Resveratrol لـ Atherosclerosis
C الأدلة أدلة محدودة من دراسات صغيرة، غير أن ثمة بعض الإشارات الإيجابية.Improves FMD and reduces inflammatory markers. RESVACE trial was negative for cardiac function in heart failure. Bioavailability challenges limit clinical translation.
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C
الخلاصة
Improves FMD and reduces inflammatory markers. RESVACE trial was negative for cardiac function in heart failure. Bioavailability challenges limit clinical translation.
Key Study Findings
Review
Dietary Antioxidants, Polyphenols, and Vascular Health: Insights From Ultrasound Measurement of Carotid Intima-Media Thickness and …
Dose: None
مقابل: None
Outcome: None
التأثير: None
None
المجتمع المدروس: older adults and individuals with neurodegenerative disorders
Review
Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues.
Dose: None
مقابل: None
Outcome: None
التأثير: None
None
المجتمع المدروس: review of age-related cardiac dysfunction and heart failure mechanisms
Review
Navigating the Effects of Anti-Atherosclerotic Supplements and Acknowledging Associated Bleeding Risks.
Dose: None
مقابل: None
Outcome: None
التأثير: None
None
المجتمع المدروس: Review of anti-atherosclerotic supplements and bleeding
Review
Resveratrol inhibiting TGF/ERK signaling pathway can improve atherosclerosis: backgrounds, mechanisms and effects.
Dose: None
مقابل: None
Outcome: TGF/ERK pathway inhibition and AS improvement
التأثير: None
None
المجتمع المدروس: Atherosclerosis populations
In Vitro
Genome-Wide Transcriptional Profiling Reveals PHACTR1 as a Novel Molecular Target of Resveratrol in Endothelial Homeostasis.
Dose: None
مقابل: None
Outcome: None
التأثير: None
None
المجتمع المدروس: None
Other
Supplementation with Resveratrol, Piperine and Alpha-Tocopherol Decreases Chronic Inflammation in a Cluster of Older Adults …
Dose: None
مقابل: Conventional treatment
Outcome: effect of a dietary supplement on chronic inflammation …
التأثير: None
p < 0.05
المجتمع المدروس: None
Key Statistics
5
الدراسات
400
المشاركون
↑
Positive
C
التقييم
Referenced Papers
Phytotherapy research : …
2026
ESC heart failure
2025
58 اقتباسات
International journal of …
2025
1 اقتباسات
Biomedicine & pharmacotherapy …
2022
34 اقتباسات
Nutrients
2022
2 اقتباسات
Nutrients
2020
16 اقتباسات
Pharmacological research
2019
31 اقتباسات
Nutrients
2018
77 اقتباسات
Oxidative medicine and …
2017
87 اقتباسات
Pharmacological research
2017
63 اقتباسات
Inhibition of pattern recognition receptor-mediated inflammation by bioactive phytochemicals.
Review
Nutrition reviews
2011
97 اقتباسات
Journal of cardiovascular …
2009
297 اقتباسات
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
الجرعات الشائعة
- general:
- 150-500 mg/day
- cardiovascularsupport:
- 250-500 mg/day trans-resveratrol
الحد الأعلى: Not formally established; GI discomfort common above 1,000 mg/day
الجرعات المدروسة في الأبحاث
| الجرعة | المدة | التأثير | ن |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Neutral | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
أفضل وقت للتناول: With meals; bioavailability enhanced by piperine co-supplementation
Safety & Side Effects
الآثار الجانبية المُبلّغ عنها
- ⚠ Gastrointestinal discomfort (nausea, diarrhea, cramping) at high doses
- ⚠ Headache
- ⚠ May have estrogenic activity at high doses
التفاعلات المعروفة
- ● Anticoagulants (may inhibit platelet aggregation)
- ● CYP450 substrates (may inhibit CYP1A2, CYP3A4, CYP2D6)
- ● Blood pressure medications (additive hypotensive effect)
- ● Estrogen-sensitive conditions (weak estrogenic activity)
الحد الأقصى المسموح به: Not formally established; GI discomfort common above 1,000 mg/day
استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.
Frequently Asked Questions
Does Resveratrol help with Atherosclerosis?
Based on 5 studies with 400 participants, there is limited but promising evidence that Resveratrol may support Atherosclerosis management. Our evidence grade is C (Some Evidence).
How much Resveratrol should I take for Atherosclerosis?
Studies have used various dosages. A commonly studied range is 150-500 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Resveratrol?
Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea, cramping) at high doses, Headache, May have estrogenic activity at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Resveratrol and Atherosclerosis?
We rate the evidence as Grade C (Some Evidence). This rating is based on 5 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.
Related Evidence
مكونات أخرى لـ Atherosclerosis
Resveratrol لحالات أخرى
References
- [1] Lei Wang et al.. Phytother Res. 2026. Dietary Antioxidants, Polyphenols, and Vascular Health: Insights From Ultrasound Measurement of Carotid Intima-Media Thickness and Their Association With Cognitive Function … doi:10.1002/ptr.70198 PubMed
- [2] Zhuyubing Fang et al.. ESC Heart Fail. 2025. Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues. doi:10.1002/ehf2.14947 PubMed
- [3] Maria-Zinaida Dobre et al.. Int J Mol Sci. 2025. Navigating the Effects of Anti-Atherosclerotic Supplements and Acknowledging Associated Bleeding Risks. doi:10.3390/ijms262010183 PubMed
- [4] Shitian Guo et al.. Biomed Pharmacother. 2022. Resveratrol inhibiting TGF/ERK signaling pathway can improve atherosclerosis: backgrounds, mechanisms and effects. doi:10.1016/j.biopha.2022.113775 PubMed
- [5] Meiming Su et al.. Nutrients. 2022. Genome-Wide Transcriptional Profiling Reveals PHACTR1 as a Novel Molecular Target of Resveratrol in Endothelial Homeostasis. doi:10.3390/nu14214518 PubMed
- [6] Raúl Francisco Pastor et al.. Nutrients. 2020. Supplementation with Resveratrol, Piperine and Alpha-Tocopherol Decreases Chronic Inflammation in a Cluster of Older Adults with Metabolic Syndrome. doi:10.3390/nu12103149 PubMed
- [7] Wang Anlu et al.. Pharmacol Res. 2019. Using herbal medicine to target the "microbiota-metabolism-immunity" axis as possible therapy for cardiovascular disease. doi:10.1016/j.phrs.2019.02.018 PubMed
- [8] Michał Wiciński et al.. Nutrients. 2018. Beneficial Effects of Resveratrol Administration-Focus on Potential Biochemical Mechanisms in Cardiovascular Conditions. doi:10.3390/nu10111813 PubMed
- [9] A Tressera-Rimbau et al.. Oxid Med Cell Longev. 2017. Dietary Polyphenols in the Prevention of Stroke. doi:10.1155/2017/7467962 PubMed
- [10] Enrico Gugliandolo et al.. Pharmacol Res. 2017. Palmitoylethanolamide and Polydatin combination reduces inflammation and oxidative stress in vascular injury. doi:10.1016/j.phrs.2017.06.014 PubMed
- [11] Ling Zhao et al.. Nutr Rev. 2011. Inhibition of pattern recognition receptor-mediated inflammation by bioactive phytochemicals. doi:10.1111/j.1753-4887.2011.00394.x PubMed
- [12] Alberto A A Bertelli et al.. J Cardiovasc Pharmacol. 2009. Grapes, wines, resveratrol, and heart health. doi:10.1097/FJC.0b013e3181bfaff3 PubMed
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