Lycopene لـ Atherosclerosis

D الأبحاث توجد أبحاث أولية فحسب (دراسات مختبرية، تقارير حالات).

EURAMIC study showed association between adipose lycopene and lower MI risk. Cambridge study improved FMD in CAD patients. Interventional evidence is limited.

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الخلاصة

EURAMIC study showed association between adipose lycopene and lower MI risk. Cambridge study improved FMD in CAD patients. Interventional evidence is limited.

Key Study Findings

Other

Functional food lycopene mitigates obesity-related cognitive decline via lipid metabolism regulation and neuroprotection via taurine …

Dose: 50 mg/kg lycopene in mice مقابل: HFD control mice Outcome: Cognitive function (Y-maze, MWM, novel object recognition) التأثير: None None

المجتمع المدروس: HFD-induced obese male C57BL/6 mice

Review

Anti-Inflammatory Actions of Plant-Derived Compounds and Prevention of Chronic Diseases: From Molecular Mechanisms to Applications.

Dose: None مقابل: None Outcome: None التأثير: None None

المجتمع المدروس: review of plant-derived anti-inflammatory compounds for chronic disease prevention

Observational Study n=60

Vascular Roads to a Healthier Brain: Lutein Moderates the Influence of Arterial Stiffness on Cognitive …

Dose: None مقابل: None Outcome: Carotenoid moderation of cfPWV-cognition relationship التأثير: Beta=0.53, p=0.04 for lutein moderation 0.02

المجتمع المدروس: Adults, mean age 38.6, 70% female

Meta-Analysis

Antioxidant Lipid Supplement on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis.

Dose: None مقابل: Placebo Outcome: Blood pressure التأثير: None None

المجتمع المدروس: None

systematic review n=90

A systematic review on the impact of nutrition and possible supplementation on the deficiency of …

Dose: None مقابل: Placebo التأثير: None None

Randomized Controlled Trial

Carotenoid Supplementation for Alleviating the Symptoms of Alzheimer's Disease.

Dose: None مقابل: None Outcome: Cognitive decline التأثير: None None

المجتمع المدروس: Alzheimer's disease patients

Key Statistics

الدراسات

200

المشاركون

↑

Positive

التقييم

Referenced Papers

Anti-Inflammatory Actions of Plant-Derived Compounds and Prevention of Chronic Diseases: From Molecular Mechanisms to Applications. Review

International journal of … 2025 32 اقتباسات

Functional food lycopene mitigates obesity-related cognitive decline via lipid metabolism regulation and neuroprotection via taurine and glutathione pathway. Other

Clinical nutrition (Edinburgh, … 2025 1 اقتباسات

Vascular Roads to a Healthier Brain: Lutein Moderates the Influence of Arterial Stiffness on Cognitive Function. Other

The Journal of … 2025

A systematic review on the impact of nutrition and possible supplementation on the deficiency of vitamin complexes, iron, omega-3-fatty acids, … Systematic Review

Archives of gynecology … 2024 18 اقتباسات

Carotenoid Supplementation for Alleviating the Symptoms of Alzheimer's Disease. Review

International journal of … 2024 11 اقتباسات

Antioxidant Lipid Supplement on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis. Meta-Analysis

Nutrients 2024 6 اقتباسات

Sleep symptoms associated with intake of specific dietary nutrients. Other

Journal of sleep … 2014 236 اقتباسات

Carotenoids and cardiovascular disease. Review

Current atherosclerosis reports 2009 122 اقتباسات

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

الجرعات الشائعة

general:: 6-15 mg/day
cardiovascularsupport:: 15-30 mg/day

الحد الأعلى: Not formally established; up to 75 mg/day used in clinical trials

الجرعات المدروسة في الأبحاث

الجرعة	المدة	التأثير	ن
50 mg/kg lycopene in mice	--	Positive	--
None	--	Positive	--
None	--	Positive	60
None	--	Neutral	--
None	--	Negative	90
None	--	Positive	--
None	--	Mixed	--

أفضل وقت للتناول: With meals containing fat (cooking with olive oil enhances absorption 2-3x)

Safety & Side Effects

الآثار الجانبية المُبلّغ عنها

⚠ Generally well-tolerated
⚠ Lycopenodermia (orange skin discoloration) at very high intake — harmless and reversible

التفاعلات المعروفة

● Blood pressure medications (may have mild additive effect)
● Beta-carotene (may compete for absorption)

الحد الأقصى المسموح به: Not formally established; up to 75 mg/day used in clinical trials

استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.

