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L-Citrulline per High Blood Pressure (Hypertension)

C

Systolic -4.1 mmHg in meta-analysis. May have superior pharmacokinetics vs. arginine for sustained nitric oxide production. Growing evidence base but still smaller than other BP-lowering supplements.

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            C

        

        

            
In sintesi

            
            
Systolic -4.1 mmHg in meta-analysis. May have superior pharmacokinetics vs. arginine for sustained nitric oxide production. Growing evidence base but still smaller than other BP-lowering supplements.

            
            
        

    











    
    

        
        

            

  
Key Statistics





            


    

        
7

        
Studi

    

    

        
400

        
Partecipanti

    

    

        
            
            ↑
            
        
        
Positive

    

    

        C

        
Grado

    




        


        
        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Dosaggi di uso comune

                

                    
                    

                        
lcitrulline:

                        
3,000-6,000 mg/day

                    

                    
                    

                        
citrullinemalate:

                        
6,000-8,000 mg/day

                    

                    
                    

                        
bloodpressuresupport:

                        
3,000 mg/day

                    

                    
                

                
                

                    Limite massimo: Not formally established; well-tolerated up to 15,000 mg/day in clinical trials
                

                
            

            

            

            
            

                Momento migliore per l'assunzione: On empty stomach; divide doses for sustained arginine elevation
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Effetti collaterali segnalati

                    
    
                        
                        
  • 
                            ⚠
                            Generally well-tolerated
                        
    • 
                        
                        
  • 
                            ⚠
                            Mild gastrointestinal discomfort at high doses
                        
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  • 
                            ⚠
                            Heartburn (rare)
                        
    • 
                        
                    

                

                

                
                

                    
Interazioni note

                    
    
                        
                        
  • 
                            ●
                            Antihypertensives (additive blood pressure lowering)
                        
    • 
                        
                        
  • 
                            ●
                            PDE5 inhibitors (excessive vasodilation risk)
                        
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  • 
                            ●
                            Nitrates (excessive vasodilation risk)
                        
    • 
                        
                    

                

                

                
                

                    

                        Livello di assunzione massimo tollerabile: Not formally established; well-tolerated up to 15,000 mg/day in clinical trials
                    

                

                
            

            

                Consultare sempre il proprio medico prima di iniziare qualsiasi integratore.Consultate sempre il vostro medico prima di iniziare qualsiasi integratore.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does L-Citrulline help with High Blood Pressure (Hypertension)?
            
        
        

            Based on 7 studies with 400 participants, there is limited but promising evidence that L-Citrulline may support High Blood Pressure (Hypertension) management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much L-Citrulline should I take for High Blood Pressure (Hypertension)?
            
        
        

            Studies have used various dosages. A commonly studied range is 3,000-6,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of L-Citrulline?
            
        
        

            Reported side effects may include Generally well-tolerated, Mild gastrointestinal discomfort at high doses, Heartburn (rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for L-Citrulline and High Blood Pressure (Hypertension)?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 7 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  
Related Evidence





            

                
                
                

                
            

        

        

    


    
    












    

        Avvertenza FDA:
        Queste affermazioni non sono state valutate dalla Food and Drug Administration. I prodotti e le informazioni presenti su questo sito web non sono destinati a diagnosticare, trattare, curare o prevenire alcuna malattia. I gradi di evidenza presentati si basano sulla nostra analisi della ricerca pubblicata e sottoposta a revisione paritaria e non costituiscono consulenza medica. Consultate sempre il vostro medico prima di iniziare qualsiasi regime di integrazione.