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Vitamin E 관련 Atherosclerosis

C

Strong mechanistic rationale (LDL oxidation inhibition) but large RCTs (HOPE, GISSI-Prevenzione) show no benefit. Meta-analysis suggests potential harm at >=400 IU/day. AHA does not recommend supplementation.

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            C

        

        

            
결론

            
            
Strong mechanistic rationale (LDL oxidation inhibition) but large RCTs (HOPE, GISSI-Prevenzione) show no benefit. Meta-analysis suggests potential harm at >=400 IU/day. AHA does not recommend supplementation.

            
            
        

    











    
    

        
        

            

  
Key Statistics





            


    

        
15

        
연구

    

    

        
50000

        
참여자

    

    

        
            
            ↔
            
        
        
Mixed

    

    

        C

        
등급

    




        


        
        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
일반적으로 사용되는 용량

                

                    
                    

                        
note:

                        
High-dose supplementation no longer recommended based on clinical trial evidence

                    

                    
                    

                        
general:

                        
15 mg/day (22.4 IU)

                    

                    
                

                
                

                    상한량: 1,000 mg/day (1,500 IU natural, 1,100 IU synthetic)
                

                
            

            

            

            
            

                권장 복용 시간: With meals containing fat
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
보고된 부작용

                    
    
                        
                        
  • 
                            ⚠
                            Increased bleeding risk at high doses
                        
    • 
                        
                        
  • 
                            ⚠
                            Possible increased all-cause mortality at >=400 IU/day
                        
    • 
                        
                        
  • 
                            ⚠
                            Increased heart failure hospitalization risk (HOPE/HOPE-TOO)
                        
    • 
                        
                        
  • 
                            ⚠
                            Nausea, diarrhea, fatigue at high doses
                        
    • 
                        
                    

                

                

                
                

                    
알려진 상호작용

                    
    
                        
                        
  • 
                            ●
                            Anticoagulants (increased bleeding risk)
                        
    • 
                        
                        
  • 
                            ●
                            Statins and niacin (may blunt HDL-raising effect)
                        
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  • 
                            ●
                            Chemotherapy and radiation (theoretical interference with oxidative mechanisms)
                        
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  • 
                            ●
                            Vitamin K (may antagonize at high doses)
                        
    • 
                        
                    

                

                

                
                

                    

                        일일 최대 섭취 허용량: 1,000 mg/day (1,500 IU natural, 1,100 IU synthetic)
                    

                

                
            

            

                건강기능식품을 복용하기 전에 반드시 의료 전문가와 상담하십시오.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Vitamin E help with Atherosclerosis?
            
        
        

            Based on 15 studies with 50,000 participants, there is limited but promising evidence that Vitamin E may support Atherosclerosis management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much Vitamin E should I take for Atherosclerosis?
            
        
        

            Studies have used various dosages. A commonly studied range is High-dose supplementation no longer recommended based on clinical trial evidence. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Vitamin E?
            
        
        

            Reported side effects may include Increased bleeding risk at high doses, Possible increased all-cause mortality at >=400 IU/day, Increased heart failure hospitalization risk (HOPE/HOPE-TOO), Nausea, diarrhea, fatigue at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Vitamin E and Atherosclerosis?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 15 peer-reviewed studies with 50,000 total participants. The overall direction of effect is mixed.
        

    

    




        

        

        
        
        

            

  
Related Evidence





            

                
                
                

                
            

        

        

    


    
    












    

        FDA 면책 조항:
        이 내용은 미국 식품의약국(FDA)의 평가를 받지 않았습니다. 이 웹사이트의 제품 및 정보는 질병의 진단, 치료, 완치 또는 예방을 목적으로 하지 않습니다. 제시된 근거 등급은 발표된 동료 심사 연구에 대한 우리의 분석에 기반하며, 의학적 조언을 구성하지 않습니다. 건강기능식품 복용을 시작하기 전에 반드시 의료 전문가와 상담하십시오.