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Lycopene لـ Atherosclerosis

D الأبحاث توجد أبحاث أولية فحسب (دراسات مختبرية، تقارير حالات).

EURAMIC study showed association between adipose lycopene and lower MI risk. Cambridge study improved FMD in CAD patients. Interventional evidence is limited.

D

الخلاصة

EURAMIC study showed association between adipose lycopene and lower MI risk. Cambridge study improved FMD in CAD patients. Interventional evidence is limited.

Key Study Findings

Other
Functional food lycopene mitigates obesity-related cognitive decline via lipid metabolism regulation and neuroprotection via taurine …
Dose: 50 mg/kg lycopene in mice مقابل: HFD control mice Outcome: Cognitive function (Y-maze, MWM, novel object recognition)

المجتمع المدروس: HFD-induced obese male C57BL/6 mice

Key Statistics

3

الدراسات

200

المشاركون

↑

Positive

D

التقييم

Referenced Papers

Anti-Inflammatory Actions of Plant-Derived Compounds and Prevention of Chronic Diseases: From Molecular Mechanisms to Applications. Review
International journal of … 2025 32 اقتباسات
Functional food lycopene mitigates obesity-related cognitive decline via lipid metabolism regulation and neuroprotection via taurine and glutathione pathway. Other
Clinical nutrition (Edinburgh, … 2025 1 اقتباسات
Vascular Roads to a Healthier Brain: Lutein Moderates the Influence of Arterial Stiffness on Cognitive Function. Other
The Journal of … 2025
A systematic review on the impact of nutrition and possible supplementation on the deficiency of vitamin complexes, iron, omega-3-fatty acids, … Systematic Review
Archives of gynecology … 2024 18 اقتباسات
Carotenoid Supplementation for Alleviating the Symptoms of Alzheimer's Disease. Review
International journal of … 2024 11 اقتباسات
Antioxidant Lipid Supplement on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis. Meta-Analysis
Nutrients 2024 6 اقتباسات
Sleep symptoms associated with intake of specific dietary nutrients. Other
Journal of sleep … 2014 236 اقتباسات
Carotenoids and cardiovascular disease. Review
Current atherosclerosis reports 2009 122 اقتباسات

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

الجرعات الشائعة

general:
6-15 mg/day
cardiovascularsupport:
15-30 mg/day

الحد الأعلى: Not formally established; up to 75 mg/day used in clinical trials

الجرعات المدروسة في الأبحاث

الجرعة المدة التأثير ن
50 mg/kg lycopene in mice -- Positive --

أفضل وقت للتناول: With meals containing fat (cooking with olive oil enhances absorption 2-3x)

Safety & Side Effects

الآثار الجانبية المُبلّغ عنها

  • ⚠ Generally well-tolerated
  • ⚠ Lycopenodermia (orange skin discoloration) at very high intake — harmless and reversible

التفاعلات المعروفة

  • ● Blood pressure medications (may have mild additive effect)
  • ● Beta-carotene (may compete for absorption)

الحد الأقصى المسموح به: Not formally established; up to 75 mg/day used in clinical trials

استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.

Frequently Asked Questions

Does Lycopene help with Atherosclerosis?
Based on 3 studies with 200 participants, there is preliminary evidence that needs more research that Lycopene may support Atherosclerosis management. Our evidence grade is D (Very Early Research).
How much Lycopene should I take for Atherosclerosis?
Studies have used various dosages. A commonly studied range is 6-15 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Lycopene?
Reported side effects may include Generally well-tolerated, Lycopenodermia (orange skin discoloration) at very high intake — harmless and reversible. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Lycopene and Atherosclerosis?
We rate the evidence as Grade D (Very Early Research). This rating is based on 3 peer-reviewed studies with 200 total participants. The overall direction of effect is positive.

Lycopene لحالات أخرى

High Blood Pressure (Hypertension) B

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References

  
    
    
    
  1. 
      [1]
      Kazuhiko Nakadate et al..
      Int J Mol Sci.
      2025.
      Anti-Inflammatory Actions of Plant-Derived Compounds and Prevention of Chronic Diseases: From Molecular Mechanisms to Applications.
      doi:10.3390/ijms26115206
      PubMed
    
    2. 
    
    
  2. 
      [2]
      Yuqing Wu et al..
      Clin Nutr.
      2025.
      Functional food lycopene mitigates obesity-related cognitive decline via lipid metabolism regulation and neuroprotection via taurine and glutathione pathway.
      doi:10.1016/j.clnu.2025.06.005
      PubMed
    
    3. 
    
    
  3. 
      [3]
      Shreya Verma et al..
      J Nutr.
      2025.
      Vascular Roads to a Healthier Brain: Lutein Moderates the Influence of Arterial Stiffness on Cognitive Function.
      doi:10.1016/j.tjnut.2025.08.029
      PubMed
    
    4. 
    
    
  4. 
      [4]
      Friederike Wylenzek et al..
      Arch Gynecol Obstet.
      2024.
      A systematic review on the impact of nutrition and possible supplementation on the deficiency of vitamin complexes, iron, omega-3-fatty acids, …
      doi:10.1007/s00404-024-07555-6
      PubMed
    
    5. 
    
    
  5. 
      [5]
      Jolanta Flieger et al..
      Int J Mol Sci.
      2024.
      Carotenoid Supplementation for Alleviating the Symptoms of Alzheimer's Disease.
      doi:10.3390/ijms25168982
      PubMed
    
    6. 
    
    
  6. 
      [6]
      Sitong Wan et al..
      Nutrients.
      2024.
      Antioxidant Lipid Supplement on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis.
      doi:10.3390/nu16142213
      PubMed
    
    7. 
    
    
  7. 
      [7]
      Michael A Grandner et al..
      J Sleep Res.
      2014.
      Sleep symptoms associated with intake of specific dietary nutrients.
      doi:10.1111/jsr.12084
      PubMed
    
    8. 
    
    
  8. 
      [8]
      Graziano Riccioni.
      Curr Atheroscler Rep.
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      doi:10.1007/s11883-009-0065-z
      PubMed
    
    9. 
    
  















    

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