Vitamin E для Atherosclerosis

C Доказательства Доказательства ограничены небольшими исследованиями, однако имеются некоторые положительные сигналы.

Strong mechanistic rationale (LDL oxidation inhibition) but large RCTs (HOPE, GISSI-Prevenzione) show no benefit. Meta-analysis suggests potential harm at >=400 IU/day. AHA does not recommend supplementation.

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Итог

Key Study Findings

Review

Navigating the Effects of Anti-Atherosclerotic Supplements and Acknowledging Associated Bleeding Risks.

Dose: None или: None Outcome: None Эффект: None None

Популяция: Review of anti-atherosclerotic supplements and bleeding

Other

Extensive Bioactivity of Astaxanthin from Haematococcus pluvialis in Human.

Dose: None или: None Outcome: None Эффект: None None

Популяция: None

Other

Supplementation with Resveratrol, Piperine and Alpha-Tocopherol Decreases Chronic Inflammation in a Cluster of Older Adults …

Dose: None или: Conventional treatment Outcome: effect of a dietary supplement on chronic inflammation … Эффект: None p < 0.05

Популяция: None

Review

Nutrient intake, nutritional status, and cognitive function with aging.

Dose: None или: None Outcome: None Эффект: None None

Популяция: Aging adults (nutrition and cognition)

Review

Role of reactive oxygen species and antioxidants in atopic dermatitis.

Dose: None или: None Outcome: Role of oxidative stress in atopic dermatitis Эффект: None None

Популяция: Patients with atopic dermatitis

Review

Astaxanthin: a novel potential treatment for oxidative stress and inflammation in cardiovascular disease.

Dose: None или: None Outcome: Astaxanthin: a novel potential treatment for oxidative stress … Эффект: None None

Популяция: None

Key Statistics

Исследования

50000

Участники

↔

Mixed

Оценка

Referenced Papers

Navigating the Effects of Anti-Atherosclerotic Supplements and Acknowledging Associated Bleeding Risks. Review

International journal of … 2025 1 цитирований

Extensive Bioactivity of Astaxanthin from Haematococcus pluvialis in Human. Other

Advances in experimental … 2021 13 цитирований

Supplementation with Resveratrol, Piperine and Alpha-Tocopherol Decreases Chronic Inflammation in a Cluster of Older Adults with Metabolic Syndrome. Other

Nutrients 2020 16 цитирований

Nutrient intake, nutritional status, and cognitive function with aging. Review

Annals of the … 2016 89 цитирований

Role of reactive oxygen species and antioxidants in atopic dermatitis. Other

Journal of clinical … 2013 178 цитирований

Astaxanthin: a novel potential treatment for oxidative stress and inflammation in cardiovascular disease. Review

The American journal … 2008 441 цитирований

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Часто используемые дозировки

note:: High-dose supplementation no longer recommended based on clinical trial evidence
general:: 15 mg/day (22.4 IU)

Верхний предел: 1,000 mg/day (1,500 IU natural, 1,100 IU synthetic)

Дозировки, изученные в исследованиях

Дозировка	Длительность	Эффект	N
None	--	Mixed	--
None	--	Positive	--
None	--	Mixed	--
None	--	Mixed	--
None	--	Positive	--
None	--	Positive	--

Лучшее время приёма: With meals containing fat

Safety & Side Effects

Зарегистрированные побочные эффекты

⚠ Increased bleeding risk at high doses
⚠ Possible increased all-cause mortality at >=400 IU/day
⚠ Increased heart failure hospitalization risk (HOPE/HOPE-TOO)
⚠ Nausea, diarrhea, fatigue at high doses

Известные взаимодействия

● Anticoagulants (increased bleeding risk)
● Statins and niacin (may blunt HDL-raising effect)
● Chemotherapy and radiation (theoretical interference with oxidative mechanisms)
● Vitamin K (may antagonize at high doses)

Допустимый верхний уровень потребления: 1,000 mg/day (1,500 IU natural, 1,100 IU synthetic)

Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.

Frequently Asked Questions

Does Vitamin E help with Atherosclerosis?

Based on 15 studies with 50,000 participants, there is limited but promising evidence that Vitamin E may support Atherosclerosis management. Our evidence grade is C (Some Evidence).

How much Vitamin E should I take for Atherosclerosis?

Studies have used various dosages. A commonly studied range is High-dose supplementation no longer recommended based on clinical trial evidence. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Vitamin E?

Reported side effects may include Increased bleeding risk at high doses, Possible increased all-cause mortality at >=400 IU/day, Increased heart failure hospitalization risk (HOPE/HOPE-TOO), Nausea, diarrhea, fatigue at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Vitamin E and Atherosclerosis?

We rate the evidence as Grade C (Some Evidence). This rating is based on 15 peer-reviewed studies with 50,000 total participants. The overall direction of effect is mixed.

Другие ингредиенты для Atherosclerosis

Nattokinase B Resveratrol C Lycopene D Quercetin D Flaxseed Oil D Olive Leaf Extract D

Краткий вывод

Evidence Strength52%

Moderate confidence

Разбор исследований

RCT (0)Meta (0)Other (15)

Сравнить альтернативы

Узнайте, как другие ингредиенты сравниваются при данном состоянии.

Посмотреть все ингредиенты для Atherosclerosis

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References

[1] Maria-Zinaida Dobre et al.. Int J Mol Sci. 2025. Navigating the Effects of Anti-Atherosclerotic Supplements and Acknowledging Associated Bleeding Risks. doi:10.3390/ijms262010183 PubMed
[2] Eiji Yamashita. Adv Exp Med Biol. 2021. Extensive Bioactivity of Astaxanthin from Haematococcus pluvialis in Human. doi:10.1007/978-981-15-7360-6_23 PubMed
[3] Raúl Francisco Pastor et al.. Nutrients. 2020. Supplementation with Resveratrol, Piperine and Alpha-Tocopherol Decreases Chronic Inflammation in a Cluster of Older Adults with Metabolic Syndrome. doi:10.3390/nu12103149 PubMed
[4] Katherine L Tucker. Ann N Y Acad Sci. 2016. Nutrient intake, nutritional status, and cognitive function with aging. doi:10.1111/nyas.13062 PubMed
[5] N Sivaranjani et al.. J Clin Diagn Res. 2013. Role of reactive oxygen species and antioxidants in atopic dermatitis. doi:10.7860/JCDR/2013/6635.3732 PubMed
[6] Fredric J Pashkow et al.. Am J Cardiol. 2008. Astaxanthin: a novel potential treatment for oxidative stress and inflammation in cardiovascular disease. doi:10.1016/j.amjcard.2008.02.010 PubMed

Отказ от ответственности FDA: Данные утверждения не были оценены Управлением по санитарному надзору за качеством пищевых продуктов и медикаментов (FDA). Продукты и информация на этом сайте не предназначены для диагностики, лечения, излечения или профилактики каких-либо заболеваний. Представленные оценки доказательности основаны на нашем анализе опубликованных рецензируемых исследований и не являются медицинской консультацией. Всегда консультируйтесь с лечащим врачом перед началом приёма любых добавок.

Vitamin E для Atherosclerosis

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Итог

Key Study Findings

Key Statistics

Referenced Papers

Dosage & Usage

Часто используемые дозировки

Дозировки, изученные в исследованиях

Safety & Side Effects

Зарегистрированные побочные эффекты

Известные взаимодействия

Frequently Asked Questions

Related Evidence

Другие ингредиенты для Atherosclerosis

References