosis management. Our evidence grade is D (Very Early Research).

How much Lycopene should I take for Atherosclerosis?

Studies have used various dosages. A commonly studied range is 6-15 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Lycopene?

Reported side effects may include Generally well-tolerated, Lycopenodermia (orange skin discoloration) at very high intake — harmless and reversible. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Lycopene and Atherosclerosis?

We rate the evidence as Grade D (Very Early Research). This rating is based on 3 peer-reviewed studies with 200 total participants. The overall direction of effect is positive.

Bahan lain untuk Atherosclerosis

Nattokinase B Vitamin E C Resveratrol C Quercetin D Flaxseed Oil D Olive Leaf Extract D

Lycopene untuk kondisi lain

High Blood Pressure (Hypertension) B

Kesimpulan Singkat

EURAMIC study showed association between adipose lycopene and lower MI risk. Cambridge study improved FMD in CAD patients. Interventional evidence is limited.

Evidence Strength30%

Low confidence

Rincian Studi

RCT (0)Meta (1)Other (2)

Bandingkan Alternatif

Lihat bagaimana bahan lain dibandingkan untuk kondisi ini.

Lihat semua bahan untuk Atherosclerosis

Pelajari Lebih Lanjut

References

[1] Kazuhiko Nakadate et al.. Int J Mol Sci. 2025. Anti-Inflammatory Actions of Plant-Derived Compounds and Prevention of Chronic Diseases: From Molecular Mechanisms to Applications. doi:10.3390/ijms26115206 PubMed
[2] Yuqing Wu et al.. Clin Nutr. 2025. Functional food lycopene mitigates obesity-related cognitive decline via lipid metabolism regulation and neuroprotection via taurine and glutathione pathway. doi:10.1016/j.clnu.2025.06.005 PubMed
[3] Shreya Verma et al.. J Nutr. 2025. Vascular Roads to a Healthier Brain: Lutein Moderates the Influence of Arterial Stiffness on Cognitive Function. doi:10.1016/j.tjnut.2025.08.029 PubMed
[4] Friederike Wylenzek et al.. Arch Gynecol Obstet. 2024. A systematic review on the impact of nutrition and possible supplementation on the deficiency of vitamin complexes, iron, omega-3-fatty acids, … doi:10.1007/s00404-024-07555-6 PubMed
[5] Jolanta Flieger et al.. Int J Mol Sci. 2024. Carotenoid Supplementation for Alleviating the Symptoms of Alzheimer's Disease. doi:10.3390/ijms25168982 PubMed
[6] Sitong Wan et al.. Nutrients. 2024. Antioxidant Lipid Supplement on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis. doi:10.3390/nu16142213 PubMed
[7] Michael A Grandner et al.. J Sleep Res. 2014. Sleep symptoms associated with intake of specific dietary nutrients. doi:10.1111/jsr.12084 PubMed
[8] Graziano Riccioni. Curr Atheroscler Rep. 2009. Carotenoids and cardiovascular disease. doi:10.1007/s11883-009-0065-z PubMed

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Lycopene untuk Atherosclerosis

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Kesimpulan

Key Study Findings

Key Statistics

Referenced Papers

Dosage & Usage

Dosis yang Umum Digunakan

Dosis yang Diteliti dalam Penelitian

Safety & Side Effects

Efek Samping yang Dilaporkan

Interaksi yang Diketahui

Frequently Asked Questions

Related Evidence

Bahan lain untuk Atherosclerosis

Lycopene untuk kondisi lain

References