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L-Citrulline ： High Blood Pressure (Hypertension)

C エビデンス 小規模研究からのエビデンスは限られていますが、いくつかの肯定的なシグナルがあります。

Systolic -4.1 mmHg in meta-analysis. May have superior pharmacokinetics vs. arginine for sustained nitric oxide production. Growing evidence base but still smaller than other BP-lowering supplements.

C

結論

Systolic -4.1 mmHg in meta-analysis. May have superior pharmacokinetics vs. arginine for sustained nitric oxide production. Growing evidence base but still smaller than other BP-lowering supplements.

Key Statistics

7

研究数

400

参加者数

↑

Positive

C

グレード

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

lcitrulline:
3,000-6,000 mg/day
citrullinemalate:
6,000-8,000 mg/day
bloodpressuresupport:
3,000 mg/day

上限量： Not formally established; well-tolerated up to 15,000 mg/day in clinical trials

推奨摂取タイミング： On empty stomach; divide doses for sustained arginine elevation

Safety & Side Effects

報告されている副作用

  • ⚠ Generally well-tolerated
  • ⚠ Mild gastrointestinal discomfort at high doses
  • ⚠ Heartburn (rare)

既知の相互作用

  • ● Antihypertensives (additive blood pressure lowering)
  • ● PDE5 inhibitors (excessive vasodilation risk)
  • ● Nitrates (excessive vasodilation risk)

耐容上限摂取量： Not formally established; well-tolerated up to 15,000 mg/day in clinical trials

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does L-Citrulline help with High Blood Pressure (Hypertension)?
Based on 7 studies with 400 participants, there is limited but promising evidence that L-Citrulline may support High Blood Pressure (Hypertension) management. Our evidence grade is C (Some Evidence).
How much L-Citrulline should I take for High Blood Pressure (Hypertension)?
Studies have used various dosages. A commonly studied range is 3,000-6,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of L-Citrulline?
Reported side effects may include Generally well-tolerated, Mild gastrointestinal discomfort at high doses, Heartburn (rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for L-Citrulline and High Blood Pressure (Hypertension)?
We rate the evidence as Grade C (Some Evidence). This rating is based on 7 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.

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        FDAに関する免責事項:
        これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。