Vitamin D cho High Blood Pressure (Hypertension)

C Bằng chứng Bằng chứng hạn chế từ các nghiên cứu nhỏ, nhưng có một số tín hiệu tích cực.

Meta-analyses show modest BP reduction (-2-6 mmHg) in deficient populations only. VITAL trial was negative for cardiovascular endpoints. Research suggests benefits may be limited to correcting deficiency.

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Key Study Findings

Observational Study n=2582

Relationship Between Serum Vitamins and Cognitive Impairment in the Elderly: A Study Based on the …

Dose: None so với: None Outcome: Cognitive impairment risk Hiệu quả: OR=0.695 (Vit D); OR=0.777 (FA) p=0.003 (Vit D); p=0.034 (FA)

Đối tượng nghiên cứu: Elderly participants aged 60+ from NHANES 2011-2014

Observational Study n=72

Cardiovascular Risk and Systemic Inflammation in Alopecia Areata: An Observational Case-control Study.

Dose: None so với: Healthy controls Outcome: CVR and systemic inflammation in alopecia areata Hiệu quả: None None

Đối tượng nghiên cứu: 36 AA patients vs 36 matched controls, mean age 39

review

Top studies of 2024 relevant to primary care: From the PEER team.

Dose: None so với: Placebo Hiệu quả: None None

Review

Dietary supplements and prevention of preeclampsia.

Dose: 500 mg daily so với: Placebo Outcome: Preeclampsia risk reduction Hiệu quả: ~50% risk reduction None

Đối tượng nghiên cứu: Pregnant women with low calcium intake

Observational Study n=2065

Cytomegalovirus (CMV), oxidative stress, and inflammation: implications for immunosenescence and age-related diseases in the MARK-AGE …

Dose: None so với: None Outcome: CMV IgG association with oxidative stress markers Hiệu quả: None None

Đối tượng nghiên cứu: Age-stratified general population (MARK-AGE RASIG cohort)

Systematic Review

Interventions for preventing the progression of autosomal dominant polycystic kidney disease.

Dose: Disease-modifying agents (tolvaptan, etc.) so với: Placebo or standard care Outcome: Kidney disease progression Hiệu quả: None None

Đối tượng nghiên cứu: Patients with ADPKD

Key Statistics

Nghiên cứu

30000

Người tham gia

↔

Mixed

Xếp hạng

Referenced Papers

Relationship Between Serum Vitamins and Cognitive Impairment in the Elderly: A Study Based on the NHANES Database. Other

Brain and behavior 2026

Dietary supplements and prevention of preeclampsia. Review

Hypertension research : … 2025 10 trích dẫn

Cytomegalovirus (CMV), oxidative stress, and inflammation: implications for immunosenescence and age-related diseases in the MARK-AGE population. Other

Biogerontology 2025

Top studies of 2024 relevant to primary care: From the PEER team. Review

Canadian family physician … 2025

Cardiovascular Risk and Systemic Inflammation in Alopecia Areata: An Observational Case-control Study. Observational

Acta dermatovenerologica Croatica … 2025

Interventions for preventing the progression of autosomal dominant polycystic kidney disease. Systematic Review

The Cochrane database … 2024 1 trích dẫn

Effects of age and sex on the comorbidities of alopecia areata: A cross-sectional hospital-based study. Other

Health science reports 2023 3 trích dẫn

Observational and Genetic Associations of Modifiable Risk Factors with Aortic Valve Stenosis: A Prospective Cohort Study of 0.5 Million Participants. Observational

Nutrients 2022 14 trích dẫn

Sleep status in multiple sclerosis: Role of vitamin D and body mass index. Other

Current journal of … 2022 11 trích dẫn

Sleep patterns modify the association of 25(OH)D with poor cardiovascular health in pregnant women. Other

Frontiers in nutrition 2022 4 trích dẫn

Vitamin D levels in primary care patients: correlations with clinical, seasonal, and quality-of-life parameters. Other

Family practice 2022 2 trích dẫn

Vegan Diet Health Benefits in Metabolic Syndrome. Review

Nutrients 2021 113 trích dẫn

l-Cysteine Stimulates the Effect of Vitamin D on Inhibition of Oxidative Stress, IL-8, and MCP-1 Secretion in High Glucose Treated … Other

Journal of the … 2021 23 trích dẫn

Potential of Chlorella as a Dietary Supplement to Promote Human Health. Review

Nutrients 2020 219 trích dẫn

Vitamin D deficiency changes the intestinal microbiome reducing B vitamin production in the gut. The resulting lack of pantothenic acid … Other

