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Magnesium cho High Blood Pressure (Hypertension)

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Meta-analysis of 34 RCTs: systolic -2.0 mmHg, diastolic -1.78 mmHg at 368 mg/day. Greater effects in magnesium-deficient populations. Approximately 50% of US adults consume below the estimated average requirement.

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Kết luận

            
            
Meta-analysis of 34 RCTs: systolic -2.0 mmHg, diastolic -1.78 mmHg at 368 mg/day. Greater effects in magnesium-deficient populations. Approximately 50% of US adults consume below the estimated average requirement.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Review
                
                
                
                
            

            
                Dietary supplements and prevention of preeclampsia.
            
            

                
                Dose: 500 mg daily
                
                
                so với: Placebo
                
                
                Outcome: Preeclampsia risk reduction
                
                
                Hiệu quả: ~50% risk reduction
                
                
                None
                
            

            
            
Đối tượng nghiên cứu: Pregnant women with low calcium intake

            
        

        
        

            

                
                    Case Reports
                
                
                
                13.0 weeks
                
                
            

            
                A case report of Gitelman syndrome in children.
            
            

                
                Dose: 3 g
                
                
                so với: None
                
                
                Outcome: pain reduction
                
                
                Hiệu quả: None
                
                
                None
                
            

            
            
Đối tượng nghiên cứu: Hypokalemia

            
        

        
        

            

                
                    Review
                
                
                
                
            

            
                Nutritional prevention of cognitive decline and dementia.
            
            

                
                Dose: None
                
                
                so với: None
                
                
                Outcome: Cognitive decline prevention
                
                
                Hiệu quả: None
                
                
                None
                
            

            
            
Đối tượng nghiên cứu: Older adults at risk of cognitive decline

            
        

        
        

            

                
                    Systematic Review
                
                
                
                
            

            
                The impact of essential fatty acid, B vitamins, vitamin C, magnesium and zinc supplementation on …
            
            

                
                Dose: varied: EFAs, B vitamins, vitamin C, magnesium, zinc as dietary supplements
                
                
                so với: Placebo
                
                
                
                Hiệu quả: None
                
                
                None
                
            

            
        

        
        

            

                
                    Review
                
                
                
                
            

            
                Prevention of hypokalemia caused by diuretics.
            
            

                
                Dose: None
                
                
                so với: None
                
                
                Outcome: mineral status
                
                
                Hiệu quả: None
                
                
                None
                
            

            
            
Đối tượng nghiên cứu: hypertensive patients

            
        

        
        

            

                
                    Randomized Controlled Trial
                
                
                n=48
                
                
                26.0 weeks
                
                
            

            
                Effects of spironolactone on serum and muscle electrolytes in patients on long-term diuretic therapy for …
            
            

                
                Dose: 100 mg/d
                
                
                so với: control group
                
                
                Outcome: blood pressure
                
                
                Hiệu quả: None
                
                
                None
                
            

            
            
Đối tượng nghiên cứu: hypertensive patients

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
34

        
Nghiên cứu

    

    

        
2028

        
Người tham gia

    

    

        
            
            ↑
            
        
        
Positive

    

    

        B

        
Xếp hạng

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Dietary supplements and prevention of preeclampsia.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Hypertension research : …
                        2025
                        
                        10 trích dẫn
                        
                    

                

                
                

                    

                        
                            A case report of Gitelman syndrome in children.
                        
                        
                            
                                Case Report
                            
                            
                            
                        
                    

                    

                        Medicine
                        2023
                        
                    

                

                
                

                    

                        
                            Nutritional prevention of cognitive decline and dementia.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Acta bio-medica : …
                        2018
                        
                        103 trích dẫn
                        
                    

                

                
                

                    

                        
                            The impact of essential fatty acid, B vitamins, vitamin C, magnesium and zinc supplementation on stress levels in women: a …
                        
                        
                            
                                Systematic Review
                            
                            
                            
                        
                    

                    

                        JBI database of …
                        2017
                        
                        38 trích dẫn
                        
                    

                

                
                

                    

                        
                            Prevention of hypokalemia caused by diuretics.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Heart disease and …
                        1994
                        
                    

                

                
                

                    

                        
                            Effects of spironolactone on serum and muscle electrolytes in patients on long-term diuretic therapy for congestive heart failure and/or arterial …
                        
                        
                            
                                RCT
                            
                            
                            
                        
                    

                    

                        European journal of …
                        1986
                        
                        22 trích dẫn
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Liều lượng thường dùng

                

                    
                    

                        
general:

                        
310-420 mg/day

                    

                    
                    

                        
bloodpressuresupport:

                        
300-500 mg/day

                    

                    
                    

                        
cardiovascularsupport:

                        
300-400 mg/day elemental magnesium

                    

                    
                

                
                

                    Giới hạn trên: 350 mg/day from supplements only (no UL for food magnesium)
                

                
            

            

            
            

                
Liều lượng đã nghiên cứu

                

                    

                        
                            

                                Liều lượng
                                Thời gian
                                Hiệu quả
                                N
                            

                        
                        
                            
                            

