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L-Citrulline 用于 High Blood Pressure (Hypertension)

C

Systolic -4.1 mmHg in meta-analysis. May have superior pharmacokinetics vs. arginine for sustained nitric oxide production. Growing evidence base but still smaller than other BP-lowering supplements.

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            C

        

        

            
结论

            
            
Systolic -4.1 mmHg in meta-analysis. May have superior pharmacokinetics vs. arginine for sustained nitric oxide production. Growing evidence base but still smaller than other BP-lowering supplements.

            
            
        

    











    
    

        
        

            

  
Key Statistics





            


    

        
7

        
研究数量

    

    

        
400

        
受试者

    

    

        
            
            ↑
            
        
        
Positive

    

    

        C

        
等级

    




        


        
        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
常用剂量

                

                    
                    

                        
lcitrulline:

                        
3,000-6,000 mg/day

                    

                    
                    

                        
citrullinemalate:

                        
6,000-8,000 mg/day

                    

                    
                    

                        
bloodpressuresupport:

                        
3,000 mg/day

                    

                    
                

                
                

                    上限： Not formally established; well-tolerated up to 15,000 mg/day in clinical trials
                

                
            

            

            

            
            

                最佳服用时间： On empty stomach; divide doses for sustained arginine elevation
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
已报告的副作用

                    
    
                        
                        
  • 
                            ⚠
                            Generally well-tolerated
                        
    • 
                        
                        
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                            ⚠
                            Mild gastrointestinal discomfort at high doses
                        
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  • 
                            ⚠
                            Heartburn (rare)
                        
    • 
                        
                    

                

                

                
                

                    
已知相互作用

                    
    
                        
                        
  • 
                            ●
                            Antihypertensives (additive blood pressure lowering)
                        
    • 
                        
                        
  • 
                            ●
                            PDE5 inhibitors (excessive vasodilation risk)
                        
    • 
                        
                        
  • 
                            ●
                            Nitrates (excessive vasodilation risk)
                        
    • 
                        
                    

                

                

                
                

                    

                        可耐受最高摄入量： Not formally established; well-tolerated up to 15,000 mg/day in clinical trials
                    

                

                
            

            

                在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does L-Citrulline help with High Blood Pressure (Hypertension)?
            
        
        

            Based on 7 studies with 400 participants, there is limited but promising evidence that L-Citrulline may support High Blood Pressure (Hypertension) management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much L-Citrulline should I take for High Blood Pressure (Hypertension)?
            
        
        

            Studies have used various dosages. A commonly studied range is 3,000-6,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of L-Citrulline?
            
        
        

            Reported side effects may include Generally well-tolerated, Mild gastrointestinal discomfort at high doses, Heartburn (rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for L-Citrulline and High Blood Pressure (Hypertension)?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 7 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  
Related Evidence





            

                
                
                

                
            

        

        

    


    
    












    

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