Medical hypotheses 2016 105 trích dẫn

Nutrient intake, nutritional status, and cognitive function with aging. Review

Annals of the … 2016 89 trích dẫn

Female Pattern Hair Loss: A Retrospective Study in a Tertiary Referral Center. Other

International journal of … 2016 28 trích dẫn

Vitamin D in health and disease: a literature review. Review

British journal of … 2013 156 trích dẫn

Occurrence of milnacipran-associated morbilliform rash and serotonin toxicity. Case Report

The Annals of … 2013

The VITamin D and OmegA-3 TriaL (VITAL): rationale and design of a large randomized controlled trial of vitamin D and … RCT

Contemporary clinical trials 2012 522 trích dẫn

Vitamin D and autoimmune disease. Review

Acta medica Indonesiana 2007 4 trích dẫn

Intensive session: New approaches to medical issues in long-term care. Review

Journal of the … 2007

Sleep behavior disorders in a large cohort of chinese (Taiwanese) patients maintained by long-term hemodialysis. Other

American journal of … 2006

Endometrial effects during hormone replacement therapy with a sequential oestradiol valerate/cyproterone acetate preparation. RCT

Maturitas 1993

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Liều lượng thường dùng

general:: 600-800 IU/day
deficiencycorrection:: 4,000-5,000 IU/day (under medical supervision)
cardiovascularsupport:: 1,000-2,000 IU/day

Giới hạn trên: 4,000 IU/day (100 mcg)

Liều lượng đã nghiên cứu

Liều lượng	Thời gian	Hiệu quả	N
None	--	Positive	2582
None	--	Negative	72
None	--	Mixed	--
500 mg daily	--	Positive	--
None	--	Negative	2065
Disease-modifying agents (tolvaptan, etc.)	--	Positive	--
36%	--	Mixed	--
not applicable	--	Neutral	103

Thời điểm dùng tốt nhất: With a meal containing fat for better absorption

Safety & Side Effects

Tác dụng phụ đã được báo cáo

⚠ Hypercalcemia at very high doses (fatigue, nausea, kidney stones)
⚠ Constipation
⚠ Generally very safe at recommended doses

Tương tác đã biết

● Thiazide diuretics (may increase hypercalcemia risk)
● Statins (theoretical interaction via CYP enzymes)
● Corticosteroids (may reduce vitamin D absorption)
● Weight loss medications (may reduce absorption of fat-soluble vitamins)

Mức hấp thụ tối đa cho phép: 4,000 IU/day (100 mcg)

Luôn tham khảo ý kiến bác sĩ trước khi bắt đầu sử dụng bất kỳ thực phẩm bổ sung nào.Luôn tham khảo ý kiến chuyên gia y tế trước khi sử dụng bất kỳ thực phẩm chức năng nào.

Frequently Asked Questions

Does Vitamin D help with High Blood Pressure (Hypertension)?

Based on 20 studies with 30,000 participants, there is limited but promising evidence that Vitamin D may support High Blood Pressure (Hypertension) management. Our evidence grade is C (Some Evidence).

How much Vitamin D should I take for High Blood Pressure (Hypertension)?

Studies have used various dosages. A commonly studied range is 600-800 IU/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Vitamin D?

Reported side effects may include Hypercalcemia at very high doses (fatigue, nausea, kidney stones), Constipation, Generally very safe at recommended doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Vitamin D and High Blood Pressure (Hypertension)?

We rate the evidence as Grade C (Some Evidence). This rating is based on 20 peer-reviewed studies with 30,000 total participants. The overall direction of effect is mixed.

Các thành phần khác cho High Blood Pressure (Hypertension)

Beetroot Extract A Garlic A Magnesium B Potassium B Quercetin B Grape Seed Extract B

Vitamin D cho các tình trạng khác

Heart Failure C

Đánh giá nhanh

Evidence Strength52%

Moderate confidence

Phân tích nghiên cứu

RCT (2)Meta (0)Other (18)

So sánh lựa chọn thay thế

Xem các thành phần khác so sánh như thế nào cho tình trạng này.

