Resveratrol ： High Blood Pressure (Hypertension)

Q: Does Resveratrol help with High Blood Pressure (Hypertension)?

Based on 10 studies with 600 participants, there is moderate evidence from clinical studies that Resveratrol may support High Blood Pressure (Hypertension) management. Our evidence grade is B (Good Evidence).

Q: How much Resveratrol should I take for High Blood Pressure (Hypertension)?

Studies have used various dosages. A commonly studied range is 150-500 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Resveratrol?

Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea, cramping) at high doses, Headache, May have estrogenic activity at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Resveratrol and High Blood Pressure (Hypertension)?

We rate the evidence as Grade B (Good Evidence). This rating is based on 10 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.

B エビデンス少なくとも1件のランダム化試験がこれを支持しており、おおむね一貫した結果が得られています。

Meta-analysis: systolic -11.9 mmHg in hypertensives at >=150 mg/day. Improved flow-mediated dilation in multiple RCTs. Bioavailability limitations noted.

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結論

Meta-analysis: systolic -11.9 mmHg in hypertensives at >=150 mg/day. Improved flow-mediated dilation in multiple RCTs. Bioavailability limitations noted.

Key Study Findings

Review

Nutrition and Lifestyle Interventions in Managing Dyslipidemia and Cardiometabolic Risk.

Dose: None vs: None Outcome: None 効果: None None

対象集団: review of nutrition and lifestyle interventions for dyslipidemia and cardiometabolic risk

Review

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues.

Dose: None vs: None Outcome: None 効果: None None

対象集団: review of age-related cardiac dysfunction and heart failure mechanisms

Review

Dietary supplements and prevention of preeclampsia.

Dose: 500 mg daily vs: Placebo Outcome: Preeclampsia risk reduction 効果: ~50% risk reduction None

対象集団: Pregnant women with low calcium intake

Systematic Review

The Effects of Resveratrol on Menopausal Cardio-metabolic Changes: A Systematic Review.

Dose: None vs: Placebo or no treatment Outcome: Cardiometabolic changes in menopausal women 効果: None None

対象集団: Menopausal women

Controlled Clinical Trial

Resveratrol inhibits cerebral aneurysms in mice via downregulating the NF-κB pathway.

Dose: None vs: Model group (no RES) and sham control Outcome: Cerebral aneurysm formation 効果: None P<0.05

対象集団: Mice with induced hypertension CA model

Review

The Role of Resveratrol Administration in Human Obesity.

Dose: None vs: None Outcome: None 効果: None None

対象集団: Obese adults

Key Statistics

研究数

600

参加者数

↑

Positive

グレード

Referenced Papers

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues. Review

ESC heart failure 2025 58 件の引用

Nutrition and Lifestyle Interventions in Managing Dyslipidemia and Cardiometabolic Risk. Review

Nutrients 2025 32 件の引用

Dietary supplements and prevention of preeclampsia. Review

Hypertension research : … 2025 10 件の引用

The Effects of Resveratrol on Menopausal Cardio-metabolic Changes: A Systematic Review. Other

Cardiovascular & hematological … 2025

Resveratrol inhibits cerebral aneurysms in mice via downregulating the NF-κB pathway. Other

Acta biochimica Polonica 2022 10 件の引用

The Role of Resveratrol Administration in Human Obesity. Review

International journal of … 2021 50 件の引用

Sustained Cerebrovascular and Cognitive Benefits of Resveratrol in Postmenopausal Women. Other

Nutrients 2020 49 件の引用

Supplementation with Resveratrol, Piperine and Alpha-Tocopherol Decreases Chronic Inflammation in a Cluster of Older Adults with Metabolic Syndrome. Other

Nutrients 2020 16 件の引用

Nutritional prevention of cognitive decline and dementia. Review

Acta bio-medica : … 2018 103 件の引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

general:: 150-500 mg/day
cardiovascularsupport:: 250-500 mg/day trans-resveratrol

上限量： Not formally established; GI discomfort common above 1,000 mg/day

研究で検討された用量

用量	期間	効果	N
None	--	Positive	--
None	--	Neutral	--
500 mg daily	--	Positive	--
None	--	Positive	--
None	--	Positive	--
None	--	Mixed	--
75 mg	14 weeks	Positive	129
None	--	Mixed	--

