Calcium для High Blood Pressure (Hypertension)

C Доказательства Доказательства ограничены небольшими исследованиями, однако имеются некоторые положительные сигналы.

Small meta-analytic BP reduction (-1.4 mmHg systolic). Overwhelmed by cardiovascular safety concerns from supplement studies. Dietary calcium preferred.

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Итог

Small meta-analytic BP reduction (-1.4 mmHg systolic). Overwhelmed by cardiovascular safety concerns from supplement studies. Dietary calcium preferred.

Key Study Findings

Meta-Analysis

Associations between Diet and Cognitive Function in Stroke Survivors: A Systematic Review and Meta-analysis.

Dose: None или: Standard care or placebo Outcome: Global cognition in stroke survivors Эффект: SMD=0.62 (energy-protein); SMD=-0.40 (B-vitamins) 0.009 (protein); 0.02 (B-vit)

Популяция: Adult stroke survivors (20 trials + 14 observational)

Review

Dietary supplements and prevention of preeclampsia.

Dose: 500 mg daily или: Placebo Outcome: Preeclampsia risk reduction Эффект: ~50% risk reduction None

Популяция: Pregnant women with low calcium intake

Review

Novel pharmacologic approaches in resistant hypertension.

Dose: Spironolactone, sacubitril/valsartan, SGLT2i или: None Outcome: Blood pressure control in resistant HTN Эффект: None None

Популяция: Patients with resistant hypertension

Review

Vegan Diet Health Benefits in Metabolic Syndrome.

Dose: None или: None Outcome: None Эффект: None None

Популяция: Adults with metabolic syndrome

cross-sectional observational study n=260

Restless leg syndrome in chronic hemodialysis patients in Mashhad hemodialysis centers.

Dose: None или: Placebo Эффект: None None

Observational Study n=40

Efficacy and effectiveness of anti-digoxin antibodies in chronic digoxin poisonings from the DORA study (ATOM-1).

Dose: anti-digoxin antibodies (Fab) или: pre-treatment Outcome: serum digoxin and clinical outcomes Эффект: Fab bound digoxin; no improved clinical outcomes None

Популяция: Chronic digoxin toxicity patients

Key Statistics

Исследования

1500

Участники

↔

Mixed

Оценка

Referenced Papers

Dietary supplements and prevention of preeclampsia. Review

Hypertension research : … 2025 10 цитирований

Associations between Diet and Cognitive Function in Stroke Survivors: A Systematic Review and Meta-analysis. Meta-Analysis

Advances in nutrition … 2025 1 цитирований

Novel pharmacologic approaches in resistant hypertension. Review

Wiadomosci lekarskie (Warsaw, … 2024

Vegan Diet Health Benefits in Metabolic Syndrome. Review

Nutrients 2021 113 цитирований

Restless leg syndrome in chronic hemodialysis patients in Mashhad hemodialysis centers. Other

Journal of renal … 2017 26 цитирований

Efficacy and effectiveness of anti-digoxin antibodies in chronic digoxin poisonings from the DORA study (ATOM-1). Observational

Clinical toxicology (Philadelphia, … 2016 25 цитирований

Emerging concepts for patients with treatment-resistant hypertension. Review

Trends in cardiovascular … 2016 19 цитирований

Restless leg syndrome: a neglected diagnosis. Review

Nephro-urology monthly 2014 43 цитирований

[Clinical characteristics and combined use of medicine analysis of 2 991 hospitalized patients with psoriasis based on real world database]. Other

Zhongguo Zhong yao … 2014 4 цитирований

Vitamin D in health and disease: a literature review. Review

British journal of … 2013 156 цитирований

Vitamin D and autoimmune disease. Review

Acta medica Indonesiana 2007 4 цитирований

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Часто используемые дозировки

note:: Prefer dietary sources; limit supplements to 500 mg/dose
general:: 1,000-1,200 mg/day from diet plus supplements

Верхний предел: 2,000-2,500 mg/day (total from diet and supplements)

Дозировки, изученные в исследованиях

Дозировка	Длительность	Эффект	N
None	--	Mixed	--
500 mg daily	--	Positive	--
Spironolactone, sacubitril/valsartan, SGLT2i	--	Positive	--
None	--	Mixed	--
None	--	Neutral	260
anti-digoxin antibodies (Fab)	--	Neutral	40
None	--	Mixed	--
None	--	Neutral	2991

Лучшее время приёма: Divide doses (500 mg max per dose); carbonate with meals; citrate any time

Safety & Side Effects

Зарегистрированные побочные эффекты

⚠ Constipation (especially carbonate form)
⚠ Potential increased MI risk with high-dose supplements (controversial)
⚠ Kidney stones at excessive doses
⚠ Gas, bloating

Известные взаимодействия

● Thyroid medications (separate by 4 hours)
● Bisphosphonates (separate by 30-60 minutes)
● Iron supplements (reduced absorption — separate by 2 hours)
● Certain antibiotics (reduced absorption)
● Vitamin K2 (may help direct supplemental calcium to bones, not arteries)

Допустимый верхний уровень потребления: 2,000-2,500 mg/day (total from diet and supplements)

Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.