Xem tất cả thành phần cho High Blood Pressure (Hypertension)

Tìm hiểu thêm

References

[1] Jiarui Miao et al.. Brain Behav. 2026. Relationship Between Serum Vitamins and Cognitive Impairment in the Elderly: A Study Based on the NHANES Database. doi:10.1002/brb3.71181 PubMed
[2] Takafumi Ushida et al.. Hypertens Res. 2025. Dietary supplements and prevention of preeclampsia. doi:10.1038/s41440-025-02144-9 PubMed
[3] Laura Cianfruglia et al.. Biogerontology. 2025. Cytomegalovirus (CMV), oxidative stress, and inflammation: implications for immunosenescence and age-related diseases in the MARK-AGE population. doi:10.1007/s10522-025-10288-x PubMed
[4] Samantha S Moe et al.. Can Fam Physician. 2025. Top studies of 2024 relevant to primary care: From the PEER team. doi:10.46747/cfp.7105309 PubMed
[5] Alberto Soto-Moreno et al.. Acta Dermatovenerol Croat. 2025. Cardiovascular Risk and Systemic Inflammation in Alopecia Areata: An Observational Case-control Study. PubMed
[6] Kitty St Pierre et al.. Cochrane Database Syst Rev. 2024. Interventions for preventing the progression of autosomal dominant polycystic kidney disease. doi:10.1002/14651858.CD010294.pub3 PubMed
[7] Elham Hamidpour et al.. Health Sci Rep. 2023. Effects of age and sex on the comorbidities of alopecia areata: A cross-sectional hospital-based study. doi:10.1002/hsr2.1444 PubMed
[8] Ninghao Huang et al.. Nutrients. 2022. Observational and Genetic Associations of Modifiable Risk Factors with Aortic Valve Stenosis: A Prospective Cohort Study of 0.5 Million Participants. doi:10.3390/nu14112273 PubMed
[9] Mohammad Yazdchi et al.. Curr J Neurol. 2022. Sleep status in multiple sclerosis: Role of vitamin D and body mass index. doi:10.18502/cjn.v21i2.10489 PubMed
[10] Wan-Jun Yin et al.. Front Nutr. 2022. Sleep patterns modify the association of 25(OH)D with poor cardiovascular health in pregnant women. doi:10.3389/fnut.2022.1013960 PubMed
[11] Izolde Bouloukaki et al.. Fam Pract. 2022. Vitamin D levels in primary care patients: correlations with clinical, seasonal, and quality-of-life parameters. doi:10.1093/fampra/cmac012 PubMed
[12] Giulia Marrone et al.. Nutrients. 2021. Vegan Diet Health Benefits in Metabolic Syndrome. doi:10.3390/nu13030817 PubMed
[13] Sushil K Jain et al.. J Am Coll Nutr. 2021. l-Cysteine Stimulates the Effect of Vitamin D on Inhibition of Oxidative Stress, IL-8, and MCP-1 Secretion in High Glucose Treated … doi:10.1080/07315724.2020.1850371 PubMed
[14] Tomohiro Bito et al.. Nutrients. 2020. Potential of Chlorella as a Dietary Supplement to Promote Human Health. doi:10.3390/nu12092524 PubMed
[15] S C Gominak. Med Hypotheses. 2016. Vitamin D deficiency changes the intestinal microbiome reducing B vitamin production in the gut. The resulting lack of pantothenic acid … doi:10.1016/j.mehy.2016.07.007 PubMed
[16] Katherine L Tucker. Ann N Y Acad Sci. 2016. Nutrient intake, nutritional status, and cognitive function with aging. doi:10.1111/nyas.13062 PubMed
[17] Tee Wei Siah et al.. Int J Trichology. 2016. Female Pattern Hair Loss: A Retrospective Study in a Tertiary Referral Center. doi:10.4103/0974-7753.188033 PubMed
[18] S Basit. Br J Biomed Sci. 2013. Vitamin D in health and disease: a literature review. doi:10.1080/09674845.2013.11669951 PubMed
[19] Amanda M Huskey et al.. Ann Pharmacother. 2013. Occurrence of milnacipran-associated morbilliform rash and serotonin toxicity. doi:10.1345/aph.1R474 PubMed
[20] Joann E Manson et al.. Contemp Clin Trials. 2012. The VITamin D and OmegA-3 TriaL (VITAL): rationale and design of a large randomized controlled trial of vitamin D and … doi:10.1016/j.cct.2011.09.009 PubMed
[21] Eka Ginanjar et al.. Acta Med Indones. 2007. Vitamin D and autoimmune disease. PubMed
[22] Barbara J Messinger-Rapport et al.. J Am Med Dir Assoc. 2007. Intensive session: New approaches to medical issues in long-term care. doi:10.1016/j.jamda.2007.07.002 PubMed
[23] Wen-Ching Chen et al.. Am J Kidney Dis. 2006. Sleep behavior disorders in a large cohort of chinese (Taiwanese) patients maintained by long-term hemodialysis. doi:10.1053/j.ajkd.2006.04.079 PubMed
[24] P R Koninckx et al.. Maturitas. 1993. Endometrial effects during hormone replacement therapy with a sequential oestradiol valerate/cyproterone acetate preparation. doi:10.1016/0378-5122(93)90054-l PubMed

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