Calcium untuk High Blood Pressure (Hypertension)

C Bukti Bukti terbatas dari studi kecil, namun beberapa sinyal positif ada.

Small meta-analytic BP reduction (-1.4 mmHg systolic). Overwhelmed by cardiovascular safety concerns from supplement studies. Dietary calcium preferred.

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Kesimpulan

Small meta-analytic BP reduction (-1.4 mmHg systolic). Overwhelmed by cardiovascular safety concerns from supplement studies. Dietary calcium preferred.

Key Study Findings

Meta-Analysis

Associations between Diet and Cognitive Function in Stroke Survivors: A Systematic Review and Meta-analysis.

Dose: None vs: Standard care or placebo Outcome: Global cognition in stroke survivors Efek: SMD=0.62 (energy-protein); SMD=-0.40 (B-vitamins) 0.009 (protein); 0.02 (B-vit)

Populasi: Adult stroke survivors (20 trials + 14 observational)

Review

Dietary supplements and prevention of preeclampsia.

Dose: 500 mg daily vs: Placebo Outcome: Preeclampsia risk reduction Efek: ~50% risk reduction None

Populasi: Pregnant women with low calcium intake

Review

Novel pharmacologic approaches in resistant hypertension.

Dose: Spironolactone, sacubitril/valsartan, SGLT2i vs: None Outcome: Blood pressure control in resistant HTN Efek: None None

Populasi: Patients with resistant hypertension

Review

Vegan Diet Health Benefits in Metabolic Syndrome.

Dose: None vs: None Outcome: None Efek: None None

Populasi: Adults with metabolic syndrome

cross-sectional observational study n=260

Restless leg syndrome in chronic hemodialysis patients in Mashhad hemodialysis centers.

Dose: None vs: Placebo Efek: None None

Observational Study n=40

Efficacy and effectiveness of anti-digoxin antibodies in chronic digoxin poisonings from the DORA study (ATOM-1).

Dose: anti-digoxin antibodies (Fab) vs: pre-treatment Outcome: serum digoxin and clinical outcomes Efek: Fab bound digoxin; no improved clinical outcomes None

Populasi: Chronic digoxin toxicity patients

Key Statistics

Studi

1500

Peserta

↔

Mixed

Peringkat

Referenced Papers

Dietary supplements and prevention of preeclampsia. Review

Hypertension research : … 2025 10 sitasi

Associations between Diet and Cognitive Function in Stroke Survivors: A Systematic Review and Meta-analysis. Meta-Analysis

Advances in nutrition … 2025 1 sitasi

Novel pharmacologic approaches in resistant hypertension. Review

Wiadomosci lekarskie (Warsaw, … 2024

Vegan Diet Health Benefits in Metabolic Syndrome. Review

Nutrients 2021 113 sitasi

Restless leg syndrome in chronic hemodialysis patients in Mashhad hemodialysis centers. Other

Journal of renal … 2017 26 sitasi

Efficacy and effectiveness of anti-digoxin antibodies in chronic digoxin poisonings from the DORA study (ATOM-1). Observational

Clinical toxicology (Philadelphia, … 2016 25 sitasi

Emerging concepts for patients with treatment-resistant hypertension. Review

Trends in cardiovascular … 2016 19 sitasi

Restless leg syndrome: a neglected diagnosis. Review

Nephro-urology monthly 2014 43 sitasi

[Clinical characteristics and combined use of medicine analysis of 2 991 hospitalized patients with psoriasis based on real world database]. Other

Zhongguo Zhong yao … 2014 4 sitasi

Vitamin D in health and disease: a literature review. Review

British journal of … 2013 156 sitasi

Vitamin D and autoimmune disease. Review

Acta medica Indonesiana 2007 4 sitasi

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosis yang Umum Digunakan

note:: Prefer dietary sources; limit supplements to 500 mg/dose
general:: 1,000-1,200 mg/day from diet plus supplements

Batas atas: 2,000-2,500 mg/day (total from diet and supplements)

Dosis yang Diteliti dalam Penelitian

Dosis	Durasi	Efek	N
None	--	Mixed	--
500 mg daily	--	Positive	--
Spironolactone, sacubitril/valsartan, SGLT2i	--	Positive	--
None	--	Mixed	--
None	--	Neutral	260
anti-digoxin antibodies (Fab)	--	Neutral	40
None	--	Mixed	--
None	--	Neutral	2991

Waktu terbaik diminum: Divide doses (500 mg max per dose); carbonate with meals; citrate any time

Safety & Side Effects

Efek Samping yang Dilaporkan

⚠ Constipation (especially carbonate form)
⚠ Potential increased MI risk with high-dose supplements (controversial)
⚠ Kidney stones at excessive doses
⚠ Gas, bloating

Interaksi yang Diketahui

● Thyroid medications (separate by 4 hours)
● Bisphosphonates (separate by 30-60 minutes)
● Iron supplements (reduced absorption — separate by 2 hours)
● Certain antibiotics (reduced absorption)
● Vitamin K2 (may help direct supplemental calcium to bones, not arteries)

Asupan atas yang dapat ditoleransi: 2,000-2,500 mg/day (total from diet and supplements)

Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.

