Garlic : High Blood Pressure (Hypertension)
A エビデンス 複数の大規模臨床試験が一貫して有意な効果を示しています。Meta-analysis of 12 RCTs: systolic -8.3 mmHg, diastolic -5.5 mmHg in hypertensives. Effect may be comparable to first-line antihypertensives. AGE at Heart trial showed 80% reduction in coronary calcium progression.
結論
Meta-analysis of 12 RCTs: systolic -8.3 mmHg, diastolic -5.5 mmHg in hypertensives. Effect may be comparable to first-line antihypertensives. AGE at Heart trial showed 80% reduction in coronary calcium progression.
Key Study Findings
対象集団: Older adults at risk of cognitive decline
対象集団: Women using herbal remedies
対象集団: Women
対象集団: hypertensive patients
Key Statistics
12
研究数
550
参加者数
Positive
グレード
Referenced Papers
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- freshgarlic:
- 2-5g/day (1-2 cloves)
- agedgarlicextract:
- 600-1,200 mg/day
- allicinstandardized:
- 300-600 mg/day (5-12 mg allicin)
上限量: Not formally established; GI discomfort and body odor limit high doses
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Mixed | -- |
| Various herbs (black cohosh, chasteberry, dong quai, etc.) | -- | Mixed | -- |
| Various herbs used by women | -- | Mixed | -- |
| None | -- | Mixed | -- |
推奨摂取タイミング: With meals to reduce GI side effects; enteric-coated tablets for allicin delivery
Safety & Side Effects
報告されている副作用
- ⚠ Body odor and bad breath (less with AGE)
- ⚠ Gastrointestinal discomfort (heartburn, nausea, gas)
- ⚠ Increased bleeding risk
- ⚠ Allergic reactions (rare)
既知の相互作用
- ● Anticoagulants (increased bleeding risk — discontinue 7 days before surgery)
- ● Antiplatelet drugs (additive antiplatelet effect)
- ● HIV protease inhibitors (saquinavir — reduced levels)
- ● CYP3A4 substrates (may alter metabolism)
- ● Blood pressure medications (additive hypotensive effect)
耐容上限摂取量: Not formally established; GI discomfort and body odor limit high doses
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Garlic help with High Blood Pressure (Hypertension)?
How much Garlic should I take for High Blood Pressure (Hypertension)?
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Related Evidence
に関する他の成分: High Blood Pressure (Hypertension)
References
- [1] Ligia J Dominguez et al.. Acta Biomed. 2018. Nutritional prevention of cognitive decline and dementia. doi:10.23750/abm.v89i2.7401 PubMed
- [2] Bonnie J Tesch. Am J Obstet Gynecol. 2003. Herbs commonly used by women: an evidence-based review. doi:10.1067/mob.2003.402 PubMed
- [3] Bonnie J Tesch. Dis Mon. 2002. Herbs commonly used by women: an evidence-based review. PubMed
- [4] T B Klepser et al.. Am J Health Syst Pharm. 1999. Unsafe and potentially safe herbal therapies. doi:10.1093/ajhp/56.2.125 PubMed
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