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Resveratrol لـ High Blood Pressure (Hypertension)

B الأدلة تدعم ذلك تجربة عشوائية واحدة على الأقل، مع نتائج متسقة في معظمها.

Meta-analysis: systolic -11.9 mmHg in hypertensives at >=150 mg/day. Improved flow-mediated dilation in multiple RCTs. Bioavailability limitations noted.

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B

الخلاصة

Meta-analysis: systolic -11.9 mmHg in hypertensives at >=150 mg/day. Improved flow-mediated dilation in multiple RCTs. Bioavailability limitations noted.

Key Study Findings

Review
Nutrition and Lifestyle Interventions in Managing Dyslipidemia and Cardiometabolic Risk.
Dose: None مقابل: None Outcome: None التأثير: None None

المجتمع المدروس: review of nutrition and lifestyle interventions for dyslipidemia and cardiometabolic risk

Review
Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues.
Dose: None مقابل: None Outcome: None التأثير: None None

المجتمع المدروس: review of age-related cardiac dysfunction and heart failure mechanisms

Review
Dietary supplements and prevention of preeclampsia.
Dose: 500 mg daily مقابل: Placebo Outcome: Preeclampsia risk reduction التأثير: ~50% risk reduction None

المجتمع المدروس: Pregnant women with low calcium intake

Systematic Review
The Effects of Resveratrol on Menopausal Cardio-metabolic Changes: A Systematic Review.
Dose: None مقابل: Placebo or no treatment Outcome: Cardiometabolic changes in menopausal women التأثير: None None

المجتمع المدروس: Menopausal women

Controlled Clinical Trial
Resveratrol inhibits cerebral aneurysms in mice via downregulating the NF-κB pathway.
Dose: None مقابل: Model group (no RES) and sham control Outcome: Cerebral aneurysm formation التأثير: None P<0.05

المجتمع المدروس: Mice with induced hypertension CA model

Review
The Role of Resveratrol Administration in Human Obesity.
Dose: None مقابل: None Outcome: None التأثير: None None

المجتمع المدروس: Obese adults

Key Statistics

10

الدراسات

600

المشاركون

Positive

B

التقييم

Referenced Papers

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

الجرعات الشائعة

general:
150-500 mg/day
cardiovascularsupport:
250-500 mg/day trans-resveratrol

الحد الأعلى: Not formally established; GI discomfort common above 1,000 mg/day

الجرعات المدروسة في الأبحاث

الجرعة المدة التأثير ن
None -- Positive --
None -- Neutral --
500 mg daily -- Positive --
None -- Positive --
None -- Positive --
None -- Mixed --
75 mg 14 weeks Positive 129
None -- Mixed --

أفضل وقت للتناول: With meals; bioavailability enhanced by piperine co-supplementation

Safety & Side Effects

الآثار الجانبية المُبلّغ عنها

  • Gastrointestinal discomfort (nausea, diarrhea, cramping) at high doses
  • Headache
  • May have estrogenic activity at high doses

التفاعلات المعروفة

  • Anticoagulants (may inhibit platelet aggregation)
  • CYP450 substrates (may inhibit CYP1A2, CYP3A4, CYP2D6)
  • Blood pressure medications (additive hypotensive effect)
  • Estrogen-sensitive conditions (weak estrogenic activity)

الحد الأقصى المسموح به: Not formally established; GI discomfort common above 1,000 mg/day

استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.

Frequently Asked Questions

Does Resveratrol help with High Blood Pressure (Hypertension)?
Based on 10 studies with 600 participants, there is moderate evidence from clinical studies that Resveratrol may support High Blood Pressure (Hypertension) management. Our evidence grade is B (Good Evidence).
How much Resveratrol should I take for High Blood Pressure (Hypertension)?
Studies have used various dosages. A commonly studied range is 150-500 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Resveratrol?
Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea, cramping) at high doses, Headache, May have estrogenic activity at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Resveratrol and High Blood Pressure (Hypertension)?
We rate the evidence as Grade B (Good Evidence). This rating is based on 10 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.

Resveratrol لحالات أخرى

References

  1. [1] Zhuyubing Fang et al.. ESC Heart Fail. 2025. Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues. doi:10.1002/ehf2.14947 PubMed
  2. [2] Hygerta Berisha et al.. Nutrients. 2025. Nutrition and Lifestyle Interventions in Managing Dyslipidemia and Cardiometabolic Risk. doi:10.3390/nu17050776 PubMed
  3. [3] Takafumi Ushida et al.. Hypertens Res. 2025. Dietary supplements and prevention of preeclampsia. doi:10.1038/s41440-025-02144-9 PubMed
  4. [4] Ali Amini et al.. Cardiovasc Hematol Disord Drug Targets. 2025. The Effects of Resveratrol on Menopausal Cardio-metabolic Changes: A Systematic Review. doi:10.2174/011871529X398468250910225946 PubMed
  5. [5] Tao Jin et al.. Acta Biochim Pol. 2022. Resveratrol inhibits cerebral aneurysms in mice via downregulating the NF-κB pathway. doi:10.18388/abp.2020_5982 PubMed
  6. [6] Laura M Mongioì et al.. Int J Mol Sci. 2021. The Role of Resveratrol Administration in Human Obesity. doi:10.3390/ijms22094362 PubMed
  7. [7] Jay Jay Thaung Zaw et al.. Nutrients. 2020. Sustained Cerebrovascular and Cognitive Benefits of Resveratrol in Postmenopausal Women. doi:10.3390/nu12030828 PubMed
  8. [8] Raúl Francisco Pastor et al.. Nutrients. 2020. Supplementation with Resveratrol, Piperine and Alpha-Tocopherol Decreases Chronic Inflammation in a Cluster of Older Adults with Metabolic Syndrome. doi:10.3390/nu12103149 PubMed
  9. [9] Ligia J Dominguez et al.. Acta Biomed. 2018. Nutritional prevention of cognitive decline and dementia. doi:10.23750/abm.v89i2.7401 PubMed

إخلاء مسؤولية FDA: لم تُقيَّم هذه البيانات من قبل إدارة الغذاء والدواء (FDA). لا تهدف المنتجات والمعلومات الواردة في هذا الموقع إلى تشخيص أو علاج أو شفاء أو الوقاية من أي مرض. تستند تقييمات الأدلة المعروضة إلى تحليلنا للأبحاث المحكّمة المنشورة ولا تُشكّل نصيحة طبية. استشر مقدم الرعاية الصحية دائماً قبل البدء بأي نظام مكملات.