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Quercetin لـ High Blood Pressure (Hypertension)

B الأدلة تدعم ذلك تجربة عشوائية واحدة على الأقل، مع نتائج متسقة في معظمها.

Meta-analysis of 17 RCTs: systolic -3.09 mmHg at >=500 mg/day. More effective in >=8-week studies and hypertensive subjects. Phytosome form preferred for bioavailability.

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B

الخلاصة

Meta-analysis of 17 RCTs: systolic -3.09 mmHg at >=500 mg/day. More effective in >=8-week studies and hypertensive subjects. Phytosome form preferred for bioavailability.

Key Study Findings

In Vitro
Kyoh® Rocket Leaf Extract Regulates Proliferation and VEGF and FGF7 Expression in Human Dermal Follicle …
Dose: None مقابل: Untreated dermal follicle papilla cells Outcome: VEGF and FGF7 gene expression التأثير: VEGF +267.3%, FGF7 +244.3% at 24h None

المجتمع المدروس: Human dermal follicle papilla cells (in vitro)

Review
Quercetin and Its Lecithin-Based Formulation: Potential Applications for Allergic Diseases Based on a Narrative Review.
Dose: None مقابل: None Outcome: None التأثير: None None

المجتمع المدروس: None

Review
Effects of plant-derived dietary antioxidants on Alzheimer's disease: Focus on ferroptosis.
Dose: None مقابل: None Outcome: Cognitive decline via ferroptosis regulation in AD التأثير: None None

المجتمع المدروس: AD patients and healthy elderly

Review
Anti-Inflammatory Actions of Plant-Derived Compounds and Prevention of Chronic Diseases: From Molecular Mechanisms to Applications.
Dose: None مقابل: None Outcome: None التأثير: None None

المجتمع المدروس: review of plant-derived anti-inflammatory compounds for chronic disease prevention

Other
Exploration of Potential Targets and Molecular Mechanisms of the Yiqi Jianpi Tongqiao Formula in Treating …
Dose: None مقابل: Allergic rhinitis mouse model vs control Outcome: Rhinitis symptoms and serum inflammatory indicators التأثير: None None

المجتمع المدروس: Allergic rhinitis mouse model

Review
The Roles of Flavonoids and Other Plant-Based Phenolics in Mitigating Diabetes-Induced Macrovascular Complications.
Dose: None مقابل: None Outcome: None التأثير: None None

المجتمع المدروس: Review of flavonoids/phenolics in diabetic macrovascular

Key Statistics

17

الدراسات

900

المشاركون

Positive

B

التقييم

Referenced Papers

Indian journal of … 2024 2 اقتباسات
Voprosy pitaniia 2023 19 اقتباسات
International journal of … 2022 23 اقتباسات
Medicines (Basel, Switzerland) 2021 16 اقتباسات
Biomedicine & pharmacotherapy … 2020 427 اقتباسات
Oxidative medicine and … 2017 87 اقتباسات
International journal of … 2006 92 اقتباسات
Current drug targets 2006 92 اقتباسات
Alternative medicine review … 2000

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

الجرعات الشائعة

general:
500-1,000 mg/day
bloodpressuresupport:
500-730 mg/day

الحد الأعلى: Not formally established; up to 1,000 mg/day used in clinical trials

الجرعات المدروسة في الأبحاث

الجرعة المدة التأثير ن
None -- Positive --
None -- Mixed --
None -- Positive --
None -- Positive --
None -- Positive --
None -- Mixed --
None -- Positive --
None -- Positive --

أفضل وقت للتناول: With meals; vitamin C co-supplementation may enhance bioavailability

Safety & Side Effects

الآثار الجانبية المُبلّغ عنها

  • Generally well-tolerated
  • Headache (rare)
  • Mild gastrointestinal discomfort
  • Tingling in extremities (rare, high doses)

التفاعلات المعروفة

  • Antibiotics (quinolones — may reduce efficacy)
  • Cyclosporine (may increase blood levels)
  • Anticoagulants (may have mild antiplatelet effect)
  • Blood pressure medications (additive effect)

الحد الأقصى المسموح به: Not formally established; up to 1,000 mg/day used in clinical trials

استشر مقدم الرعاية الصحية دائماً قبل البدء بأي مكمل غذائي.

Frequently Asked Questions

Does Quercetin help with High Blood Pressure (Hypertension)?
Based on 17 studies with 900 participants, there is moderate evidence from clinical studies that Quercetin may support High Blood Pressure (Hypertension) management. Our evidence grade is B (Good Evidence).
How much Quercetin should I take for High Blood Pressure (Hypertension)?
Studies have used various dosages. A commonly studied range is 500-1,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Quercetin?
Reported side effects may include Generally well-tolerated, Headache (rare), Mild gastrointestinal discomfort, Tingling in extremities (rare, high doses). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Quercetin and High Blood Pressure (Hypertension)?
We rate the evidence as Grade B (Good Evidence). This rating is based on 17 peer-reviewed studies with 900 total participants. The overall direction of effect is positive.

Quercetin لحالات أخرى

References

  1. [1] Kazuhiko Nakadate et al.. Int J Mol Sci. 2025. Anti-Inflammatory Actions of Plant-Derived Compounds and Prevention of Chronic Diseases: From Molecular Mechanisms to Applications. doi:10.3390/ijms26115206 PubMed
  2. [2] Monika Martiniakova et al.. Nutrients. 2025. Protective Role of Dietary Polyphenols in the Management and Treatment of Type 2 Diabetes Mellitus. doi:10.3390/nu17020275 PubMed
  3. [3] Matteo Naso et al.. Nutrients. 2025. Quercetin and Its Lecithin-Based Formulation: Potential Applications for Allergic Diseases Based on a Narrative Review. doi:10.3390/nu17091476 PubMed
  4. [4] Xing-Yuan Li et al.. J Ethnopharmacol. 2025. Inhibition of mitochondrial oxidative stress and apoptosis in the protection of Ginkgo biloba extract 50 against cognitive impairment. doi:10.1016/j.jep.2025.120059 PubMed
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  7. [7] Feng Gu et al.. Asia Pac J Clin Nutr. 2025. Effects of plant-derived dietary antioxidants on Alzheimer's disease: Focus on ferroptosis. doi:10.6133/apjcn.202512_34(6).0007 PubMed
  8. [8] Aminu Mohammed et al.. Phytother Res. 2025. The Roles of Flavonoids and Other Plant-Based Phenolics in Mitigating Diabetes-Induced Macrovascular Complications. doi:10.1002/ptr.70070 PubMed
  9. [9] Adal Mena-García et al.. Molecules. 2025. Kyoh® Rocket Leaf Extract Regulates Proliferation and VEGF and FGF7 Expression in Human Dermal Follicle Papilla Cells. doi:10.3390/molecules30071489 PubMed
  10. [10] Masoumeh Shamsi et al.. Iran J Pharm Res. 2024. Dual Modulation of Canonical and Non-canonical TGF-β/ROS/Erk1/2 Pathways: Synergistic Activation of Nrf-2 and Antioxidant Enzymes (SOD1, GPx, HO-1) by Quercetin … doi:10.5812/ijpr-151428 PubMed
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  13. [13] Sina Kaag et al.. Cells. 2023. Effects of Dietary Components on Mast Cells: Possible Use as Nutraceuticals for Allergies? doi:10.3390/cells12222602 PubMed
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  18. [18] Takayuki Okumo et al.. Medicines (Basel). 2021. Inhibition of Angiogenic Factor Productions by Quercetin In Vitro and In Vivo. doi:10.3390/medicines8050022 PubMed
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