Calcium cho High Blood Pressure (Hypertension)

C Bằng chứng Bằng chứng hạn chế từ các nghiên cứu nhỏ, nhưng có một số tín hiệu tích cực.

Small meta-analytic BP reduction (-1.4 mmHg systolic). Overwhelmed by cardiovascular safety concerns from supplement studies. Dietary calcium preferred.

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Kết luận

Small meta-analytic BP reduction (-1.4 mmHg systolic). Overwhelmed by cardiovascular safety concerns from supplement studies. Dietary calcium preferred.

Key Study Findings

Meta-Analysis

Associations between Diet and Cognitive Function in Stroke Survivors: A Systematic Review and Meta-analysis.

Dose: None so với: Standard care or placebo Outcome: Global cognition in stroke survivors Hiệu quả: SMD=0.62 (energy-protein); SMD=-0.40 (B-vitamins) 0.009 (protein); 0.02 (B-vit)

Đối tượng nghiên cứu: Adult stroke survivors (20 trials + 14 observational)

Review

Dietary supplements and prevention of preeclampsia.

Dose: 500 mg daily so với: Placebo Outcome: Preeclampsia risk reduction Hiệu quả: ~50% risk reduction None

Đối tượng nghiên cứu: Pregnant women with low calcium intake

Review

Novel pharmacologic approaches in resistant hypertension.

Dose: Spironolactone, sacubitril/valsartan, SGLT2i so với: None Outcome: Blood pressure control in resistant HTN Hiệu quả: None None

Đối tượng nghiên cứu: Patients with resistant hypertension

Review

Vegan Diet Health Benefits in Metabolic Syndrome.

Dose: None so với: None Outcome: None Hiệu quả: None None

Đối tượng nghiên cứu: Adults with metabolic syndrome

cross-sectional observational study n=260

Restless leg syndrome in chronic hemodialysis patients in Mashhad hemodialysis centers.

Dose: None so với: Placebo Hiệu quả: None None

Observational Study n=40

Efficacy and effectiveness of anti-digoxin antibodies in chronic digoxin poisonings from the DORA study (ATOM-1).

Dose: anti-digoxin antibodies (Fab) so với: pre-treatment Outcome: serum digoxin and clinical outcomes Hiệu quả: Fab bound digoxin; no improved clinical outcomes None

Đối tượng nghiên cứu: Chronic digoxin toxicity patients

Key Statistics

Nghiên cứu

1500

Người tham gia

↔

Mixed

Xếp hạng

Referenced Papers

Dietary supplements and prevention of preeclampsia. Review

Hypertension research : … 2025 10 trích dẫn

Associations between Diet and Cognitive Function in Stroke Survivors: A Systematic Review and Meta-analysis. Meta-Analysis

Advances in nutrition … 2025 1 trích dẫn

Novel pharmacologic approaches in resistant hypertension. Review

Wiadomosci lekarskie (Warsaw, … 2024

Vegan Diet Health Benefits in Metabolic Syndrome. Review

Nutrients 2021 113 trích dẫn

Restless leg syndrome in chronic hemodialysis patients in Mashhad hemodialysis centers. Other

Journal of renal … 2017 26 trích dẫn

Efficacy and effectiveness of anti-digoxin antibodies in chronic digoxin poisonings from the DORA study (ATOM-1). Observational

Clinical toxicology (Philadelphia, … 2016 25 trích dẫn

Emerging concepts for patients with treatment-resistant hypertension. Review

Trends in cardiovascular … 2016 19 trích dẫn

Restless leg syndrome: a neglected diagnosis. Review

Nephro-urology monthly 2014 43 trích dẫn

[Clinical characteristics and combined use of medicine analysis of 2 991 hospitalized patients with psoriasis based on real world database]. Other

Zhongguo Zhong yao … 2014 4 trích dẫn

Vitamin D in health and disease: a literature review. Review

British journal of … 2013 156 trích dẫn

Vitamin D and autoimmune disease. Review

Acta medica Indonesiana 2007 4 trích dẫn

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Liều lượng thường dùng

note:: Prefer dietary sources; limit supplements to 500 mg/dose
general:: 1,000-1,200 mg/day from diet plus supplements

Giới hạn trên: 2,000-2,500 mg/day (total from diet and supplements)

Liều lượng đã nghiên cứu

Liều lượng	Thời gian	Hiệu quả	N
None	--	Mixed	--
500 mg daily	--	Positive	--
Spironolactone, sacubitril/valsartan, SGLT2i	--	Positive	--
None	--	Mixed	--
None	--	Neutral	260
anti-digoxin antibodies (Fab)	--	Neutral	40
None	--	Mixed	--
None	--	Neutral	2991

Thời điểm dùng tốt nhất: Divide doses (500 mg max per dose); carbonate with meals; citrate any time

