Calcium per High Blood Pressure (Hypertension)

C Evidenze Evidenza limitata da studi di piccole dimensioni, ma esistono alcuni segnali positivi.

Small meta-analytic BP reduction (-1.4 mmHg systolic). Overwhelmed by cardiovascular safety concerns from supplement studies. Dietary calcium preferred.

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In sintesi

Small meta-analytic BP reduction (-1.4 mmHg systolic). Overwhelmed by cardiovascular safety concerns from supplement studies. Dietary calcium preferred.

Key Study Findings

Meta-Analysis

Associations between Diet and Cognitive Function in Stroke Survivors: A Systematic Review and Meta-analysis.

Dose: None vs: Standard care or placebo Outcome: Global cognition in stroke survivors Effetto: SMD=0.62 (energy-protein); SMD=-0.40 (B-vitamins) 0.009 (protein); 0.02 (B-vit)

Popolazione: Adult stroke survivors (20 trials + 14 observational)

Review

Dietary supplements and prevention of preeclampsia.

Dose: 500 mg daily vs: Placebo Outcome: Preeclampsia risk reduction Effetto: ~50% risk reduction None

Popolazione: Pregnant women with low calcium intake

Review

Novel pharmacologic approaches in resistant hypertension.

Dose: Spironolactone, sacubitril/valsartan, SGLT2i vs: None Outcome: Blood pressure control in resistant HTN Effetto: None None

Popolazione: Patients with resistant hypertension

Review

Vegan Diet Health Benefits in Metabolic Syndrome.

Dose: None vs: None Outcome: None Effetto: None None

Popolazione: Adults with metabolic syndrome

cross-sectional observational study n=260

Restless leg syndrome in chronic hemodialysis patients in Mashhad hemodialysis centers.

Dose: None vs: Placebo Effetto: None None

Observational Study n=40

Efficacy and effectiveness of anti-digoxin antibodies in chronic digoxin poisonings from the DORA study (ATOM-1).

Dose: anti-digoxin antibodies (Fab) vs: pre-treatment Outcome: serum digoxin and clinical outcomes Effetto: Fab bound digoxin; no improved clinical outcomes None

Popolazione: Chronic digoxin toxicity patients

Key Statistics

Studi

1500

Partecipanti

↔

Mixed

Grado

Referenced Papers

Dietary supplements and prevention of preeclampsia. Review

Hypertension research : … 2025 10 citazioni

Associations between Diet and Cognitive Function in Stroke Survivors: A Systematic Review and Meta-analysis. Meta-Analysis

Advances in nutrition … 2025 1 citazioni

Novel pharmacologic approaches in resistant hypertension. Review

Wiadomosci lekarskie (Warsaw, … 2024

Vegan Diet Health Benefits in Metabolic Syndrome. Review

Nutrients 2021 113 citazioni

Restless leg syndrome in chronic hemodialysis patients in Mashhad hemodialysis centers. Other

Journal of renal … 2017 26 citazioni

Efficacy and effectiveness of anti-digoxin antibodies in chronic digoxin poisonings from the DORA study (ATOM-1). Observational

Clinical toxicology (Philadelphia, … 2016 25 citazioni

Emerging concepts for patients with treatment-resistant hypertension. Review

Trends in cardiovascular … 2016 19 citazioni

Restless leg syndrome: a neglected diagnosis. Review

Nephro-urology monthly 2014 43 citazioni

[Clinical characteristics and combined use of medicine analysis of 2 991 hospitalized patients with psoriasis based on real world database]. Other

Zhongguo Zhong yao … 2014 4 citazioni

Vitamin D in health and disease: a literature review. Review

British journal of … 2013 156 citazioni

Vitamin D and autoimmune disease. Review

Acta medica Indonesiana 2007 4 citazioni

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosaggi di uso comune

note:: Prefer dietary sources; limit supplements to 500 mg/dose
general:: 1,000-1,200 mg/day from diet plus supplements

Limite massimo: 2,000-2,500 mg/day (total from diet and supplements)

Dosaggi studiati nella ricerca

Dosaggio	Durata	Effetto	N
None	--	Mixed	--
500 mg daily	--	Positive	--
Spironolactone, sacubitril/valsartan, SGLT2i	--	Positive	--
None	--	Mixed	--
None	--	Neutral	260
anti-digoxin antibodies (Fab)	--	Neutral	40
None	--	Mixed	--
None	--	Neutral	2991

Momento migliore per l'assunzione: Divide doses (500 mg max per dose); carbonate with meals; citrate any time

Safety & Side Effects

Effetti collaterali segnalati

⚠ Constipation (especially carbonate form)
⚠ Potential increased MI risk with high-dose supplements (controversial)
⚠ Kidney stones at excessive doses
⚠ Gas, bloating

Interazioni note

● Thyroid medications (separate by 4 hours)
● Bisphosphonates (separate by 30-60 minutes)
● Iron supplements (reduced absorption — separate by 2 hours)
● Certain antibiotics (reduced absorption)
● Vitamin K2 (may help direct supplemental calcium to bones, not arteries)

Livello di assunzione massimo tollerabile: 2,000-2,500 mg/day (total from diet and supplements)

Consultare sempre il proprio medico prima di iniziare qualsiasi integratore.Consultate sempre il vostro medico prima di iniziare qualsiasi integratore.