Frequently Asked Questions

Does Lycopene help with Atherosclerosis?

Based on 3 studies with 200 participants, there is preliminary evidence that needs more research that Lycopene may support Atherosclerosis management. Our evidence grade is D (Very Early Research).

How much Lycopene should I take for Atherosclerosis?

Studies have used various dosages. A commonly studied range is 6-15 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Lycopene?

Reported side effects may include Generally well-tolerated, Lycopenodermia (orange skin discoloration) at very high intake — harmless and reversible. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Lycopene and Atherosclerosis?

We rate the evidence as Grade D (Very Early Research). This rating is based on 3 peer-reviewed studies with 200 total participants. The overall direction of effect is positive.

مكونات أخرى لـ Atherosclerosis

Nattokinase B Vitamin E C Resveratrol C Quercetin D Flaxseed Oil D Olive Leaf Extract D

Lycopene لحالات أخرى

High Blood Pressure (Hypertension) B

الخلاصة السريعة

EURAMIC study showed association between adipose lycopene and lower MI risk. Cambridge study improved FMD in CAD patients. Interventional evidence is limited.

Evidence Strength30%

Low confidence

تفصيل الدراسات

RCT (0)Meta (1)Other (2)

قارن البدائل

اعرف كيف تقارن المكونات الأخرى لهذه الحالة.

عرض جميع المكونات لـ Atherosclerosis

اعرف المزيد

References

[1] Kazuhiko Nakadate et al.. Int J Mol Sci. 2025. Anti-Inflammatory Actions of Plant-Derived Compounds and Prevention of Chronic Diseases: From Molecular Mechanisms to Applications. doi:10.3390/ijms26115206 PubMed
[2] Yuqing Wu et al.. Clin Nutr. 2025. Functional food lycopene mitigates obesity-related cognitive decline via lipid metabolism regulation and neuroprotection via taurine and glutathione pathway. doi:10.1016/j.clnu.2025.06.005 PubMed
[3] Shreya Verma et al.. J Nutr. 2025. Vascular Roads to a Healthier Brain: Lutein Moderates the Influence of Arterial Stiffness on Cognitive Function. doi:10.1016/j.tjnut.2025.08.029 PubMed
[4] Friederike Wylenzek et al.. Arch Gynecol Obstet. 2024. A systematic review on the impact of nutrition and possible supplementation on the deficiency of vitamin complexes, iron, omega-3-fatty acids, … doi:10.1007/s00404-024-07555-6 PubMed
[5] Jolanta Flieger et al.. Int J Mol Sci. 2024. Carotenoid Supplementation for Alleviating the Symptoms of Alzheimer's Disease. doi:10.3390/ijms25168982 PubMed
[6] Sitong Wan et al.. Nutrients. 2024. Antioxidant Lipid Supplement on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis. doi:10.3390/nu16142213 PubMed
[7] Michael A Grandner et al.. J Sleep Res. 2014. Sleep symptoms associated with intake of specific dietary nutrients. doi:10.1111/jsr.12084 PubMed
[8] Graziano Riccioni. Curr Atheroscler Rep. 2009. Carotenoids and cardiovascular disease. doi:10.1007/s11883-009-0065-z PubMed

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Lycopene لـ Atherosclerosis

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الخلاصة

Key Study Findings

Key Statistics

Referenced Papers

Dosage & Usage

الجرعات الشائعة

الجرعات المدروسة في الأبحاث

Safety & Side Effects

الآثار الجانبية المُبلّغ عنها

التفاعلات المعروفة

Frequently Asked Questions

Related Evidence

مكونات أخرى لـ Atherosclerosis

Lycopene لحالات أخرى

References