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L-Citrulline per High Blood Pressure (Hypertension)

C Evidenze Evidenza limitata da studi di piccole dimensioni, ma esistono alcuni segnali positivi.

Systolic -4.1 mmHg in meta-analysis. May have superior pharmacokinetics vs. arginine for sustained nitric oxide production. Growing evidence base but still smaller than other BP-lowering supplements.

C

In sintesi

Systolic -4.1 mmHg in meta-analysis. May have superior pharmacokinetics vs. arginine for sustained nitric oxide production. Growing evidence base but still smaller than other BP-lowering supplements.

Key Statistics

7

Studi

400

Partecipanti

↑

Positive

C

Grado

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosaggi di uso comune

lcitrulline:
3,000-6,000 mg/day
citrullinemalate:
6,000-8,000 mg/day
bloodpressuresupport:
3,000 mg/day

Limite massimo: Not formally established; well-tolerated up to 15,000 mg/day in clinical trials

Momento migliore per l'assunzione: On empty stomach; divide doses for sustained arginine elevation

Safety & Side Effects

Effetti collaterali segnalati

  • ⚠ Generally well-tolerated
  • ⚠ Mild gastrointestinal discomfort at high doses
  • ⚠ Heartburn (rare)

Interazioni note

  • ● Antihypertensives (additive blood pressure lowering)
  • ● PDE5 inhibitors (excessive vasodilation risk)
  • ● Nitrates (excessive vasodilation risk)

Livello di assunzione massimo tollerabile: Not formally established; well-tolerated up to 15,000 mg/day in clinical trials

Consultare sempre il proprio medico prima di iniziare qualsiasi integratore.Consultate sempre il vostro medico prima di iniziare qualsiasi integratore.

Frequently Asked Questions

Does L-Citrulline help with High Blood Pressure (Hypertension)?
Based on 7 studies with 400 participants, there is limited but promising evidence that L-Citrulline may support High Blood Pressure (Hypertension) management. Our evidence grade is C (Some Evidence).
How much L-Citrulline should I take for High Blood Pressure (Hypertension)?
Studies have used various dosages. A commonly studied range is 3,000-6,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of L-Citrulline?
Reported side effects may include Generally well-tolerated, Mild gastrointestinal discomfort at high doses, Heartburn (rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for L-Citrulline and High Blood Pressure (Hypertension)?
We rate the evidence as Grade C (Some Evidence). This rating is based on 7 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.

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        Avvertenza FDA:
        Queste affermazioni non sono state valutate dalla Food and Drug Administration. I prodotti e le informazioni presenti su questo sito web non sono destinati a diagnosticare, trattare, curare o prevenire alcuna malattia. I gradi di evidenza presentati si basano sulla nostra analisi della ricerca pubblicata e sottoposta a revisione paritaria e non costituiscono consulenza medica. Consultate sempre il vostro medico prima di iniziare qualsiasi regime di integrazione.