Safety & Side Effects

Tác dụng phụ đã được báo cáo

⚠ Constipation (especially carbonate form)
⚠ Potential increased MI risk with high-dose supplements (controversial)
⚠ Kidney stones at excessive doses
⚠ Gas, bloating

Tương tác đã biết

● Thyroid medications (separate by 4 hours)
● Bisphosphonates (separate by 30-60 minutes)
● Iron supplements (reduced absorption — separate by 2 hours)
● Certain antibiotics (reduced absorption)
● Vitamin K2 (may help direct supplemental calcium to bones, not arteries)

Mức hấp thụ tối đa cho phép: 2,000-2,500 mg/day (total from diet and supplements)

Luôn tham khảo ý kiến bác sĩ trước khi bắt đầu sử dụng bất kỳ thực phẩm bổ sung nào.Luôn tham khảo ý kiến chuyên gia y tế trước khi sử dụng bất kỳ thực phẩm chức năng nào.

Frequently Asked Questions

Does Calcium help with High Blood Pressure (Hypertension)?

Based on 13 studies with 1,500 participants, there is limited but promising evidence that Calcium may support High Blood Pressure (Hypertension) management. Our evidence grade is C (Some Evidence).

How much Calcium should I take for High Blood Pressure (Hypertension)?

Studies have used various dosages. A commonly studied range is Prefer dietary sources; limit supplements to 500 mg/dose. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Calcium?

Reported side effects may include Constipation (especially carbonate form), Potential increased MI risk with high-dose supplements (controversial), Kidney stones at excessive doses, Gas, bloating. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Calcium and High Blood Pressure (Hypertension)?

We rate the evidence as Grade C (Some Evidence). This rating is based on 13 peer-reviewed studies with 1,500 total participants. The overall direction of effect is mixed.

Các thành phần khác cho High Blood Pressure (Hypertension)

Beetroot Extract A Garlic A Magnesium B Potassium B Quercetin B Grape Seed Extract B

Đánh giá nhanh

Small meta-analytic BP reduction (-1.4 mmHg systolic). Overwhelmed by cardiovascular safety concerns from supplement studies. Dietary calcium preferred.

Evidence Strength52%

Moderate confidence

Phân tích nghiên cứu

RCT (0)Meta (1)Other (12)

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Xem tất cả thành phần cho High Blood Pressure (Hypertension)

Tìm hiểu thêm

References

[1] Takafumi Ushida et al.. Hypertens Res. 2025. Dietary supplements and prevention of preeclampsia. doi:10.1038/s41440-025-02144-9 PubMed
[2] Sasan Amanat et al.. Adv Nutr. 2025. Associations between Diet and Cognitive Function in Stroke Survivors: A Systematic Review and Meta-analysis. doi:10.1016/j.advnut.2025.100440 PubMed
[3] Jerzy Głuszek. Wiad Lek. 2024. Novel pharmacologic approaches in resistant hypertension. doi:10.36740/WLek/194090 PubMed
[4] Giulia Marrone et al.. Nutrients. 2021. Vegan Diet Health Benefits in Metabolic Syndrome. doi:10.3390/nu13030817 PubMed
[5] Niloufar Zadeh Saraji et al.. J Renal Inj Prev. 2017. Restless leg syndrome in chronic hemodialysis patients in Mashhad hemodialysis centers. doi:10.15171/jrip.2017.27 PubMed
[6] Betty S Chan et al.. Clin Toxicol (Phila). 2016. Efficacy and effectiveness of anti-digoxin antibodies in chronic digoxin poisonings from the DORA study (ATOM-1). doi:10.1080/15563650.2016.1175620 PubMed
[7] Alfonso Eirin et al.. Trends Cardiovasc Med. 2016. Emerging concepts for patients with treatment-resistant hypertension. doi:10.1016/j.tcm.2016.05.004 PubMed
[8] Behzad Einollahi et al.. Nephrourol Mon. 2014. Restless leg syndrome: a neglected diagnosis. doi:10.5812/numonthly.22009 PubMed
[9] Jian-hong Li et al.. Zhongguo Zhong Yao Za Zhi. 2014. [Clinical characteristics and combined use of medicine analysis of 2 991 hospitalized patients with psoriasis based on real world database]. PubMed
[10] S Basit. Br J Biomed Sci. 2013. Vitamin D in health and disease: a literature review. doi:10.1080/09674845.2013.11669951 PubMed
[11] Eka Ginanjar et al.. Acta Med Indones. 2007. Vitamin D and autoimmune disease. PubMed

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Calcium cho High Blood Pressure (Hypertension)

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Kết luận

Key Study Findings

Key Statistics

Referenced Papers

Dosage & Usage

Liều lượng thường dùng

Liều lượng đã nghiên cứu

Safety & Side Effects

Tác dụng phụ đã được báo cáo

Tương tác đã biết

Frequently Asked Questions

Related Evidence

Các thành phần khác cho High Blood Pressure (Hypertension)

References