推奨摂取タイミング： With meals; bioavailability enhanced by piperine co-supplementation

Safety & Side Effects

報告されている副作用

⚠ Gastrointestinal discomfort (nausea, diarrhea, cramping) at high doses
⚠ Headache
⚠ May have estrogenic activity at high doses

既知の相互作用

● Anticoagulants (may inhibit platelet aggregation)
● CYP450 substrates (may inhibit CYP1A2, CYP3A4, CYP2D6)
● Blood pressure medications (additive hypotensive effect)
● Estrogen-sensitive conditions (weak estrogenic activity)

耐容上限摂取量： Not formally established; GI discomfort common above 1,000 mg/day

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does Resveratrol help with High Blood Pressure (Hypertension)?

Based on 10 studies with 600 participants, there is moderate evidence from clinical studies that Resveratrol may support High Blood Pressure (Hypertension) management. Our evidence grade is B (Good Evidence).

How much Resveratrol should I take for High Blood Pressure (Hypertension)?

Studies have used various dosages. A commonly studied range is 150-500 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Resveratrol?

Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea, cramping) at high doses, Headache, May have estrogenic activity at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Resveratrol and High Blood Pressure (Hypertension)?

We rate the evidence as Grade B (Good Evidence). This rating is based on 10 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.

に関する他の成分： High Blood Pressure (Hypertension)

Beetroot Extract A Garlic A Magnesium B Potassium B Quercetin B Grape Seed Extract B

Resveratrol 他の症状・状態について

Atherosclerosis C

総合評価

Meta-analysis: systolic -11.9 mmHg in hypertensives at >=150 mg/day. Improved flow-mediated dilation in multiple RCTs. Bioavailability limitations noted.

Evidence Strength72%

High confidence

研究の内訳

RCT (0)Meta (0)Other (10)

代替成分との比較

この症状に対する他の成分との比較をご覧ください。

に関するすべての成分を見る： High Blood Pressure (Hypertension)

詳しく見る

References

[1] Zhuyubing Fang et al.. ESC Heart Fail. 2025. Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues. doi:10.1002/ehf2.14947 PubMed
[2] Hygerta Berisha et al.. Nutrients. 2025. Nutrition and Lifestyle Interventions in Managing Dyslipidemia and Cardiometabolic Risk. doi:10.3390/nu17050776 PubMed
[3] Takafumi Ushida et al.. Hypertens Res. 2025. Dietary supplements and prevention of preeclampsia. doi:10.1038/s41440-025-02144-9 PubMed
[4] Ali Amini et al.. Cardiovasc Hematol Disord Drug Targets. 2025. The Effects of Resveratrol on Menopausal Cardio-metabolic Changes: A Systematic Review. doi:10.2174/011871529X398468250910225946 PubMed
[5] Tao Jin et al.. Acta Biochim Pol. 2022. Resveratrol inhibits cerebral aneurysms in mice via downregulating the NF-κB pathway. doi:10.18388/abp.2020_5982 PubMed
[6] Laura M Mongioì et al.. Int J Mol Sci. 2021. The Role of Resveratrol Administration in Human Obesity. doi:10.3390/ijms22094362 PubMed
[7] Jay Jay Thaung Zaw et al.. Nutrients. 2020. Sustained Cerebrovascular and Cognitive Benefits of Resveratrol in Postmenopausal Women. doi:10.3390/nu12030828 PubMed
[8] Raúl Francisco Pastor et al.. Nutrients. 2020. Supplementation with Resveratrol, Piperine and Alpha-Tocopherol Decreases Chronic Inflammation in a Cluster of Older Adults with Metabolic Syndrome. doi:10.3390/nu12103149 PubMed
[9] Ligia J Dominguez et al.. Acta Biomed. 2018. Nutritional prevention of cognitive decline and dementia. doi:10.23750/abm.v89i2.7401 PubMed

FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Resveratrol ： High Blood Pressure (Hypertension)

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結論

Key Study Findings

Key Statistics

Referenced Papers

Dosage & Usage

一般的な使用量

研究で検討された用量

Safety & Side Effects

報告されている副作用

既知の相互作用

Frequently Asked Questions

Related Evidence

に関する他の成分： High Blood Pressure (Hypertension)

Resveratrol 他の症状・状態について

References