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Lycopene untuk High Blood Pressure (Hypertension)

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Meta-analysis of 6 RCTs: systolic -5.6 mmHg. Improved endothelial function. Cooking with oil enhances absorption 2-3x. Strong observational associations with lower MI risk.

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Kesimpulan

            
            
Meta-analysis of 6 RCTs: systolic -5.6 mmHg. Improved endothelial function. Cooking with oil enhances absorption 2-3x. Strong observational associations with lower MI risk.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Review
                
                
                
                
            

            
                Dietary supplements and prevention of preeclampsia.
            
            

                
                Dose: 500 mg daily
                
                
                vs: Placebo
                
                
                Outcome: Preeclampsia risk reduction
                
                
                Efek: ~50% risk reduction
                
                
                None
                
            

            
            
Populasi: Pregnant women with low calcium intake

            
        

        
        

            

                
                    Randomized Controlled Trial
                
                
                n=442
                
                
                156 weeks
                
                
                Open-label
                
            

            
                Apolipoprotein E ε4-dependent associations between carotenoids and cognitive decline: Findings from the MIND (Mediterranean-DASH Intervention …
            
            

                
                Dose: None
                
                
                vs: Usual diet
                
                
                Outcome: 3-year change in global cognitive function (composite)
                
                
                Efek: β=0.17 SU per unit carotenoid (APOE ε4)
                
                
                0.009
                
            

            
            
Populasi: Older adults ≥65y, BMI>25, family history of AD, MoCA≥22

            
        

        
        

            

                
                    Meta-Analysis
                
                
                
                
            

            
                Antioxidant Lipid Supplement on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis.
            
            

                
                Dose: None
                
                
                vs: Placebo
                
                
                Outcome: Blood pressure
                
                
                Efek: None
                
                
                None
                
            

            
            
Populasi: None

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
6

        
Studi

    

    

        
400

        
Peserta

    

    

        
            
            ↑
            
        
        
Positive

    

    

        B

        
Peringkat

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Dietary supplements and prevention of preeclampsia.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Hypertension research : …
                        2025
                        
                        10 sitasi
                        
                    

                

                
                

                    

                        
                            Apolipoprotein E ε4-dependent associations between carotenoids and cognitive decline: Findings from the MIND (Mediterranean-DASH Intervention for Neurodegenerative delay) randomized controlled …
                        
                        
                            
                                RCT
                            
                            
                            
                        
                    

                    

                        The American journal …
                        2025
                        
                        2 sitasi
                        
                    

                

                
                

                    

                        
                            Antioxidant Lipid Supplement on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis.
                        
                        
                            
                                Meta-Analysis
                            
                            
                            
                        
                    

                    

                        Nutrients
                        2024
                        
                        6 sitasi
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Dosis yang Umum Digunakan

                

                    
                    

                        
general:

                        
6-15 mg/day

                    

                    
                    

                        
cardiovascularsupport:

                        
15-30 mg/day

                    

                    
                

                
                

                    Batas atas: Not formally established; up to 75 mg/day used in clinical trials
                

                
            

            

            
            

                
Dosis yang Diteliti dalam Penelitian

                

                    

                        
                            

                                Dosis
                                Durasi
                                Efek
                                N
                            

                        
                        
                            
                            

                                500 mg daily
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                None
                                156 weeks
                                
                                    
                                    Positive
                                    
                                
                                442
                            

                            
                            

                                None
                                --
                                
                                    
                                    Neutral
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                Waktu terbaik diminum: With meals containing fat (cooking with olive oil enhances absorption 2-3x)
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Efek Samping yang Dilaporkan

                    
    
                        
                        
  • 
                            ⚠
                            Generally well-tolerated
                        
    • 
                        
                        
  • 
                            ⚠
                            Lycopenodermia (orange skin discoloration) at very high intake — harmless and reversible
                        
    • 
                        
                    

                

                

                
                

                    
Interaksi yang Diketahui

                    
    
                        
                        
  • 
                            ●
                            Blood pressure medications (may have mild additive effect)
                        
    • 
                        
                        
  • 
                            ●
                            Beta-carotene (may compete for absorption)
                        
    • 
                        
                    

                

                

                
                

                    

                        Asupan atas yang dapat ditoleransi: Not formally established; up to 75 mg/day used in clinical trials
                    

                

                
            

            

                Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Lycopene help with High Blood Pressure (Hypertension)?
            
        
        

            Based on 6 studies with 400 participants, there is moderate evidence from clinical studies that Lycopene may support High Blood Pressure (Hypertension) management. Our evidence grade is B (Good Evidence).
        

    

    
    

        
            How much Lycopene should I take for High Blood Pressure (Hypertension)?
            
        
        

            Studies have used various dosages. A commonly studied range is 6-15 mg/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Lycopene?
            
        
        

            Reported side effects may include Generally well-tolerated, Lycopenodermia (orange skin discoloration) at very high intake — harmless and reversible. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Lycopene and High Blood Pressure (Hypertension)?
            
        
        

            We rate the evidence as Grade B (Good Evidence). This rating is based on 6 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  




            

                
                
                

                
                

                    
Lycopene untuk kondisi lain

                    

                        
                        
                            Atherosclerosis
                            D

                        
                        
                    

                

                
            

        

        

    


    
    






  
References

  
    
    
    
  1. 
      [1]
      Takafumi Ushida et al..
      Hypertens Res.
      2025.
      Dietary supplements and prevention of preeclampsia.
      doi:10.1038/s41440-025-02144-9
      PubMed
    
    2. 
    
    
  2. 
      [2]
      Xiaoran Liu et al..
      Am J Clin Nutr.
      2025.
      Apolipoprotein E ε4-dependent associations between carotenoids and cognitive decline: Findings from the MIND (Mediterranean-DASH Intervention for Neurodegenerative delay) randomized controlled …
      doi:10.1016/j.ajcnut.2025.08.012
      PubMed
    
    3. 
    
    
  3. 
      [3]
      Sitong Wan et al..
      Nutrients.
      2024.
      Antioxidant Lipid Supplement on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis.
      doi:10.3390/nu16142213
      PubMed
    
    4. 
    
  















    

        Penafian FDA:
        Pernyataan-pernyataan ini belum dievaluasi oleh Food and Drug Administration. Produk dan informasi di situs web ini tidak dimaksudkan untuk mendiagnosis, mengobati, menyembuhkan, atau mencegah penyakit apa pun. Peringkat bukti yang disajikan didasarkan pada analisis kami terhadap penelitian yang ditinjau sejawat dan tidak merupakan saran medis. Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai regimen suplemen apa pun.