Vitamin E para Atherosclerosis

C Evidencia Evidencia limitada de estudios pequeños, pero existen algunas señales positivas.

Strong mechanistic rationale (LDL oxidation inhibition) but large RCTs (HOPE, GISSI-Prevenzione) show no benefit. Meta-analysis suggests potential harm at >=400 IU/day. AHA does not recommend supplementation.

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Conclusión

Key Study Findings

Review

Navigating the Effects of Anti-Atherosclerotic Supplements and Acknowledging Associated Bleeding Risks.

Dose: None vs: None Outcome: None Efecto: None None

Población: Review of anti-atherosclerotic supplements and bleeding

Other

Extensive Bioactivity of Astaxanthin from Haematococcus pluvialis in Human.

Dose: None vs: None Outcome: None Efecto: None None

Población: None

Other

Supplementation with Resveratrol, Piperine and Alpha-Tocopherol Decreases Chronic Inflammation in a Cluster of Older Adults …

Dose: None vs: Conventional treatment Outcome: effect of a dietary supplement on chronic inflammation … Efecto: None p < 0.05

Población: None

Review

Nutrient intake, nutritional status, and cognitive function with aging.

Dose: None vs: None Outcome: None Efecto: None None

Población: Aging adults (nutrition and cognition)

Review

Role of reactive oxygen species and antioxidants in atopic dermatitis.

Dose: None vs: None Outcome: Role of oxidative stress in atopic dermatitis Efecto: None None

Población: Patients with atopic dermatitis

Review

Astaxanthin: a novel potential treatment for oxidative stress and inflammation in cardiovascular disease.

Dose: None vs: None Outcome: Astaxanthin: a novel potential treatment for oxidative stress … Efecto: None None

Población: None

Key Statistics

Estudios

50000

Participantes

↔

Mixed

Calificación

Referenced Papers

Navigating the Effects of Anti-Atherosclerotic Supplements and Acknowledging Associated Bleeding Risks. Review

International journal of … 2025 1 citas

Extensive Bioactivity of Astaxanthin from Haematococcus pluvialis in Human. Other

Advances in experimental … 2021 13 citas

Supplementation with Resveratrol, Piperine and Alpha-Tocopherol Decreases Chronic Inflammation in a Cluster of Older Adults with Metabolic Syndrome. Other

Nutrients 2020 16 citas

Nutrient intake, nutritional status, and cognitive function with aging. Review

Annals of the … 2016 89 citas

Role of reactive oxygen species and antioxidants in atopic dermatitis. Other

Journal of clinical … 2013 178 citas

Astaxanthin: a novel potential treatment for oxidative stress and inflammation in cardiovascular disease. Review

The American journal … 2008 441 citas

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosificaciones de uso común

note:: High-dose supplementation no longer recommended based on clinical trial evidence
general:: 15 mg/day (22.4 IU)

Límite superior: 1,000 mg/day (1,500 IU natural, 1,100 IU synthetic)

Dosificaciones estudiadas en la investigación

Dosificación	Duración	Efecto	N
None	--	Mixed	--
None	--	Positive	--
None	--	Mixed	--
None	--	Mixed	--
None	--	Positive	--
None	--	Positive	--

Mejor momento para tomar: With meals containing fat

Safety & Side Effects

Efectos secundarios reportados

⚠ Increased bleeding risk at high doses
⚠ Possible increased all-cause mortality at >=400 IU/day
⚠ Increased heart failure hospitalization risk (HOPE/HOPE-TOO)
⚠ Nausea, diarrhea, fatigue at high doses

Interacciones conocidas

● Anticoagulants (increased bleeding risk)
● Statins and niacin (may blunt HDL-raising effect)
● Chemotherapy and radiation (theoretical interference with oxidative mechanisms)
● Vitamin K (may antagonize at high doses)

Ingesta máxima tolerable: 1,000 mg/day (1,500 IU natural, 1,100 IU synthetic)

Consulte siempre a su profesional de salud antes de comenzar cualquier suplemento.Siempre consulte a su profesional de salud antes de comenzar cualquier suplemento.

Frequently Asked Questions

Does Vitamin E help with Atherosclerosis?

Based on 15 studies with 50,000 participants, there is limited but promising evidence that Vitamin E may support Atherosclerosis management. Our evidence grade is C (Some Evidence).

How much Vitamin E should I take for Atherosclerosis?

Studies have used various dosages. A commonly studied range is High-dose supplementation no longer recommended based on clinical trial evidence. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Vitamin E?

Reported side effects may include Increased bleeding risk at high doses, Possible increased all-cause mortality at >=400 IU/day, Increased heart failure hospitalization risk (HOPE/HOPE-TOO), Nausea, diarrhea, fatigue at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Vitamin E and Atherosclerosis?

We rate the evidence as Grade C (Some Evidence). This rating is based on 15 peer-reviewed studies with 50,000 total participants. The overall direction of effect is mixed.

Otros ingredientes para Atherosclerosis

Nattokinase B Resveratrol C Lycopene D Quercetin D Flaxseed Oil D Olive Leaf Extract D

Veredicto rápido

Evidence Strength52%

Moderate confidence

Desglose de estudios

RCT (0)Meta (0)Other (15)

Comparar alternativas

Vea cómo se comparan otros ingredientes para esta condición.

Ver todos los ingredientes para Atherosclerosis

Más información

References

[1] Maria-Zinaida Dobre et al.. Int J Mol Sci. 2025. Navigating the Effects of Anti-Atherosclerotic Supplements and Acknowledging Associated Bleeding Risks. doi:10.3390/ijms262010183 PubMed
[2] Eiji Yamashita. Adv Exp Med Biol. 2021. Extensive Bioactivity of Astaxanthin from Haematococcus pluvialis in Human. doi:10.1007/978-981-15-7360-6_23 PubMed
[3] Raúl Francisco Pastor et al.. Nutrients. 2020. Supplementation with Resveratrol, Piperine and Alpha-Tocopherol Decreases Chronic Inflammation in a Cluster of Older Adults with Metabolic Syndrome. doi:10.3390/nu12103149 PubMed
[4] Katherine L Tucker. Ann N Y Acad Sci. 2016. Nutrient intake, nutritional status, and cognitive function with aging. doi:10.1111/nyas.13062 PubMed
[5] N Sivaranjani et al.. J Clin Diagn Res. 2013. Role of reactive oxygen species and antioxidants in atopic dermatitis. doi:10.7860/JCDR/2013/6635.3732 PubMed
[6] Fredric J Pashkow et al.. Am J Cardiol. 2008. Astaxanthin: a novel potential treatment for oxidative stress and inflammation in cardiovascular disease. doi:10.1016/j.amjcard.2008.02.010 PubMed

Aviso legal FDA: Estas declaraciones no han sido evaluadas por la Food and Drug Administration. Los productos y la información en este sitio web no están destinados a diagnosticar, tratar, curar ni prevenir ninguna enfermedad. Las calificaciones de evidencia presentadas se basan en nuestro análisis de investigación publicada revisada por pares y no constituyen consejo médico. Siempre consulte a su profesional de salud antes de comenzar cualquier régimen de suplementos.

Vitamin E para Atherosclerosis

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Conclusión

Key Study Findings

Key Statistics

Referenced Papers

Dosage & Usage

Dosificaciones de uso común

Dosificaciones estudiadas en la investigación

Safety & Side Effects

Efectos secundarios reportados

Interacciones conocidas

Frequently Asked Questions

Related Evidence

Otros ingredientes para Atherosclerosis

References