Frequently Asked Questions

Does Calcium help with High Blood Pressure (Hypertension)?

Based on 13 studies with 1,500 participants, there is limited but promising evidence that Calcium may support High Blood Pressure (Hypertension) management. Our evidence grade is C (Some Evidence).

How much Calcium should I take for High Blood Pressure (Hypertension)?

Studies have used various dosages. A commonly studied range is Prefer dietary sources; limit supplements to 500 mg/dose. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Calcium?

Reported side effects may include Constipation (especially carbonate form), Potential increased MI risk with high-dose supplements (controversial), Kidney stones at excessive doses, Gas, bloating. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Calcium and High Blood Pressure (Hypertension)?

We rate the evidence as Grade C (Some Evidence). This rating is based on 13 peer-reviewed studies with 1,500 total participants. The overall direction of effect is mixed.

Altri ingredienti per High Blood Pressure (Hypertension)

Beetroot Extract A Garlic A Magnesium B Potassium B Quercetin B Grape Seed Extract B

Verdetto rapido

Small meta-analytic BP reduction (-1.4 mmHg systolic). Overwhelmed by cardiovascular safety concerns from supplement studies. Dietary calcium preferred.

Evidence Strength52%

Moderate confidence

Analisi degli studi

RCT (0)Meta (1)Other (12)

Confronta le alternative

Scoprite come si confrontano altri ingredienti per questa condizione.

Visualizza tutti gli ingredienti per High Blood Pressure (Hypertension)

Approfondimenti

References

[1] Takafumi Ushida et al.. Hypertens Res. 2025. Dietary supplements and prevention of preeclampsia. doi:10.1038/s41440-025-02144-9 PubMed
[2] Sasan Amanat et al.. Adv Nutr. 2025. Associations between Diet and Cognitive Function in Stroke Survivors: A Systematic Review and Meta-analysis. doi:10.1016/j.advnut.2025.100440 PubMed
[3] Jerzy Głuszek. Wiad Lek. 2024. Novel pharmacologic approaches in resistant hypertension. doi:10.36740/WLek/194090 PubMed
[4] Giulia Marrone et al.. Nutrients. 2021. Vegan Diet Health Benefits in Metabolic Syndrome. doi:10.3390/nu13030817 PubMed
[5] Niloufar Zadeh Saraji et al.. J Renal Inj Prev. 2017. Restless leg syndrome in chronic hemodialysis patients in Mashhad hemodialysis centers. doi:10.15171/jrip.2017.27 PubMed
[6] Betty S Chan et al.. Clin Toxicol (Phila). 2016. Efficacy and effectiveness of anti-digoxin antibodies in chronic digoxin poisonings from the DORA study (ATOM-1). doi:10.1080/15563650.2016.1175620 PubMed
[7] Alfonso Eirin et al.. Trends Cardiovasc Med. 2016. Emerging concepts for patients with treatment-resistant hypertension. doi:10.1016/j.tcm.2016.05.004 PubMed
[8] Behzad Einollahi et al.. Nephrourol Mon. 2014. Restless leg syndrome: a neglected diagnosis. doi:10.5812/numonthly.22009 PubMed
[9] Jian-hong Li et al.. Zhongguo Zhong Yao Za Zhi. 2014. [Clinical characteristics and combined use of medicine analysis of 2 991 hospitalized patients with psoriasis based on real world database]. PubMed
[10] S Basit. Br J Biomed Sci. 2013. Vitamin D in health and disease: a literature review. doi:10.1080/09674845.2013.11669951 PubMed
[11] Eka Ginanjar et al.. Acta Med Indones. 2007. Vitamin D and autoimmune disease. PubMed

Avvertenza FDA: Queste affermazioni non sono state valutate dalla Food and Drug Administration. I prodotti e le informazioni presenti su questo sito web non sono destinati a diagnosticare, trattare, curare o prevenire alcuna malattia. I gradi di evidenza presentati si basano sulla nostra analisi della ricerca pubblicata e sottoposta a revisione paritaria e non costituiscono consulenza medica. Consultate sempre il vostro medico prima di iniziare qualsiasi regime di integrazione.

Calcium per High Blood Pressure (Hypertension)

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In sintesi

Key Study Findings

Key Statistics

Referenced Papers

Dosage & Usage

Dosaggi di uso comune

Dosaggi studiati nella ricerca

Safety & Side Effects

Effetti collaterali segnalati

Interazioni note

Frequently Asked Questions

Related Evidence

Altri ingredienti per High Blood Pressure (Hypertension)

References