Frequently Asked Questions

Does Calcium help with High Blood Pressure (Hypertension)?

Based on 13 studies with 1,500 participants, there is limited but promising evidence that Calcium may support High Blood Pressure (Hypertension) management. Our evidence grade is C (Some Evidence).

How much Calcium should I take for High Blood Pressure (Hypertension)?

Studies have used various dosages. A commonly studied range is Prefer dietary sources; limit supplements to 500 mg/dose. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Calcium?

Reported side effects may include Constipation (especially carbonate form), Potential increased MI risk with high-dose supplements (controversial), Kidney stones at excessive doses, Gas, bloating. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Calcium and High Blood Pressure (Hypertension)?

We rate the evidence as Grade C (Some Evidence). This rating is based on 13 peer-reviewed studies with 1,500 total participants. The overall direction of effect is mixed.

Bahan lain untuk High Blood Pressure (Hypertension)

Beetroot Extract A Garlic A Magnesium B Potassium B Quercetin B Grape Seed Extract B

Kesimpulan Singkat

Small meta-analytic BP reduction (-1.4 mmHg systolic). Overwhelmed by cardiovascular safety concerns from supplement studies. Dietary calcium preferred.

Evidence Strength52%

Moderate confidence

Rincian Studi

RCT (0)Meta (1)Other (12)

Bandingkan Alternatif

Lihat bagaimana bahan lain dibandingkan untuk kondisi ini.

Lihat semua bahan untuk High Blood Pressure (Hypertension)

Pelajari Lebih Lanjut

References

[1] Takafumi Ushida et al.. Hypertens Res. 2025. Dietary supplements and prevention of preeclampsia. doi:10.1038/s41440-025-02144-9 PubMed
[2] Sasan Amanat et al.. Adv Nutr. 2025. Associations between Diet and Cognitive Function in Stroke Survivors: A Systematic Review and Meta-analysis. doi:10.1016/j.advnut.2025.100440 PubMed
[3] Jerzy Głuszek. Wiad Lek. 2024. Novel pharmacologic approaches in resistant hypertension. doi:10.36740/WLek/194090 PubMed
[4] Giulia Marrone et al.. Nutrients. 2021. Vegan Diet Health Benefits in Metabolic Syndrome. doi:10.3390/nu13030817 PubMed
[5] Niloufar Zadeh Saraji et al.. J Renal Inj Prev. 2017. Restless leg syndrome in chronic hemodialysis patients in Mashhad hemodialysis centers. doi:10.15171/jrip.2017.27 PubMed
[6] Betty S Chan et al.. Clin Toxicol (Phila). 2016. Efficacy and effectiveness of anti-digoxin antibodies in chronic digoxin poisonings from the DORA study (ATOM-1). doi:10.1080/15563650.2016.1175620 PubMed
[7] Alfonso Eirin et al.. Trends Cardiovasc Med. 2016. Emerging concepts for patients with treatment-resistant hypertension. doi:10.1016/j.tcm.2016.05.004 PubMed
[8] Behzad Einollahi et al.. Nephrourol Mon. 2014. Restless leg syndrome: a neglected diagnosis. doi:10.5812/numonthly.22009 PubMed
[9] Jian-hong Li et al.. Zhongguo Zhong Yao Za Zhi. 2014. [Clinical characteristics and combined use of medicine analysis of 2 991 hospitalized patients with psoriasis based on real world database]. PubMed
[10] S Basit. Br J Biomed Sci. 2013. Vitamin D in health and disease: a literature review. doi:10.1080/09674845.2013.11669951 PubMed
[11] Eka Ginanjar et al.. Acta Med Indones. 2007. Vitamin D and autoimmune disease. PubMed

Penafian FDA: Pernyataan-pernyataan ini belum dievaluasi oleh Food and Drug Administration. Produk dan informasi di situs web ini tidak dimaksudkan untuk mendiagnosis, mengobati, menyembuhkan, atau mencegah penyakit apa pun. Peringkat bukti yang disajikan didasarkan pada analisis kami terhadap penelitian yang ditinjau sejawat dan tidak merupakan saran medis. Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai regimen suplemen apa pun.

Calcium untuk High Blood Pressure (Hypertension)

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Kesimpulan

Key Study Findings

Key Statistics

Referenced Papers

Dosage & Usage

Dosis yang Umum Digunakan

Dosis yang Diteliti dalam Penelitian

Safety & Side Effects

Efek Samping yang Dilaporkan

Interaksi yang Diketahui

Frequently Asked Questions

Related Evidence

Bahan lain untuk High Blood Pressure (Hypertension)

References