                                500 mg daily
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                3 g
                                13.0 weeks
                                
                                    
                                    Mixed
                                    
                                
                                --
                            

                            
                            

                                None
                                --
                                
                                    
                                    Mixed
                                    
                                
                                --
                            

                            
                            

                                varied: EFAs, B vitamins, vitamin C, magnesium, zinc as dietary supplements
                                --
                                
                                    
                                    Mixed
                                    
                                
                                --
                            

                            
                            

                                None
                                --
                                
                                    
                                    Mixed
                                    
                                
                                --
                            

                            
                            

                                100 mg/d
                                26.0 weeks
                                
                                    
                                    Mixed
                                    
                                
                                48
                            

                            
                        
                    

                

            

            

            
            

                Thời điểm dùng tốt nhất: With meals to reduce GI side effects; evening dosing may support sleep
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Tác dụng phụ đã được báo cáo

                    
    
                        
                        
  • 
                            ⚠
                            Diarrhea (especially magnesium oxide and citrate)
                        
    • 
                        
                        
  • 
                            ⚠
                            Nausea
                        
    • 
                        
                        
  • 
                            ⚠
                            Abdominal cramping
                        
    • 
                        
                        
  • 
                            ⚠
                            Excessive doses may cause hypotension or cardiac depression
                        
    • 
                        
                    

                

                

                
                

                    
Tương tác đã biết

                    
    
                        
                        
  • 
                            ●
                            Bisphosphonates (reduced absorption — separate by 2 hours)
                        
    • 
                        
                        
  • 
                            ●
                            Antibiotics (tetracyclines, fluoroquinolones — separate by 2-4 hours)
                        
    • 
                        
                        
  • 
                            ●
                            Diuretics (thiazides reduce, loop diuretics increase magnesium loss)
                        
    • 
                        
                        
  • 
                            ●
                            Proton pump inhibitors (long-term use may cause hypomagnesemia)
                        
    • 
                        
                    

                

                

                
                

                    

                        Mức hấp thụ tối đa cho phép: 350 mg/day from supplements only (no UL for food magnesium)
                    

                

                
            

            

                Luôn tham khảo ý kiến bác sĩ trước khi bắt đầu sử dụng bất kỳ thực phẩm bổ sung nào.Luôn tham khảo ý kiến chuyên gia y tế trước khi sử dụng bất kỳ thực phẩm chức năng nào.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Magnesium help with High Blood Pressure (Hypertension)?
            
        
        

            Based on 34 studies with 2,028 participants, there is moderate evidence from clinical studies that Magnesium may support High Blood Pressure (Hypertension) management. Our evidence grade is B (Good Evidence).
        

    

    
    

        
            How much Magnesium should I take for High Blood Pressure (Hypertension)?
            
        
        

            Studies have used various dosages. A commonly studied range is 310-420 mg/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Magnesium?
            
        
        

            Reported side effects may include Diarrhea (especially magnesium oxide and citrate), Nausea, Abdominal cramping, Excessive doses may cause hypotension or cardiac depression. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Magnesium and High Blood Pressure (Hypertension)?
            
        
        

            We rate the evidence as Grade B (Good Evidence). This rating is based on 34 peer-reviewed studies with 2,028 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  




            

                
                
                

                
                

                    
Magnesium cho các tình trạng khác

                    

                        
                        
                            Cardiac Arrhythmia
                            B

                        
                        
                        
                            Coronary Artery Disease (CAD)
                            C

                        
                        
                    

                

                
            

        

        

    


    
    






  
References

  
    
    
    
  1. 
      [1]
      Takafumi Ushida et al..
      Hypertens Res.
      2025.
      Dietary supplements and prevention of preeclampsia.
      doi:10.1038/s41440-025-02144-9
      PubMed
    
    2. 
    
    
  2. 
      [2]
      Jing Ying et al..
      Medicine (Baltimore).
      2023.
      A case report of Gitelman syndrome in children.
      doi:10.1097/MD.0000000000033509
      PubMed
    
    3. 
    
    
  3. 
      [3]
      Ligia J Dominguez et al..
      Acta Biomed.
      2018.
      Nutritional prevention of cognitive decline and dementia.
      doi:10.23750/abm.v89i2.7401
      PubMed
    
    4. 
    
    
  4. 
      [4]
      Delia McCabe et al..
      JBI Database System Rev Implement Rep.
      2017.
      The impact of essential fatty acid, B vitamins, vitamin C, magnesium and zinc supplementation on stress levels in women: a …
      doi:10.11124/JBISRIR-2016-002965
      PubMed
    
    5. 
    
    
  5. 
      [5]
      E Bourke et al..
      Heart Dis Stroke.
      1994.
      Prevention of hypokalemia caused by diuretics.
      
      PubMed
    
    6. 
    
    
  6. 
      [6]
      T Dyckner et al..
      Eur J Clin Pharmacol.
      1986.
      Effects of spironolactone on serum and muscle electrolytes in patients on long-term diuretic therapy for congestive heart failure and/or arterial …
      doi:10.1007/BF00542411
      PubMed
    
    7. 
    
  















    

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