Frequently Asked Questions

Does Calcium help with High Blood Pressure (Hypertension)?

Based on 13 studies with 1,500 participants, there is limited but promising evidence that Calcium may support High Blood Pressure (Hypertension) management. Our evidence grade is C (Some Evidence).

How much Calcium should I take for High Blood Pressure (Hypertension)?

Studies have used various dosages. A commonly studied range is Prefer dietary sources; limit supplements to 500 mg/dose. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Calcium?

Reported side effects may include Constipation (especially carbonate form), Potential increased MI risk with high-dose supplements (controversial), Kidney stones at excessive doses, Gas, bloating. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Calcium and High Blood Pressure (Hypertension)?

We rate the evidence as Grade C (Some Evidence). This rating is based on 13 peer-reviewed studies with 1,500 total participants. The overall direction of effect is mixed.

Другие ингредиенты для High Blood Pressure (Hypertension)

Beetroot Extract A Garlic A Magnesium B Potassium B Quercetin B Grape Seed Extract B

Краткий вывод

Small meta-analytic BP reduction (-1.4 mmHg systolic). Overwhelmed by cardiovascular safety concerns from supplement studies. Dietary calcium preferred.

Evidence Strength52%

Moderate confidence

Разбор исследований

RCT (0)Meta (1)Other (12)

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References

[1] Takafumi Ushida et al.. Hypertens Res. 2025. Dietary supplements and prevention of preeclampsia. doi:10.1038/s41440-025-02144-9 PubMed
[2] Sasan Amanat et al.. Adv Nutr. 2025. Associations between Diet and Cognitive Function in Stroke Survivors: A Systematic Review and Meta-analysis. doi:10.1016/j.advnut.2025.100440 PubMed
[3] Jerzy Głuszek. Wiad Lek. 2024. Novel pharmacologic approaches in resistant hypertension. doi:10.36740/WLek/194090 PubMed
[4] Giulia Marrone et al.. Nutrients. 2021. Vegan Diet Health Benefits in Metabolic Syndrome. doi:10.3390/nu13030817 PubMed
[5] Niloufar Zadeh Saraji et al.. J Renal Inj Prev. 2017. Restless leg syndrome in chronic hemodialysis patients in Mashhad hemodialysis centers. doi:10.15171/jrip.2017.27 PubMed
[6] Betty S Chan et al.. Clin Toxicol (Phila). 2016. Efficacy and effectiveness of anti-digoxin antibodies in chronic digoxin poisonings from the DORA study (ATOM-1). doi:10.1080/15563650.2016.1175620 PubMed
[7] Alfonso Eirin et al.. Trends Cardiovasc Med. 2016. Emerging concepts for patients with treatment-resistant hypertension. doi:10.1016/j.tcm.2016.05.004 PubMed
[8] Behzad Einollahi et al.. Nephrourol Mon. 2014. Restless leg syndrome: a neglected diagnosis. doi:10.5812/numonthly.22009 PubMed
[9] Jian-hong Li et al.. Zhongguo Zhong Yao Za Zhi. 2014. [Clinical characteristics and combined use of medicine analysis of 2 991 hospitalized patients with psoriasis based on real world database]. PubMed
[10] S Basit. Br J Biomed Sci. 2013. Vitamin D in health and disease: a literature review. doi:10.1080/09674845.2013.11669951 PubMed
[11] Eka Ginanjar et al.. Acta Med Indones. 2007. Vitamin D and autoimmune disease. PubMed

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Calcium для High Blood Pressure (Hypertension)

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Итог

Key Study Findings

Key Statistics

Referenced Papers

Dosage & Usage

Часто используемые дозировки

Дозировки, изученные в исследованиях

Safety & Side Effects

Зарегистрированные побочные эффекты

Известные взаимодействия

Frequently Asked Questions

Related Evidence

Другие ингредиенты для High Blood Pressure (Hypertension)

References