Vitamin E لـ Atherosclerosis

C الأدلة أدلة محدودة من دراسات صغيرة، غير أن ثمة بعض الإشارات الإيجابية.

Strong mechanistic rationale (LDL oxidation inhibition) but large RCTs (HOPE, GISSI-Prevenzione) show no benefit. Meta-analysis suggests potential harm at >=400 IU/day. AHA does not recommend supplementation.

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الخلاصة

Key Study Findings

Review

Navigating the Effects of Anti-Atherosclerotic Supplements and Acknowledging Associated Bleeding Risks.

Dose: None مقابل: None Outcome: None التأثير: None None

المجتمع المدروس: Review of anti-atherosclerotic supplements and bleeding

Other

Extensive Bioactivity of Astaxanthin from Haematococcus pluvialis in Human.

Dose: None مقابل: None Outcome: None التأثير: None None

المجتمع المدروس: None

Other

Supplementation with Resveratrol, Piperine and Alpha-Tocopherol Decreases Chronic Inflammation in a Cluster of Older Adults …

Dose: None مقابل: Conventional treatment Outcome: effect of a dietary supplement on chronic inflammation … التأثير: None p < 0.05

المجتمع المدروس: None

Review

Nutrient intake, nutritional status, and cognitive function with aging.

Dose: None مقابل: None Outcome: None التأثير: None None

المجتمع المدروس: Aging adults (nutrition and cognition)

Review

Role of reactive oxygen species and antioxidants in atopic dermatitis.

Dose: None مقابل: None Outcome: Role of oxidative stress in atopic dermatitis التأثير: None None

المجتمع المدروس: Patients with atopic dermatitis

Review

Astaxanthin: a novel potential treatment for oxidative stress and inflammation in cardiovascular disease.

Dose: None مقابل: None Outcome: Astaxanthin: a novel potential treatment for oxidative stress … التأثير: None None

المجتمع المدروس: None

Key Statistics

الدراسات

50000

المشاركون

↔

Mixed

التقييم

Referenced Papers

Navigating the Effects of Anti-Atherosclerotic Supplements and Acknowledging Associated Bleeding Risks. Review

International journal of … 2025 1 اقتباسات

Extensive Bioactivity of Astaxanthin from Haematococcus pluvialis in Human. Other

Advances in experimental … 2021 13 اقتباسات

Supplementation with Resveratrol, Piperine and Alpha-Tocopherol Decreases Chronic Inflammation in a Cluster of Older Adults with Metabolic Syndrome. Other

Nutrients 2020 16 اقتباسات

Nutrient intake, nutritional status, and cognitive function with aging. Review

Annals of the … 2016 89 اقتباسات

Role of reactive oxygen species and antioxidants in atopic dermatitis. Other

Journal of clinical … 2013 178 اقتباسات

Astaxanthin: a novel potential treatment for oxidative stress and inflammation in cardiovascular disease. Review

The American journal … 2008 441 اقتباسات

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

الجرعات الشائعة

note:: High-dose supplementation no longer recommended based on clinical trial evidence
general:: 15 mg/day (22.4 IU)

الحد الأعلى: 1,000 mg/day (1,500 IU natural, 1,100 IU synthetic)

الجرعات المدروسة في الأبحاث

الجرعة	المدة	التأثير	ن
None	--	Mixed	--
None	--	Positive	--
None	--	Mixed	--
None	--	Mixed	--
None	--	Positive	--
None	--	Positive	--

أفضل وقت للتناول: With meals containing fat

Safety & Side Effects

الآثار الجانبية المُبلّغ عنها

⚠ Increased bleeding risk at high doses
⚠ Possible increased all-cause mortality at >=400 IU/day
⚠ Increased heart failure hospitalization risk (HOPE/HOPE-TOO)
⚠ Nausea, diarrhea, fatigue at high doses

التفاعلات المعروفة

● Anticoagulants (increased bleeding risk)
● Statins and niacin (may blunt HDL-raising effect)
● Chemotherapy and radiation (theoretical interference with oxidative mechanisms)
● Vitamin K (may antagonize at high doses)

الحد الأقصى المسموح به: 1,000 mg/day (1,500 IU natural, 1,100 IU synthetic)

استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.

Frequently Asked Questions

Does Vitamin E help with Atherosclerosis?

Based on 15 studies with 50,000 participants, there is limited but promising evidence that Vitamin E may support Atherosclerosis management. Our evidence grade is C (Some Evidence).

How much Vitamin E should I take for Atherosclerosis?

Studies have used various dosages. A commonly studied range is High-dose supplementation no longer recommended based on clinical trial evidence. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Vitamin E?

Reported side effects may include Increased bleeding risk at high doses, Possible increased all-cause mortality at >=400 IU/day, Increased heart failure hospitalization risk (HOPE/HOPE-TOO), Nausea, diarrhea, fatigue at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Vitamin E and Atherosclerosis?

We rate the evidence as Grade C (Some Evidence). This rating is based on 15 peer-reviewed studies with 50,000 total participants. The overall direction of effect is mixed.

مكونات أخرى لـ Atherosclerosis

Nattokinase B Resveratrol C Lycopene D Quercetin D Flaxseed Oil D Olive Leaf Extract D

الخلاصة السريعة

Evidence Strength52%

Moderate confidence

تفصيل الدراسات

RCT (0)Meta (0)Other (15)

قارن البدائل

اعرف كيف تقارن المكونات الأخرى لهذه الحالة.

عرض جميع المكونات لـ Atherosclerosis

اعرف المزيد

References

[1] Maria-Zinaida Dobre et al.. Int J Mol Sci. 2025. Navigating the Effects of Anti-Atherosclerotic Supplements and Acknowledging Associated Bleeding Risks. doi:10.3390/ijms262010183 PubMed
[2] Eiji Yamashita. Adv Exp Med Biol. 2021. Extensive Bioactivity of Astaxanthin from Haematococcus pluvialis in Human. doi:10.1007/978-981-15-7360-6_23 PubMed
[3] Raúl Francisco Pastor et al.. Nutrients. 2020. Supplementation with Resveratrol, Piperine and Alpha-Tocopherol Decreases Chronic Inflammation in a Cluster of Older Adults with Metabolic Syndrome. doi:10.3390/nu12103149 PubMed
[4] Katherine L Tucker. Ann N Y Acad Sci. 2016. Nutrient intake, nutritional status, and cognitive function with aging. doi:10.1111/nyas.13062 PubMed
[5] N Sivaranjani et al.. J Clin Diagn Res. 2013. Role of reactive oxygen species and antioxidants in atopic dermatitis. doi:10.7860/JCDR/2013/6635.3732 PubMed
[6] Fredric J Pashkow et al.. Am J Cardiol. 2008. Astaxanthin: a novel potential treatment for oxidative stress and inflammation in cardiovascular disease. doi:10.1016/j.amjcard.2008.02.010 PubMed

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Vitamin E لـ Atherosclerosis

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الخلاصة

Key Study Findings

Key Statistics

Referenced Papers

Dosage & Usage

الجرعات الشائعة

الجرعات المدروسة في الأبحاث

Safety & Side Effects

الآثار الجانبية المُبلّغ عنها

التفاعلات المعروفة

Frequently Asked Questions

Related Evidence

مكونات أخرى لـ Atherosclerosis

References